1999
DOI: 10.1159/000014164
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Effect of C1-Inhibitor in a Rat Model of Necrotizing Enterocolitis

Abstract: Our aim was to investigate the effect of C1-inhibitor (C1-INH) in a rat model of necrotizing enterocolitis (NEC). Twenty-four anesthetized and artificially ventilated rats received 0.1 mg/kg endotoxin. Fifteen minutes later, the animals in the study group (n = 12) were treated with 200 IU/kg C1-INH whereas the control animals (n = 12) received normal saline. In all animals, FiO2 was reduced after 90 min from 0.21 to 0.05 and ventilation continued until 180 min or death. All animals developed shock s… Show more

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