Effect of caffeine contained in a cup of coffee on microvascular function in healthy subjects

Noguchi, Katsuhiko; Matsuzaki, Toshihiro; Sakanashi, Mayuko; Hamadate, Naobumi; Uchida, Taro; Kina-Tanada, Mika; Kubota, Haruaki; Nakasone, Junko; Sakanashi, Matao; Ueda, Shinichiro; Masuzaki, Hiroaki; Ishiuchi, Shogo; Ohya, Yusuke; Tsutsui, Masato

doi:10.1016/j.jphs.2015.01.003

Cited by 55 publications

(40 citation statements)

References 45 publications

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“…Smokers were excluded due to the risk of impaired microvascular function (IJzerman et al, 2003) and potential endothelial dysfunction (Heitzer et al, 2000). All participants were asked to refrain from drinks containing caffeine due to effect on microvascular function in healthy individuals (Noguchi et al, 2015). Subjects with a blood pressure above 140/90 mmHg were excluded as microvascular function has been correlated to blood pressure (Serne et al, 1999).…”

Section: Subjectsmentioning

confidence: 99%

Assessment of microvascular and metabolic responses in the skin

Iredahl¹

2016

Linköping University Medical Dissertations

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The general aim of this project was to develop experimental in vivo models that allow for minimally invasive investigations of responses in the skin to microvascular and metabolic provocations. The cutaneous microvasculature has emerged as a valuable model and been proposed to mirror the microcirculation in other organs. Dysfunction in the cutaneous microcirculation has thus been linked to systemic diseases such as hypertension and diabetes mellitus. Models for investigating skin responses could facilitate the understanding of pathophysiological mechanisms as well as effects of drugs. In the first study, three optical measurement techniques (laser Doppler flowmetry (LDF), laser speckle contrast imaging (LSCI) and tissue viability imaging (TiVi)) were compared against each other and showed differences in their ability to detect microvascular responses to provocations in the skin. TiVi was found more sensitive for measurement of noradrenaline-induced vasoconstriction, while LSCI was more sensitive for measurement of vascular occlusion. In the second study, microvascular responses in the skin to iontophoresis of vasoactive drugs were found to depend on the drug delivery protocol. Perfusion half-life was defined and used to describe the decay in the microvascular response to a drug after iontophoresis. In the third study, the role of nitric oxide (NO) was assessed during iontophoresis of insulin. The results showed a NO-dependent vasodilation in the skin by insulin. In the fourth study the vasoactive and metabolic effects of insulin were studied after both local and endogenous administration. Local delivery of insulin increased skin blood flow, paralleled by increased skin concentrations of interstitial pyruvate and lactate, although no change in glucose concentration was observed. An oral glucose load resulted in an increased insulin concentration in the skin paralleled by an increase in blood flow, as measured using the microdialysis urea clearance technique, although no changes in perfusion was measured by LSCI. The thesis concludes that when studying skin microvascular responses, the choice of measurement technique and the drug delivery protocol has an impact on the measurement results, and should therefore be carefully considered. The thesis also concludes that insulin has metabolic and vasodilatory effects in the skin both when administered locally and as an endogenous response to an oral glucose load. The vasodilatory effect of insulin in the skin is mediated by nitric oxide

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Section: Subjectsmentioning

confidence: 99%

Assessment of microvascular and metabolic responses in the skin

Iredahl¹

2016

Linköping University Medical Dissertations

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“…EDs may contain excessive amounts of caffeine, from 75 to 125 mg per can, and could cause cardiovascular effects, the alteration of endothelial function, the increase of anxiety, heart rate, systolic blood pressure, ventricular tachyarrhythmias and abnormalities of cardiac repolarization time as measured by the QT interval [13][14][15][16][17][18][19][20][21] .…”

Section: Introductionmentioning

confidence: 99%

Survey on Energy Drinks Consumption and Related Lifestyle among Students of Two Italian High Schools

Totaro¹,

Avella²,

Giorgi³

et al. 2018

Preprint

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The European Food Safety Authority (EFSA) has identified some risk factors for the occurrence of side effects linked to energy drinks (EDs) consumption by young people. Tachycardia, sleeplessness, caffeine addiction may be caused by excessive consumption of EDs during parties, sport matches, ect. EDs consumption has been evaluated in a sample of students in Italy together with some aspects of their lifestyle. The survey was performed in two high schools from September 2014 to June 2015. 583 students between 14 to 18 years were recruited and a standard questionnaire (EFSA checklist) was used to collect information on responders characteristics, beverages consumption, EDs with alcohol, and EDs and sports. 350 out of 583 responders (60%) consumed EDs and 146 out of 583 responders (25%) reported an occasional alcohol consumption. Despite 82 out of 146 alcoholic drinkers (56%) were EDs-alcohol consumers, only 70 out of 583 adolescents (12%) reported habitual EDs consumption. Moreover, 38 out of 379 (10%) of all physically active adolescents reported frequent EDs consumption before sportive trainings. Study results highlight the need for primary prevention measures in communication campaigns and training delivered by school to limit potential health threats related to excess of EDs consumption.

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“…Caffeine, the main purine alkaloid, accounting for 2-5% in dried tea (Bermejo et al, 2016), is an important component with bitter taste for quality and function of the tea (Jin et al, 2016). Many reports have shown that proper caffeine ingestion is good for the health of the common people because of its antidiabetic (Fang et al, 2015) and neuroprotective effects (Xu et al, 2016) as well as beneficial cardiovascular actions (Noguchi et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Stop for tea? Enzyme inhibitors from tea – what good are they?

Zhao

et al. 2016

Int J of Food Sci Tech

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Summary Tea possesses many bioactive components including polyphenols, theanine and caffeine. Inhibitory effect of these components on the various enzymes involved in some chronic diseases was reviewed in this study. Many studies revealed that anti‐obesity of tea was mainly ascribed to the polyphenols which could inhibit the activity of the enzymes related to diet metabolism such as α‐amylase, α‐glucosidase and lipase. Inhibitory effect of catechins and caffeine against β‐ and γ‐secretase, acetylcholinesterase, protein kinase C and histone deacetylase might be responsible for the prevention from nervous system diseases. Cytochrome P450 enzymes, cytosolic sulfotransferases, cyclooxygenase‐2 and phosphoinositide‐3‐kinase could be efficiently suppressed by catechins, which would decrease the risk of cancer initiation and proliferation; theanine could lower the activity of some anticarcinogen‐activated enzymes and alleviate the adverse effect of cancer cure. Catechins and caffeine exhibited significant inhibition against the matrix metalloproteinases, histidine decarboxylase and many kinases related to inflammation. Thus, catechins, theanine and caffeine might be employed as inhibitors of the enzymes associated with these chronic diseases.

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Effect of caffeine contained in a cup of coffee on microvascular function in healthy subjects

Cited by 55 publications

References 45 publications

Assessment of microvascular and metabolic responses in the skin

Assessment of microvascular and metabolic responses in the skin

Survey on Energy Drinks Consumption and Related Lifestyle among Students of Two Italian High Schools

Stop for tea? Enzyme inhibitors from tea – what good are they?

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