Effect of Cadmium Chloride on the Distal Retinal Pigment Cells of the Fiddler Crab, Uca pugilator

Ps, Reddy; Lk, Nguyen; Obih, Patience; Fingerman, Milton

doi:10.1007/s001289900363

Cited by 10 publications

(5 citation statements)

References 12 publications

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“…The secretion of hormones that regulate the migration of both eye pigment and melanin into chromatophores is modulated by neurotransmitters and neuromodulators, and pollutants, such as cadmium and naphthalene, are capable of modifying the secretion of these hormones [26]. In adult specimens of Uca pugilator , exposure to cadmium causes a reduction in the distal retinal pigment migration toward the light‐adaptation position [27] and has an inhibiting effect on the pigment‐dispersing hormone in the chromatophores [28].…”

Section: Discussionmentioning

confidence: 99%

Differential toxicity of copper, zinc, and lead during the embryonic development of Chasmagnathus granulatus (Brachyura, varunidae)

Lavolpe

Greco

Kesselman

et al. 2004

Enviro Toxic and Chemistry

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Ovigerous females of the estuarine crab Chasmagnathus granulatus were exposed to copper (0.01 and 1 mg/L), zinc (0.05, 1, and 10 mg/L), or lead (0.01 and 1 mg/L) during early, late, or whole embryonic development. None of the assayed heavy metals produced a significant mortality of females, neither a decrease in the number of hatched larvae nor a decrease in the egg incubation time, but several morphological abnormalities were detected in hatched larvae. The abnormalities were classified in three categories: eye, body pigmentary, and body morphological abnormalities. Those larvae with eye and body pigmentary abnormalities, particularly those involving retinal pigments and chromatophores, showed the highest incidence by exposure to the assayed metals. In addition, embryos were more susceptible to copper and zinc during the late period of development, whereas the effect of lead was greater during the early period of embryogenesis. Some teratogenic effects observed in C. granulatus embryos exposed to heavy metals, particularly the hypertrophy and hypopigmentation of eyes observed in the laboratory at a lead concentration as low as that reported for the natural environment, could be considered as sensitive biomarkers for this kind of pollutant.

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Section: Discussionmentioning

confidence: 99%

Differential toxicity of copper, zinc, and lead during the embryonic development of Chasmagnathus granulatus (Brachyura, varunidae)

Lavolpe

Greco

Kesselman

et al. 2004

Enviro Toxic and Chemistry

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“…In Danio, the photoreceptors and the inner nuclear layer cells are extensively damaged by cadmium exposure, eliminated via apoptosis and substituted by newly differentiated glial Muller cells [11]. RBBP6-driven cells replacement would contribute to the restoration of the retinal integrity, avoiding more significant structural alterations comparable to those occurring, for example, in lizard embryos, where extensive folding is reported [32] or in invertebrates, such as the crustacean nauplii [33,34]. The same apparently does not occur in ganglion cells in which cytoplasm vacuolization and nuclear pycnosis have also been reported [11], but the expression of RBBP6 is not activated.…”

Section: Discussionmentioning

confidence: 99%

Retinoblastoma binding protein 6 and crystallin lambda 1 are cadmium-responsive genes in zebrafish embryos and adults retinae

Scudiero

Esposito

Simoniello

et al. 2017

Comptes Rendus. Biologies

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Nonessential metal cadmium is widely used and released in the environment, causing cell toxicity and posing a severe threat to wildlife. Zebrafish (Danio rerio) is one of the most commonly used animals in the investigation of environmental cadmium toxicity in vertebrates. In this study, we identified two cadmium-responsive genes, RBBP6 and CRYL1, in the early phases of zebrafish development, at the gastrula stage. The retinoblastoma binding protein 6 is associated with increased protein degradation and cell proliferation; crystallin-lambda 1 is a lens protein with redox activity. In situ hybridization analysis performed on adult zebrafish exposed to 1.5-40 μM cadmium for 30 days confirmed the ability of cadmium to up-regulate the expression of both genes in retinal cells in a dose-dependent manner. The over-expression was transient, being switched off when cadmium was removed. The involvement of RBBP6 and CRYL1 in the onset of cadmium-induced morphological alterations in adult zebrafish retina is discussed.

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“…There are a number of possible explanations for this shift. In this study we focused on the migration of screening pigments that has been shown to occur in L. pugilator (Fielder et al, 1971;Fingerman, 1970;Reddy et al, 1997) and differential regulation of opsin gene expression (DeLeo and Bracken-Grissom, 2020;Katti et al, 2010). Although there is no evidence that the latter occurs in fiddler crabs, there is evidence to suggest that the rhabdom width of the fiddler crab A. tangeri does fluctuate diurnally (Brodrick et al, 2020).…”

Section: Diurnal Shifts In Spectral Sensitivitymentioning

confidence: 99%

“…If waveguide modes vary as a result, it is possible that the contribution of surrounding screening pigments to spectral rhabdomeric absorption could affect the cells' overall spectral sensitivity, with smaller diameter cells predicted to be more affected than larger ones (Van Hateren, 1984). As a further complication, the location of screening pigments within the ommatidia also changes diurnally in the fiddler crab L. pugilator (Fielder et al, 1971;Fingerman, 1970;Reddy et al, 1997). Thus, diel shifts in fiddler crab spectral sensitivities may also be anticipated.…”

Section: Introductionmentioning

confidence: 99%

Photoreceptors and diurnal variation in spectral sensitivity in the fiddler crab Gelasimus dampieri

Jessop

Ogawa

Bagheri

et al. 2020

Journal of Experimental Biology

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Colour signals, and the ability to detect them, are important for many animals and can be vital to their survival and fitness. Fiddler crabs use colour information to detect and recognise conspecifics, but their colour vision capabilities remain unclear. Many studies have attempted to measure their spectral sensitivity and identify contributing retinular cells, but the existing evidence is inconclusive. We used electroretinogram (ERG) measurements and intracellular recordings from retinular cells to estimate the spectral sensitivity of Gelasimus dampieri and to track diurnal changes in spectral sensitivity. G. dampieri has a broad spectral sensitivity and is most sensitive to wavelengths between 420 to 460 nm. Selective adaptation experiments uncovered an ultraviolet (UV) retinular cell with a peak sensitivity shorter than 360 nm. The species’ spectral sensitivity above 400 nm is too broad to be fitted by a single visual pigment and using optical modelling we provide evidence that at least two medium-wavelength sensitive (MWS) visual pigments are contained within a second blue-green sensitive retinular cell. We also found an approximate 25 nm diurnal shift in spectral sensitivity towards longer wavelengths in the evening in both ERG and intracellular recordings. Whether the shift is caused by screening pigment migration or changes in opsin expression remains unclear, but the observation shows the diel dynamism of colour vision in this species. Together, these findings support the notion that G. dampieri possesses the minimum requirement for colour vision, with UV and blue/green receptors, and help to explain some of the inconsistent results of previous research.

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Effect of Cadmium Chloride on the Distal Retinal Pigment Cells of the Fiddler Crab, Uca pugilator

Cited by 10 publications

References 12 publications

Differential toxicity of copper, zinc, and lead during the embryonic development of Chasmagnathus granulatus (Brachyura, varunidae)

Differential toxicity of copper, zinc, and lead during the embryonic development of Chasmagnathus granulatus (Brachyura, varunidae)

Retinoblastoma binding protein 6 and crystallin lambda 1 are cadmium-responsive genes in zebrafish embryos and adults retinae

Photoreceptors and diurnal variation in spectral sensitivity in the fiddler crab Gelasimus dampieri

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