Effect of Caffeine on Some Selected Biochemical Parameters Using Rat Model

Agomuo, E. N.; Majesty, Duru; Augustine, Benjamin; Amadi, Peter Uchenna; Princess, Ugwokaegbe

doi:10.1155/2017/9303276

Cited by 9 publications

(9 citation statements)

References 37 publications

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“…The signi cant (p<0.05) decrease in RBCs and HGB levels in group III rats when compared with the control suggest possible alterations in the balance between erythropoiesis and erythrocyte destruction as well as inhibition of hemoglobin synthesis [35].…”

Section: Discussionmentioning

confidence: 86%

Biochemical Effects of Matured Stem Extract of Opuntia Dillenii in Male Wistar Rats

Njoku

Augustine

Amadi

et al. 2018

Journal of Biomedical and Clinical Research

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Summary The effect of aqueous matured stem extract of Opuntia dillenii on selected biochemical parameters in Male Wistar rats was explored. Standard analytical methods were applied. Forty Wistar rats (80-100g) were used in the animal studies, separated into four groups. The control group was solely administered normal feed and saline, group I was administered 100mgkg−1 of the extract, group II received 300mgkg−1 of the extract and group III received 500 mg/kg−1 of the extract. A significant increase (p<0.05) in the activities of alanine aminotransferase (ALT) and alkaline phosphatase was observed in group II and III rats, as compared with the controls. A significant decrease in urea and creatinine concentrations was found only in group III rats against the controls. Also, a significant (p<0.05) decrease in triglyceride, total cholesterol, and low density lipoprotein (LDL)-cholesterol was seen in group II and group III rats when compared with the control. The hematological evaluation revealed a significant (p<0.05) decrease in red blood cell and hemoglobin levels in group III rats when compared with the control. The findings showed both beneficial and toxicological effects of the plant. Hence, for optimal therapeutic benefits, a further toxicological survey could still be carried out perhaps at higher doses.

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Section: Discussionmentioning

confidence: 86%

Biochemical Effects of Matured Stem Extract of Opuntia Dillenii in Male Wistar Rats

Njoku

Augustine

Amadi

et al. 2018

Journal of Biomedical and Clinical Research

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“…This is not in line with the earlier observations made by Duru et al [28], on rats given "udu, an antimalarial concoction made from combination of herbal leaves, and Mbongue et al [53] on rats treated with P. guineese for 55days. Zhou et al [54] attributed body weight increase in rats to androgenic property of the substance given to the rats as a result of anabolic activity, while Agomuo et al [36]; and Yehya (2001) noted that loss in weight could be as result of increase in sympathetic tone.…”

Section: Discussionmentioning

confidence: 99%

“…Record has it that man for long has taken advantage of the therapeutic value of medicinal plant constituents on production of drugs that are effective against infectious microorganisms and disease conditions. De Silva [34]; Oladunmoye [35]; and Agomuo et al [36] reported that plant based compounds are in use of many modern medical systems.…”

Section: Introductionmentioning

confidence: 99%

Toxicological evaluation of aqueous leaf extract of Spondias mombin using albino rat

Joel¹,

Stanley

2018

JMHE

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Toxicological evaluation of aqueous leaf extract of Spondias mombin using albino rat was carried out. Twenty-five albino rats were grouped into five groups of five rats each. Group 1 served as the control, while groups 2-5 served as the test groups. The test groups were placed on different doses of the studied leaf extract after the lethal dose was determined. The studied extractconsists mainly of flavonoids, saponins, alkaloid, tannins and cyanogenic glycosides, which have considerable therapeutic values, and reduced body weight considerably in test rats against the control. Levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP)in test rats reduced significantly (p<0.05) when compared to the control. However, the observed histopathological changes associated with the kidney and liver of test rats against those of the control may suggest that the toxicity of the extract could be dose dependent. This study has shown the toxicological evaluation of aqueous leaf extract of S. mombin using albino rat.

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“…Such an exclusion of foods from the regular diet for any reason could affect laboratory test results unless compensated for with pills or fortified food. As a third example, alcohol [7], smoking [8] and high consumption of caffeine [9] can also impact laboratory test results. Although alcohol consumption is prohibited in Saudi Arabia, its effects on different body organs can be assessed by several biochemical and hematological tests [7].…”

Section: Introductionmentioning

confidence: 99%

Knowledge and attitudes of Saudi medical laboratory professionals concerning non-pathological factors influencing test results

Makkawi¹

2021

Iberoam J Med

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Introduction: Successful medical decisions are highly reliant on medical laboratory results; as such, laboratory results are essential to patient health management, and errors in those results may lead to serious complications and death. The aim of the present study was to assess the knowledge of medical laboratory practitioners in Saudi Arabia regarding factors that may influence medical laboratory testing results and the correct actions for troubleshooting. Methods: A total of 256 practitioners participated, representing diverse qualifications and various healthcare sectors. The study utilized a pretested questionnaire comprised of three sections: socio-demographic characteristics, knowledge, and attitudes. Results: The responses demonstrated participants to possess outstanding knowledge of factors that may affect laboratory test results, including biological and pathological factors, diet, and personal habits. Furthermore, participants demonstrated satisfactory attitudes toward such factors. Conclusions: Thus, this study reveals a magnificent image concerning Saudi practitioners’ knowledge and capacity for suitable actions given unexpected test results, and hence their ability to provide correct healthcare services. This constitutes an acceptable overview, particularly as a first pass; nonetheless, more studies on larger cohorts remain required.

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Effect of Caffeine on Some Selected Biochemical Parameters Using Rat Model

Cited by 9 publications

References 37 publications

Biochemical Effects of Matured Stem Extract of Opuntia Dillenii in Male Wistar Rats

Biochemical Effects of Matured Stem Extract of Opuntia Dillenii in Male Wistar Rats

Toxicological evaluation of aqueous leaf extract of Spondias mombin using albino rat

Knowledge and attitudes of Saudi medical laboratory professionals concerning non-pathological factors influencing test results

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