Effect of cadmium, copper and mercury on antioxidant enzyme activities and lipid peroxidation in the gills of the hydrothermal vent mussel Bathymodiolus azoricus

Serafim, A.; Bebianno, Maria João; Cosson, Richard P.; Shillito, Bruce; Fiala-Médioni, Aline

doi:10.1016/j.marenvres.2004.03.083

Cited by 183 publications

(101 citation statements)

References 9 publications

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“…Henczová et al (2008) had reported that heavy metals can interact with hepatic microsomal cytochrome P450, and cause complex changes in the cytochrome P450-dependent metabolism in fish. Hereby, the regulation in the CYP414A1 expression could be induced by the production of reactive oxygen species generated by Cd and Cu exposure (Company et al, 2004). Further studies of CYP414A1 transcriptional initiation sites and its antioxidant defense may be a key step towards understanding its transcriptional regulatory mechanism.…”

Section: Modulation Of Cyp414a1 Gene Expression In Hepatopancreas Of mentioning

confidence: 99%

Identification and expression profile of a new cytochrome P450 isoform (CYP414A1) in the hepatopancreas of Venerupis (Ruditapes) philippinarum exposed to benzo[a]pyrene, cadmium and copper

Zhang

Gan

et al. 2012

Environmental Toxicology and Pharmacology

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Section: Modulation Of Cyp414a1 Gene Expression In Hepatopancreas Of mentioning

confidence: 99%

Identification and expression profile of a new cytochrome P450 isoform (CYP414A1) in the hepatopancreas of Venerupis (Ruditapes) philippinarum exposed to benzo[a]pyrene, cadmium and copper

Zhang

Gan

et al. 2012

Environmental Toxicology and Pharmacology

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“…As it is known, Cd can induce multiple adverse effects in organisms. It may induce oxidative stress in organisms by producing excessive reactive oxygen species [3]. Additionally, Cd can disturb the energy metabolism in clam Ruditapes philippinarum indicated by the enhanced anaerobic metabolism [4].…”

Section: Introductionmentioning

confidence: 99%

Proteomic responses reveal the differential effects induced by cadmium in mussels Mytilus galloprovincialis at early life stages

Peng

et al. 2016

Fish & Shellfish Immunology

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a b s t r a c tCadmium (Cd) has become an important metal contaminant and posed severe risk on the organisms in the coastal environments of the Bohai Sea. Marine mussel Mytilus galloprovincialis is widely distributed along the Bohai coast and consumed as seafood by local residents. Evidences indicate that the early stages of marine organisms are more sensitive to metal contaminants. In this study, we applied twodimensional electrophoresis-based proteomics to characterize the biological effects of Cd (50 mg L À1 ) in the early life stages (D-shape larval and juvenile) of mussels. The different proteomic responses demonstrated the differential responsive mechanisms to Cd exposure in these two early life stages of mussels. In details, results indicated that Cd mainly induced immune and oxidative stresses in both Dshape larval and juvenile mussels via different pathways. In addition, the significant up-regulation of triosephosphate isomerase and metallothionein confirmed the enhanced energy demand and mobilized detoxification mechanism in D-shape larval mussels exposed to Cd. In juvenile mussels, Cd exposure also induced clear apoptosis. Overall, this work suggests that Cd is a potential immune toxicant to mussel M. galloprovincialis at early life stages.

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“…Cd may inactivate many metabolic enzymes by competing for the catalytic sites with other metals [6,7]. In addition, both Cd and As can induce oxidative stress in animals by producing excessive reactive oxygen species [8]. Since Cd and As have become severe metal/metalloid contaminants in the Bohai coast, it is necessary to characterize the biological effects of Cd and As in marine animals.…”

Section: Introductionmentioning

confidence: 99%

Proteomic and metabolomic responses in D-shape larval mussels Mytilus galloprovincialis exposed to cadmium and arsenic

et al. 2016

Fish & Shellfish Immunology

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a b s t r a c tCadmium (Cd) and arsenic (As) are the main metal/metalloid contaminants in the coastal environments of the Bohai Sea, China. In this work, a combined proteomic and metabolomic approach was applied to investigate the biological effects of Cd and As (V) in the early life stage (D-shape larvae) of mussel Mytilus galloprovincialis. Results indicated that Cd was a potential immune toxicant to D-shape larval mussel because of the numerous proteomic responses related to immune system. Additionally, Cd induced oxidative stress, cellular injury and disturbance in nucleic acid metabolism in D-shape larval mussels. However, only two identified proteins were significantly altered in As (V)-treated group, suggesting that D-shape larval mussel was less sensitive to As (V) than to Cd at protein level. These two proteins in response to As (V) suggested that As (V) influenced anti-oxidative system and cell proliferation in Dshape larval mussels. Metabolic responses indicated that Cd and As (V) induced disturbances in osmotic regulation and energy metabolism in D-shape larval mussels via different metabolic pathways. In addition, Cd reduced lipid metabolism as well. This work demonstrated that a combination of proteomics and metabolomics could provide an insightful view in the biological effects of pollutants in mussel M. galloprovincialis at an early life stage.

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Effect of cadmium, copper and mercury on antioxidant enzyme activities and lipid peroxidation in the gills of the hydrothermal vent mussel Bathymodiolus azoricus

Cited by 183 publications

References 9 publications

Identification and expression profile of a new cytochrome P450 isoform (CYP414A1) in the hepatopancreas of Venerupis (Ruditapes) philippinarum exposed to benzo[a]pyrene, cadmium and copper

Identification and expression profile of a new cytochrome P450 isoform (CYP414A1) in the hepatopancreas of Venerupis (Ruditapes) philippinarum exposed to benzo[a]pyrene, cadmium and copper

Proteomic responses reveal the differential effects induced by cadmium in mussels Mytilus galloprovincialis at early life stages

Proteomic and metabolomic responses in D-shape larval mussels Mytilus galloprovincialis exposed to cadmium and arsenic

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