Effect of cafeteria diet on α-MG intestinal absorption in rats

Dameto, M.C; Rayó, J. M.; Esteban, Susana; Prieto, Rafel M.; Tur, Josep A.

doi:10.1016/0300-9629(94)90120-1

Cited by 4 publications

(2 citation statements)

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“…In this study comparing aged mice consuming different amounts of food containing the same caloric density, there are no changes associated with the switch from CR to AL in membrane permeability or in intestinal mass, each of which would result in parallel changes in uptake rates for different nutrients. In contrast, intestinal glucose uptake is correlated with caloric density of food and intestinal mass in young adult rats consuming for several days similar amounts of food containing varying amounts of calories (Planas et al, 1992;Dameto et al, 1994). This suggests that chronic consumption of a lesser amount of food activates different types of adaptive signals and mechanisms from consumption of same amounts of foods which vary in caloric density.…”

Section: Signals For Adaptation To Crmentioning

confidence: 84%

Effects of Changes in Calorie Intake on Intestinal Nutrient Uptake and Transporter mRNA Levels in Aged Mice

Casirola¹,

Lan²,

Ferraris³

1997

The Journals of Gerontology Series A: Biological Sciences and M

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In aged, chronically calorie-restricted (CR) mice, intestinal nutrient uptake is significantly higher than in same-age ad libitum controls. Can this chronic restriction-induced enhancement of uptake be reversed by ad libitum feeding? We addressed this question by switching 32-mo-old chronically CR mice to ad libitum feeding for 4 wk (CRAL). Intestinal transport rate and total intestinal absorptive capacity for D-sugars and several nonessential L-amino acids decreased significantly in CRAL mice. In contrast, switching CR mice to an ad libitum regimen for only 3 d had no effect on intestinal nutrient transport, indicating that the negative effects of ad libitum feeding require a duration longer than the 3-d lifetime of most enterocytes. Permeability of the intestinal mucosa to L-glucose was independent of the switches in diet. Levels of the brushborder glucose transporter SGLTI, brushborder fructose transporter GLUT5, and basolateral sugar transporter GLVT2 mRNA as determined by reverse transcriptase-polymerase chain reaction in 6-, 24-, and 32-mo-old mice were each apparently independent of caloric restriction and age. We conclude that the high rates of intestinal nutrient uptake exhibited by chronically CR mice can be reversed by ad libitum feeding of only 1 mo duration. These decreases in uptake were due mainly to specific decreases in transport per unit weight of intestine and not to nonspecific decreases in intestinal mass. Changes in rates of sugar uptake induced by chronic CR and age are apparently not accompanied by changes in steady-state levels of mRNA coding for those transporters. S TUDIES on calorie restriction (CR) are highly relevant to aging because CR is the only method known to retard aging processes in mammals and to extend both mean and maximum life span in rodents (Masoro et al., 1991). Restriction of macronutrient levels (protein, fat, or carbohydrate) is a much less effective modulator of life span (Turturro et al., 1993). A 24-mo-old (median life span) mouse calorie restricted to 60% of ad libitum since 4 mo of age would have consumed over a span of 20 mo approximately 1.3 kg less food than a same age mouse fed ad libitum (AL); 1.3 kg is 65 times the body weight of a CR C57BL6 mouse. Such a large disparity in amounts of food processed affects intestinal enzyme and transporter levels (Ferraris and Diamond, 1997). Because the small intestine is the only site for nutrient digestion and absorption, studies of gut function during CR may increase our understanding of adaptive mechanisms underlying the ageretarding effects of CR.Only recently did the small intestine receive attention in studies on CR. We have previously shown that, in aged (24 mo old) mice that had been calorie restricted since 4 mo of age, intestinal transport of D-sugars and several amino acids was higher than that in same age AL controls and was comparable to that of young mice fed AL (Ferraris et al., 1993;Casirola et al., 1996). CR of several months duration is probably required before increases in intestinal nutrient transp...

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Section: Signals For Adaptation To Crmentioning

confidence: 84%

Effects of Changes in Calorie Intake on Intestinal Nutrient Uptake and Transporter mRNA Levels in Aged Mice

Casirola¹,

Lan²,

Ferraris³

1997

The Journals of Gerontology Series A: Biological Sciences and M

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“…Este estudo investigou a associação entre a suplementação de fibras solúveis, a dieta de cafeteria e treinamento físico em aorta torácica de ratos Wistar. Este modelo de dieta vem sendo utilizado para induzir o aumento do peso corporal em animais em diferentes épocas de vida (DAMETO et al, 1994). A dieta de cafeteria, independente da utilização de fibras e do exercício físico, mostrou-se decisiva para o ganho de peso dos animais.…”

Section: Figura 3 Fotomicrografia Da Aorta Torácica Dos Grupos Scf (unclassified

Efeitos da Suplementação de Fibras Solúveis, Dieta de Cafeteria e Exercício Físico sobre Aorta Torácica de Ratos

et al. 2016

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RESUMO:As fibras alimentares vêm despertando interesse de especialistas das áreas de nutrição e saúde em geral. Elas contribuem para a redução do risco de desenvolvimento de doenças cardiovasculares, além de ajudar no processo de perda de peso, principalmente quando seu consumo é associado à atividade física. Entretanto, existem poucos estudos associando o uso de fibras solúveis à uma dieta hipercalórica e ao exercício físico. Assim, o objetivo desse estudo foi investigar os efeitos das fibras solúveis sobre a aorta torácica e perfil lipídico de ratos machos wistar sedentários e treinados submetidos à dieta de cafeteria. Os parâmetros morfométrico e estereológico foram: espessura íntima-média e densidade de volume do músculo liso e do colágeno e o perfil lipídico foi, então, determinado. Não foram observadas alterações na espessura da parede vascular, densidade de volume do músculo liso e colágeno. No entanto, o perfil lipídico apresentou-se alterado com o uso da dieta de cafeteria. A fibra alimentar associada ao treinamento aeróbio e a uma dieta balanceada apresentou resultado eficaz, não alterando a morfologia do vaso. PALAVRAS-CHAVE:Aorta; Dieta; Fibras na Dieta; Obesidade. EFFECTS OF SUPPLEMENTATION BY SOLUBLE FIBERS, CAFETERIA DIET AND PHYSICAL EXERCISE ON RATS´ THORACIC AORTAABSTRACT: Food fibers have recently been in the limelight of nutrition and health experts. They reduce the development of cardiovascular diseases and help in the process of loss weight especially when their intake is associated with physical activity. However, few studies are extant on the use of soluble fibers associated to a hypercalorie diet and physical exercise. Current analysis deals with the effects of soluble fibers on the thoracic aorta and lipid profile of sedentary and trained male Wistar rats subjected to a cafeteria diet. Morphometric and stereological parameters comprised mid thickness and density of the volume of the smooth muscle and collagen, and lipid profile. No changes were reported on the thickness of the vascular wall, density of volume of the smooth muscle and collagen. However, lipid profile was modified due to the cafeteria diet. Food fiber associated with aerobic training and with a balanced diet provided an efficacious result with no alteration in the vase´s morphology.

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