Effect of caffeine-chitosan nanoparticles and α-lipoic acid on the cardiovascular changes induced in rat model of obesity

Hosny, Eman N.; Sawie, Hussein G.; Abou-Seif, Howida S.; Khadrawy, Yasser A.

doi:10.1016/j.intimp.2024.111627

Cited by 3 publications

(1 citation statement)

References 76 publications

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“…The same nanosystem was also tested for its ability to mitigate cardiovascular complications induced by obesity in rats. Treatment with α-lipoic acid and caffeine-loaded chitosan nanoparticles alleviated cardiac complications and the cardioprotective effect of the combined treatment, was more evident than that of the two agents used individually [ 160 ]. A nanosphere matrix made of zein (a water-insoluble plant protein derived from maize) and α-lipoic acid was employed to encapsulate Vardenafil, a medication used for the treatment of erectile dysfunction [ 161 ].…”

Section: Exploring the Role Of α-Lipoic Acid In Therapeutic Nanoplatf...mentioning

confidence: 99%

Nanotechnological Approaches to Enhance the Potential of α-Lipoic Acid for Application in the Clinic

Bellini,

Mancin,

Papini

et al. 2024

Antioxidants

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α-lipoic acid is a naturally occurring compound with potent antioxidant properties that helps protect cells and tissues from oxidative stress. Its incorporation into nanoplatforms can affect factors like bioavailability, stability, reactivity, and targeted delivery. Nanoformulations of α-lipoic acid can significantly enhance its solubility and absorption, making it more bioavailable. While α-lipoic acid can be prone to degradation in its free form, encapsulation within nanoparticles ensures its stability over time, and its release in a controlled and sustained manner to the targeted tissues and cells. In addition, α-lipoic acid can be combined with other compounds, such as other antioxidants, drugs, or nanomaterials, to create synergistic effects that enhance their overall therapeutic benefits or hinder their potential cytotoxicity. This review outlines the advantages and drawbacks associated with the use of α-lipoic acid, as well as various nanotechnological approaches employed to enhance its therapeutic effectiveness, whether alone or in combination with other bioactive agents. Furthermore, it describes the engineering of α-lipoic acid to produce poly(α-lipoic acid) nanoparticles, which hold promise as an effective drug delivery system.

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Section: Exploring the Role Of α-Lipoic Acid In Therapeutic Nanoplatf...mentioning

confidence: 99%

Nanotechnological Approaches to Enhance the Potential of α-Lipoic Acid for Application in the Clinic

Bellini,

Mancin,

Papini

et al. 2024

Antioxidants

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Caffeine: A Multifunctional Efficacious Molecule with Diverse Health Implications and Emerging Delivery Systems

Song,

Singh,

Lee

et al. 2024

IJMS

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Natural caffeine is found in many plants, including coffee beans, cacao beans, and tea leaves. Around the world, many beverages, including coffee, tea, energy drinks, and some soft drinks, have this natural caffeine compound. This paper reviewed the results of meta-studies on caffeine’s effects on chronic diseases. Of importance, many meta-studies have shown that regularly drinking caffeine or caffeinated coffee significantly reduces the risk of developing Alzheimer’s disease, epilepsy, and Parkinson’s disease. Based on the health supplements of caffeine, this review summarizes various aspects related to the application of caffeine, including its pharmacokinetics, and various functional health benefits of caffeine, such as its effects on the central nervous system. The importance of caffeine and its use in alleviating or treating cancer, diabetes, eye diseases, autoimmune diseases, and cardiovascular diseases is also discussed. Overall, consuming caffeine daily in drinks containing antioxidant and neuroprotective properties, such as coffee, prevents progressive neurodegenerative diseases, such as Alzheimer’s and Parkinson’s. Furthermore, to effectively deliver caffeine to the body, recently developed nanoformulations using caffeine, for instance, nanoparticles, liposomes, etc., are summarized along with regulatory and safety considerations for caffeine. The U.S. Department of Agriculture (USDA) and the Food and Drug Administration (FDA) recommended that healthy adults consume up to 400 mg of caffeine per day or 5~6 mg/kg body weight. Since a cup of coffee contains, on average, 100 to 150 mg of coffee, 1 to 3 cups of coffee may help prevent chronic diseases. Furthermore, this review summarizes various interesting and important areas of research on caffeine and its applications related to human health.

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Synergistic Effects of Chitosan and Fish Oil on Lipid Metabolism in Rats Fed a High-Fat and Low-Carbohydrate Diet

Liu,

Chang,

Liu

et al. 2024

Nutrients

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Background/Objectives: Although high-fat, low-carbohydrate diets are used for weight loss and type 2 diabetes management, their high-fat content may have negative effects. This study examines the effects of replacing cellulose with chitosan and part of the fat with fish oil in a high-fat, low-carbohydrate diet on lipid metabolism in rats. Methods: The experiment involved 35 six-week-old male SD rats, divided into five groups: normal control diet (ND), high-fat diet (HF), high-fat, low-carbohydrate diet (LC), LC with 5% chitosan (LC-CH), and LC with 5% chitosan and 5% fish oil (LC-CHF). Results: After 15 weeks, the HF group had the highest liver weight, and the LC group had the highest adipose tissue weight. The LC-CHF group showed significantly reduced body, liver, and adipose tissue weights, lower ALT, AST, TNF-α, and cholesterol levels, as well as improved liver enzyme activity and fat synthesis regulation. LC-CHF also promoted fat breakdown in adipose tissue, reducing adipocyte size. Conclusions: Our findings suggest the modified high-fat, low-carbohydrate diet with chitosan and fish oil improved obesity and fatty liver outcomes compared to a standard high-fat diet.

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Effect of caffeine-chitosan nanoparticles and α-lipoic acid on the cardiovascular changes induced in rat model of obesity

Cited by 3 publications

References 76 publications

Nanotechnological Approaches to Enhance the Potential of α-Lipoic Acid for Application in the Clinic

Nanotechnological Approaches to Enhance the Potential of α-Lipoic Acid for Application in the Clinic

Caffeine: A Multifunctional Efficacious Molecule with Diverse Health Implications and Emerging Delivery Systems

Synergistic Effects of Chitosan and Fish Oil on Lipid Metabolism in Rats Fed a High-Fat and Low-Carbohydrate Diet

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