Effect of C. parvum and active specific immunotherapy on intracerebral transplants of a murine fibrosarcoma

Woodruff, M. F. A.; Hitchcock, Edward; Whitehead, Valerie L.

doi:10.1038/bjc.1977.105

Cited by 6 publications

(1 citation statement)

References 5 publications

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“…Studies of the effect of C. parvum on the growth of implanted brain tumor in mice have been reported by Woodruff et al [32]. In agreement with our results, they reported significant prolongation of survival in mice that had been given an intracerebral inoculation of tumor followed by direct injection of C. parvum into the tumor site 1 -7 days later.…”

Section: Discussionsupporting

confidence: 93%

Effect of intracerebrally injected Corynebacterium parvum on implanted brain tumor in mice

Kennedyl

Conley

1989

J Neuro-Oncol

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Experiments were performed to determine the effectiveness of Corynebacterium parvum on resistance to growth and development of tumor in the central nervous system. A syngeneic sarcoma was injected intracerebrally into C3H/HeN/MTV-negative female mice that had received intraperitoneal injections of C. parvum or saline prior to tumor inoculation or that received intraperitoneal C. parvum or saline after tumor inoculation. Groups then received an intracerebral injection of C. parvum or saline. Our results reveal that intracerebral C. parvum elicited an intracerebral inflammatory reaction which was enhanced by prior systemic priming with C. parvum. Any inflammatory reaction which was enhanced by prior systemic priming with C. parvum. Any inflammatory reaction produced by C. parvum retarded the growth of intracerebrally-implanted sarcoma and significantly increased the survival of mice bearing such tumors. These results suggest that C. parvum may be an effective therapeutic agent in the treatment of neoplasia of the central nervous system.

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Section: Discussionsupporting

confidence: 93%

Effect of intracerebrally injected Corynebacterium parvum on implanted brain tumor in mice

Kennedyl

Conley

1989

J Neuro-Oncol

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C. Parvum immunotherapy of transplanted rat tumours

Pimm

Baldwin

1977

Intl Journal of Cancer

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C.parvum (Wellcome CN 6134) has been tested for tumour suppression against a range of syngeneically transplanted rat tumours, both carcinogen-induced and of spontaneous origin. Subcutaneous growth was not prevented by distant subcutaneous or intravenous injection of the preparation, although growth rates were sometimes depressed or accelerated. In contrast, C. parvum injected in admixture with tumour cells consistently suppressed their growth and with highly immunogenic tumours induced systemic tumour immunity, C. parvum injected intravenously retarded development of pulmonary tumour deposits, and intrapleural injection suppressed growth of pleural tumours and malignant effusions. Host immunosuppression failed to abrogate the tumour-suppressive effect of locally applied C. parvum, but host macrophage depletion with silica totally abolished the response. These studies indicate that in the rat, tumour suppression is most consistently achieved by regional application of C. parvum, and that this response is more dependent upon local macrophage stimulation than generation of systemic immune responses.

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Neural Implants and Recovery of Function: Human Work

Hitchcock

1992

Recovery From Brain Damage

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Effect of C. parvum and active specific immunotherapy on intracerebral transplants of a murine fibrosarcoma

Abstract: Images Fig.

Cited by 6 publications

References 5 publications

Effect of intracerebrally injected Corynebacterium parvum on implanted brain tumor in mice

Effect of intracerebrally injected Corynebacterium parvum on implanted brain tumor in mice

C. Parvum immunotherapy of transplanted rat tumours

Neural Implants and Recovery of Function: Human Work

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