Effect of C‐Reactive Protein-to-Albumin Ratio on Prognosis in Gastric Cancer Patients

Alkurt, Ertuğrul Gazi; DURAK>, Doğukan; Turhan, Veysel Barış; Şahiner, İbrahim Tayfun

doi:10.7759/cureus.23972

Cited by 9 publications

(7 citation statements)

References 33 publications

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“…We conducted a literature review on DEmRNAs in the PPI submodules of the three lesion stages (Tables S1–S5, Supporting Information [ 15–42 ] ). All the DEmRNAs were confirmed to be associated with cancers.…”

Section: Resultsmentioning

confidence: 99%

Quantitative Analysis on Molecular Characteristics Evolution of Gastric Cancer Progression and Prognosis

Wei

et al. 2023

Advanced Biology

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The dynamic changes of key biological characteristics from gastric low‐grade intraepithelial neoplasia (LGIN) to high‐grade intraepithelial neoplasia (HGIN) to early gastric cancer (EGC) are still unclear, which greatly affect the accurate diagnosis and treatment of EGC and prognosis evaluation of gastric cancer (GC). In this study, bioinformatics methods/tools are applied to quantitatively analyze molecular characteristics evolution of GC progression, and a prognosis model is constructed. This study finds that some dysregulated differentially expressed mRNAs (DEmRNAs) in the LGIN stage may continue to promote the occurrence and development of EGC. Among the LGIN, HGIN, and EGC stages, there are differences and relevance in the transcription expression patterns of DEmRNAs, and the activation related to immune cells is very different. The biological functions continuously changed during the progression from LGIN to HGIN to EGC. The COX model constructed based on the three EGC‐related DEmRNAs has GC prognostic risk prediction ability. The evolution of biological characteristics during the development of EGC mined by the authors provides new insight into understanding the molecular mechanism of EGC occurrence and development. The three‐gene prognostic risk model provides a new method for assisting GC clinical treatment decisions.

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Section: Resultsmentioning

confidence: 99%

Quantitative Analysis on Molecular Characteristics Evolution of Gastric Cancer Progression and Prognosis

Wei

et al. 2023

Advanced Biology

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“…Blood samples were taken from all patients before surgery, and complete blood counts and biochemical parameters were measured. The calculation of the inflammatory indices is as follows: neutrophil to lymphocyte ratio (NLR) = neutrophil count/ lymphocyte count, platelet to lymphocyte ratio (PLR) = platelet count/lymphocyte count, SII = platelet count × neutrophil count/lymphocyte count, C-reactive protein (CRP) to albumin ratio (CAR) = CRP / albumin levels (Qiu, Zhang, and Chen, 2021;Uzunoglu and Kaya, 2023;Alkurt, 2022).…”

Section: Laboratory Parametersmentioning

confidence: 99%

“…Meanwhile, lymphocytes are instrumental in moderating tumor progression by producing cytokines and facilitating robust cellular immune responses (Ogiya, 2016). In this regard, many studies have shown that inflammatory indices such as NLR, PLR, and CAR can be used as prognostic biomarkers in patients with gastric cancer (Liang et al, 2020;Fu et al, 2021;Nechita, 2023;Alkurt et al, 2022). Previous studies have shown that CAR is a better prognostic indicator than mGPS (Lee, 2020;Liu, 2015).…”

Section: Figure 1 Diagnostic Performance Of Inflammatory Indices In P...mentioning

confidence: 99%

Mide Kanseri Hastalarında İnflamatuar Parametrelerin Subtotal ve Total Gastrektomi Sonrası Sağkalımla İlişkisi

UÇAR,

TAŞ,

ARSLAN

et al. 2023

Fabad J Pharm Sci

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This study aimed to assess the differences in inflammatory markers and modified Glasgow prognostic score (mGPS) among patients diagnosed with gastric cancer who underwent subtotal or total gastrectomy, and to evaluate the diagnostic performance of these markers in predicting prognosis. The study included 103 patients diagnosed with gastric cancer who had undergone subtotal (n:48) or total gastrectomy (n:55). The inflammatory indices were respectively calculated as follows: neutrophil to lymphocyte ratio (NLR) = neutrophil count / lymphocyte count, platelet to lymphocyte ratio (PLR) = platelet count / lymphocyte count, SII = platelet count × neutrophil count / lymphocyte count, C-reactive protein (CRP) to albumin ratio (CAR) = CRP / albumin levels. The mGPS was determined using established criteria based on CRP and ALB levels. The endpoint was the 3-year survival outcomes for all patients. The mean age of the patients included in the study was 65.9±9.7 years, and the vast majority were male (68.9%). The inflammatory indices did not demonstrate significant differences between the subtotal and total gastrectomy groups. Multiple Cox regression analysis showed that elevated SII (HR = 1.12, p < 0.001) were independent predictors of the 3-year mortality. In predicting the 3-year mortality, SII demonstrated superior diagnostic performance compared to other inflammatory indices (Area under the curve: 0.843, Sensitivity: 90.5% and Specificity = 67.1%). In patients with gastric cancer who have undergone subtotal and total gastrectomy, SII could serve as an important screening tool for predicting long-term prognosis, regardless of the surgical procedure.

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“…Accumulating evidence suggests that immune responses and inflammation influence tumor progression and metastasis ( 7 ). Many inflammatory blood-based indices, such as the neutrophil-to-lymphocyte ratio (NLR) ( 8 ), platelet-to-lymphocyte ratio (PLR), albumin-to-globulin ratio (AGR) ( 9 ), lymphocyte-to-monocyte ratio (LMR) ( 10 ), and C-reactive protein-to-albumin ratio (CAR) ( 11 ), are significant prognostic markers of different cancer types. The systemic inflammation response index (SIRI) is a novel hematologic parameter that was first proposed in 2016 ( 12 ) and is determined using the following formula: SIRI = (neutrophil × monocyte)/lymphocyte count.…”

Section: Introductionmentioning

confidence: 99%

Prognostic and clinicopathological significance of systemic inflammation response index in patients with hepatocellular carcinoma: a systematic review and meta-analysis

Zhang,

Tang

2024

Front. Immunol.

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BackgroundIt is unclear whether the systemic inflammation response index (SIRI) can predict the prognosis of patients with hepatocellular carcinoma (HCC). Consequently, the present study focused on systematically identifying the relationship between SIRI and the prognosis of patients with HCC through a meta-analysis.MethodsSystematic and comprehensive studies were retrieved from PubMed, Web of Science, Embase, and the Cochrane Library from their inception to August 10, 2023. The role of SIRI in predicting overall survival (OS) and progression-free survival (PFS) in HCC was determined using pooled hazard ratios (HRs) and 95% confidence intervals (CIs). Odds ratios (ORs) and 95% CIs were pooled to analyze the correlations between SIRI and the clinicopathological features of HCC.ResultsTen articles involving 2,439 patients were included. An elevated SIRI was significantly associated with dismal OS (HR=1.75, 95% CI=1.52–2.01, p<0.001) and inferior PFS (HR=1.66, 95% CI=1.34–2.05, p<0.001) in patients with HCC. Additionally, according to the combined results, the increased SIRI was significantly related to multiple tumor numbers (OR=1.42, 95% CI=1.09–1.85, p=0.009) and maximum tumor diameter >5 cm (OR=3.06, 95% CI=1.76–5.30, p<0.001). However, the SIRI did not show any significant relationship with sex, alpha-fetoprotein content, Child-Pugh class, or hepatitis B virus infection.ConclusionAccording to our results, elevated SIRI significantly predicted OS and PFS in patients with HCC. Moreover, the SIRI was significantly associated with tumor aggressiveness.Systematic review registrationhttps://inplasy.com/inplasy-2023-9-0003/, identifier INPLASY202390003.

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Effect of C‐Reactive Protein-to-Albumin Ratio on Prognosis in Gastric Cancer Patients

Cited by 9 publications

References 33 publications

Quantitative Analysis on Molecular Characteristics Evolution of Gastric Cancer Progression and Prognosis

Quantitative Analysis on Molecular Characteristics Evolution of Gastric Cancer Progression and Prognosis

Mide Kanseri Hastalarında İnflamatuar Parametrelerin Subtotal ve Total Gastrektomi Sonrası Sağkalımla İlişkisi

Prognostic and clinicopathological significance of systemic inflammation response index in patients with hepatocellular carcinoma: a systematic review and meta-analysis

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