Effect of Cabergoline in Experimental Endometriosis in Rats

Silva, Júlio César Rosa e; Fortunato, GG; Zanardi, José Vitor Cabral; Meola, Juliana; Nogueira, AA

doi:10.1016/j.jmig.2015.08.627

Cited by 1 publication

(1 citation statement)

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“…(65) The disease is associated with dysmenorrhea, deep dyspareunia, chronic pelvic pain and infertility (66,67) and is considered a public health concern, given the impact on patient physical and psychological health, and the socioeconomic impact of diagnosis, treatment and clinical control costs. (68) The final diagnosis of endometriosis is currently based on histological analysis of the lesion, usually in samples obtained by laparoscopic surgery. (69) However, imaging modalities are important non-invasive diagnostic alternatives for ovarian and deep endometriosis.…”

Section: ❚ Discussionmentioning

confidence: 99%

Overview of miRNAs for the non-invasive diagnosis of endometriosis: evidence, challenges and strategies. A systematic review

Monnaka¹,

Hernandes²,

Heller³

et al. 2021

Einstein (São Paulo)

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Objective The aim of the study was to assess the evidence on miRNAs as biomarkers for the diagnosis of endometriosis, as well as to provide insights into the challenges and strategies associated with the use of these molecules as accessible tools in clinical practice. Methods Systematic review conducted on PubMed ® , Latin American and Caribbean Health Sciences Literature (LILACS), MEDLINE ® and Web of Science databases using the search terms endometriosis (all fields) AND miRNA (all fields), evaluating all publication up to May 2019. Results Most miRNAs found to be dysregulated in this study were harvested from tissue samples, which precludes their use as a non-invasive diagnostic test. However, differential expression of 62 miRNAs was reported in samples that may be used for non-invasive diagnosis of endometriosis, such as blood, serum and plasma. Conclusion Despite the identification of several candidates, studies are investigatory in nature and have been conducted with small number of samples. Also, no particular miRNA has been validated for diagnostic purposes so far. Studies based primarily on biological samples and applicable to translational research are warranted. Large databases comprising information on sample type and the use of saliva and vaginal fluid for miRNAs identification may prove essential to overcome current barriers to diagnosis of endometriosis.

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Section: ❚ Discussionmentioning

confidence: 99%