Effect of caffeine on the possible amelioration of diabetic neuropathy: A spectroscopic study

Srivastava, Bhavya; Sen, Souvik; Bhakta, Santanu; Sen, Kamalika

doi:10.1016/j.saa.2021.120322

Cited by 7 publications

(4 citation statements)

References 40 publications

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“…This paper describes the use of a portable RS to detect the changes in skin biochemical composition in the presence of the CHF disease. Several research teams [39][40][41][42][43][44][45][46][47] have analyzed the possibility of optical methods to detect different diseases based on the study of human biochemicals mainly in urine, blood serum, plasma blood or whole blood. Among various optical methods, RS has demonstrated its prospects to track changes in chemical composition with the accuracy close to the current laboratory techniques.…”

Section: Advantages and Disadvantages Of The Proposed Rs Approach For...mentioning

confidence: 99%

Raman spectroscopy in chronic heart failure diagnosis based on human skin analysis

Khristoforova

Bratchenko

Skuratova

et al. 2023

Journal of Biophotonics

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This work aims at studying Raman spectroscopy in combination with chemometrics as an alternative fast noninvasive method to detect chronic heart failure (CHF) cases. Optical analysis is focused on the changes in the spectral features associated with the biochemical composition changes of skin tissues. A portable spectroscopy setup with the 785 nm excitation wavelength was used to record skin Raman features. In this in vivo study, 127 patients and 57 healthy volunteers were involved in measuring skin spectral features by Raman spectroscopy. The spectral data were analyzed with a projection on the latent structures and discriminant analysis. 202 skin spectra of patients with CHF and 90 skin spectra of healthy volunteers were classified with 0.888 ROC AUC for the 10-fold cross validated algorithm. To identify CHF cases, the performance of the proposed classifier was verified by means of a new test set that is equal to 0.917 ROC AUC.

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Section: Advantages and Disadvantages Of The Proposed Rs Approach For...mentioning

confidence: 99%

Raman spectroscopy in chronic heart failure diagnosis based on human skin analysis

Khristoforova

Bratchenko

Skuratova

et al. 2023

Journal of Biophotonics

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“…This disease often affects large and small blood vessels as well as peripheral nerves, resulting in long-term damage, functional impairments, and failure of different organs including the eyes, kidneys, nerves, and blood vessels [2,3]. These effects result in conditions such as retinopathy, renal failure [4], diabetic foot [5], diabetic neuropathy [6], and diabetic osteopathy [7], which significantly impact an individual's health and quality of life. According to the 2021 Global Diabetes Map data released by the International Diabetes Federation, the global prevalence rate of DM among the 20-79-yearold age group was approximately 10.5% (536.6 million people) in 2021, and it is estimated that the rate will increase to approximately 12.2% (783.2 million people) by 2045 [8].…”

Section: Introductionmentioning

confidence: 99%

Nourishing Yin traditional Chinese medicine: potential role in the prevention and treatment of type 2 diabetes

Dai

2024

Am J Transl Res

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Type 2 diabetes mellitus (T2DM), a common and frequently occurring disease in contemporary society, has become a global health threat. However, current mainstream methods of prevention and treatment, mainly including oral hypoglycemic drugs and insulin injections, do not fundamentally block the progression of T2DM. Therefore, it is imperative to find new ways to prevent and treat diabetes. Traditional Chinese medicine is characterized by multiple components, pathways, and targets with mild and long-lasting effects. Pharmacological studies have shown that nourishing yin traditional Chinese medicine (NYTCM) can play a positive role in the treatment of T2DM by regulating pathways such as the phosphatidylinositol 3-kinase/serine-threonine kinase, mitogen-activated protein kinase, nuclear factor-kappa B, and other pathways to stimulate insulin secretion, protect and repair pancreatic β cells, alleviate insulin resistance, ameliorate disordered glucose and lipid metabolism, mitigate oxidative stress, inhibit inflammatory responses, and regulate the intestinal flora. The pharmacologic activity, mechanisms, safety, and toxicity of NYTCM in the treatment of T2DM are also reviewed in this manuscript.

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“…Currently, there are few treatments for DN, most of which include many side effects. In previous investigations, the results of melatonin [ 14 , 15 ], caffeine [ 16 ], capsaicin [ 17 ], vitamin B 12 [ 18 ], alpha-lipoic acid [ 19 ], vitamin E [ 20 ], acupuncture [ 21 ], gabapentin and duloxetine [ 22 , 23 ], pregabalin and gabapentin [ 24 ], gabapentin [ 25 , 26 ], the topical combination of clonidine and pentoxifylline [ 27 ], and clonidine gel with capsaicin cream has been studied [ 28 ]. Anticonvulsants are common medications for treating peripheral neuropathy but are not sufficiently compelling and include side effects [ 29 ].…”

Section: Introductionmentioning

confidence: 99%

Effectiveness of oral clonidine and gabapentin on peripheral neuropathy in diabetic patients in southwestern Iran: a randomized clinical trial

Hassanzadeh,

Bagheri,

Majid Ahmadi

et al. 2023

BMC Endocr Disord

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Background Peripheral neuropathy is not only the most prevalent consequence of diabetes but also the main reason for foot ulceration, disability, and amputation. Therefore, the current study aims to determine the effectiveness of oral clonidine and gabapentin on peripheral neuropathy in diabetic patients. Methods This 12-week, randomized, and parallel-group trial was conducted to compare the efficacy of oral clonidine and gabapentin with gabapentin alone in diabetic patients in southwest Iran during the first half of 2021. Thirty patients with type 2 diabetes with peripheral neuropathy as assessed by a visual analog scale (VAS) and divided into two groups of 15 patients, treated for up to three months. The data were analyzed using SPSS-21 software. In order to report the results, descriptive indices, independent t-test, one-way analysis of covariance (ANCOVA) and analysis of variance with repeated measures were used. Results The mean and standard deviation of the age of the participants in the clonidine + gabapentin group was equal to 50.20 ± 7.44, and in the gabapentin group was equal to 50.47 ± 7.57 (t = 0.10, P-value = 0.923). This research showed a significant difference between the clonidine + gabapentin group and with gabapentin group in terms of neuropathic pain and the severity of neuropathic pain (P < 0.001). Conclusions According to this research results, clonidine + gabapentin can reduce neuropathic pain and the severity of neuropathic pain in diabetic patients. Therefore, it is recommended that healthcare professionals with diabetes expertise prescribe these medications to reduce neuropathic pain and its severity. Trial registration This study was registered in the Iranian Clinical Trials System with the ID (IRCT20211106052983N1) on 14/01/2022.

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Effect of caffeine on the possible amelioration of diabetic neuropathy: A spectroscopic study

Cited by 7 publications

References 40 publications

Raman spectroscopy in chronic heart failure diagnosis based on human skin analysis

Raman spectroscopy in chronic heart failure diagnosis based on human skin analysis

Nourishing Yin traditional Chinese medicine: potential role in the prevention and treatment of type 2 diabetes

Effectiveness of oral clonidine and gabapentin on peripheral neuropathy in diabetic patients in southwestern Iran: a randomized clinical trial

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