Effect of butorphanol administration on cardiovascular parameters in isoflurane-anesthetized horses – a retrospective clinical evaluation

Hofmeister, Erik H.; Mackey, Elizabeth B.; Trim, Cynthia M.

doi:10.1111/j.1467-2995.2007.00355.x

Cited by 20 publications

(12 citation statements)

References 23 publications

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“…This result is consistent with results of previous studies indicating that butorphanol does not significantly alter cardiorespiratory function in horses after administration intramuscular, intravenuous or at continuous rate infusion 7,8,13,14 .…”

Section: Discussionsupporting

confidence: 83%

Effects of a continuous rate infusion of butorphanol in isoflurane-anesthetized horses on cardiorespiratory parameters, recovery quality, gastrointestinal motility and serum cortisol concentrations

et al. 2014

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Conception, design, intellectual and scientific content of the study; statistical analysis. ABSTRACT PURPOSE:To assess the cardiorespiratory parametes, recovery, gastrointestinal motility and serum cortisol concentrations in horses anesthetized with isoflurane with or without a continuous rate infusion (CRI) of butorphanol for orchiectomy. METHODS:Twelve adult, intact, male horses weighing 332 ± 55 kg were included in the study. Xilazine was administered as premedication. Anesthesia was induced with ketamine and midazolam and maintained with isoflurane. Butorphanol (0.025 mg kg -1 bolus) or an equivalent volume of saline (0.9%) was given intravenously followed by a CRI of butorphanol (BG) (13 µg kg -1 hour -1 ) or saline (CG). Cardiorespiratory variables were recorded before (T0) and every 15 minutes for 75 minutes after the start of infusion.Serum cortisol concentration was measured at T0 and 60 minutes, and 30 minutes and 19 hours after the horse stood up. Recovery from anesthesia was evaluated using a scoring system. Gastrointestinal motility was evaluated before anesthesia and during 24 hours after recovery. RESULTS:There were no significant differences between groups in cardiopulmonary variables, or recovery scores or serum cortisol concentrations. A reduction in gastrointestinal motility was recorded for 60 minutes in BG. CONCLUSIONS:Continuous rate infusion of butorphanol in horses anesthetized with isoflurane did not adversely affect the cardiopulmonary variables monitored, or recovery scores. A small but statistically significant reduction in gastrointestinal motility occurred in the butorphanol group.

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Section: Discussionsupporting

confidence: 83%

Effects of a continuous rate infusion of butorphanol in isoflurane-anesthetized horses on cardiorespiratory parameters, recovery quality, gastrointestinal motility and serum cortisol concentrations

et al. 2014

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“…Additionally, following these high doses of fentanyl, very poor quality recoveries were observed in some horses. Clinical studies that have investigated the use of opioids during inhalation anaesthesia are either of retrospective nature (Hofmeister et al. 2008) or were performed in a very small number of horses (Clark et al.…”

Section: Discussionmentioning

confidence: 99%

“…2003). In contrast, the use of butorphanol in clinical cases resulted in a reduced sympathetic response to noxious stimuli and was therefore considered a beneficial combination with inhalation anaesthesia (Hofmeister et al. 2008).…”

Section: Introductionmentioning

confidence: 99%

A clinical study on the effect in horses during medetomidine–isoflurane anaesthesia, of butorphanol constant rate infusion on isoflurane requirements, on cardiopulmonary function and on recovery characteristics

Bettschart‐Wolfensberger

Dicht

Vullo

et al. 2011

Veterinary Anaesthesia and Analgesia

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“…Unter Isoflurananästhesie ließ sich bei Pferden (30) und Alpakas (24) nach Butorphanolgabe ein geringgradiger, klinisch irrelevanter Abfall des arteriellen Blutdrucks und des systemischen Gefäßwiderstands feststellen. Bei Katzen in Isoflurananästhesie trat nach intravenöser Injektion einer Kombination aus Midazolam (0,2 mg/kg KM) und Butorphanol (0,4 mg/kg KM) ein geringgradiger Abfall der Herzfrequenz, des Blutdrucks und der Atemfrequenz auf (26).…”

Section: Kardiovaskuläre Wirkungenunclassified

Zur Anwendung von Butorphanol in der Veterinärmedizin

Kästner¹

2008

Tierarztl Prax Ausg K

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Zusammenfassung:Butorphanol wird international seit mehreren Jahrzehnten in der Humanund Veterinärmedizin als Analgetikum, zur sedativ-analgetischen Anästhesieprämedikation und als Antitussivum eingesetzt. Das Ziel der vorliegenden Arbeit ist, anhand einer Literaturübersicht die pharmakologischen Eigenschaften, klinischen Wirkungen und Einsatzgebiete von Butorphanol in der Veterinärmedizin darzustellen. In den Datenbanken Pubmed und CAB International erfolgte eine Literaturrecherche mit dem Suchbegriff „butorphanol*“. Insgesamt wurden 84 Literaturstellen in die Übersicht einbezogen. Butorphanol ist ein vollsynthetischer Morphinabkömmling. In Deutschland unterliegt der Wirkstoff derzeit nicht den betäubungsmittelrechtlichen Bestimmungen. Seine Hauptwirkungen entfaltet Butorphanol als Agonist an den κ-Opiatrezeptoren. Butorphanol vermittelt bei Pferd, Hund und Katze eine effektive viszerale Analgesie mit einer dosisabhängigen kurzen bis mittleren Wirkungsdauer. Im Bereich der somatischen Analgesie zeigte es bei diesen Spezies eine geringe Effektivität. Als Hauptindikationen für die Anwendung von Butorphanol bei Pferd und Kleintier müssen Sedation, Anästhesie Prämedikation und perioperative Analgesie im Zusammenhang mit abdominalen chirurgischen Eingriffen sowie die Therapie des Kolikschmerzes beim Pferd betrachtet werden.

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Effect of butorphanol administration on cardiovascular parameters in isoflurane-anesthetized horses – a retrospective clinical evaluation

Cited by 20 publications

References 23 publications

Effects of a continuous rate infusion of butorphanol in isoflurane-anesthetized horses on cardiorespiratory parameters, recovery quality, gastrointestinal motility and serum cortisol concentrations

Effects of a continuous rate infusion of butorphanol in isoflurane-anesthetized horses on cardiorespiratory parameters, recovery quality, gastrointestinal motility and serum cortisol concentrations

A clinical study on the effect in horses during medetomidine–isoflurane anaesthesia, of butorphanol constant rate infusion on isoflurane requirements, on cardiopulmonary function and on recovery characteristics

Zur Anwendung von Butorphanol in der Veterinärmedizin

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