Effect of cadmium chloride on secretion of 17β-estradiol by the ovarian follicles of common carp, Cyprinus carpio

Associations of urinary cadmium with circulating sex hormone levels in pre- and postmenopausal Japanese women

“…might affect aromatase activity, which is responsible for the conversion of testosterone to estradiol in postmenopausal women. In fact, the inhibition of LH-induced aromatase activity by 2 μmol cadmium chloride treatment in carp ovarian follicles was reported (Das and Mukherjee, 2013). Our results differed between pre-and postmenopausal women.…”

“…Previous animal studies have reported that a high dose of cadmium (4 ¼50 μg) decreased estradiol or testosterone levels (Piasek and Laskey, 1999;Paksy et al, 1990), suggesting a suppression of steroidogenesis. In recent years, some laboratory studies also examined the lower dose of cadmium and observed a decrease in estradiol or testosterone even at low concentrations (Das and Mukherjee, 2013;Knazicka et al, 2015). Like observed in these laboratory studies, cadmium exposure may affect the synthesis of estrogen and androgen in premenopausal women.…”

Associations between cadmium exposure and circulating levels of sex hormones in postmenopausal women

“…A recent study reported that Cd exposure is effective in inhibiting the 17β-estradiol synthesis by ovarian follicles of the common carp, Cyprinus carpio at vitellogenic stage in vivo. Furthermore Cd also inhibits lutenizing hormone (LH)-induced ovarian aromatase activity (conversion of testosterone to 17β-estradiol) and P450 arom gene expression in vitro (Das and Mukherjee, 2013). To indirectly elucidate this aspect of LH-induced aromatase activity in our study population, we modeled the estradiol/ testosterone ratio towards B-Cd.…”

GnIH plays a negative role in regulating GtH expression in the common carp, Cyprinus carpio L.

“…It is also a kind of model to study the regulation of reproduction (Cao et al, 2014;Das and Mukherjee, 2013;Hu et al, 2007;Majumder et al, 2015;Tang et al, 2010;Xu et al, 2011). Sequencing and assembly of the whole genome have been completed recently (Xu et al, 2014).…”