Effect of calcium and vitamin D supplementation on bone mineral density in women aged 65–71 years: a 3-year randomized population-based trial (OSTPRE-FPS)

Kärkkäinen, Miia; Tuppurainen, Marjo; Salovaara, Kari; Sandini, Lorenzo; Rikkonen, Toni; Sirola, Joonas; Honkanen, Risto; Jurvelin, Jukka S.; Alhava, Esko; Kröger, Heikki

doi:10.1007/s00198-009-1167-8

Cited by 61 publications

(63 citation statements)

References 37 publications

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“…This effect is comparable to that of calcium and vitamin D supplementation as recently shown also by Kärkkäinen et al (2010) It appears, therefore, that a nutritional approach to postmenopausal alteration in bone metabolism might be a valuable measure in the primary prevention of osteoporosis. Nicklas et al (2009) recommend 3 to 4 servings from the dairy group of foods to all people older than 9 yr of age as a way to ensure adequate intake of calcium and magnesium.…”

Section: Benefits From Milk: Some Experimental Detailssupporting

confidence: 71%

Invited review: Dairy intake and bone health: A viewpoint from the state of the art

Caroli

Poli²,

Ricotta

et al. 2011

Journal of Dairy Science

143

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Section: Benefits From Milk: Some Experimental Detailssupporting

confidence: 71%

Invited review: Dairy intake and bone health: A viewpoint from the state of the art

Caroli

Poli²,

Ricotta

et al. 2011

Journal of Dairy Science

143

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“…The subjects of this study were from the Kuopio Fracture Prevention Study (OSTPRE-FPS) started in 2002 (Kärkkäinen et al, 2010). The OSTPRE-FPS study is a 3-year intervention on the effects of calcium and vitamin D supplements on falls and fractures among postmenopausal women over the age of 65.…”

Section: Subjectsmentioning

confidence: 99%

“…The subjects were drawn from the population-based OSTPRE-cohort. In total 3432 women volunteered to participate in the study (Kärkkäinen et al, 2010). A sub sample (n ¼ 750) of the OSTPRE-FPS participants were invited to participate in specific measurements including BMD, several clinical, physical and laboratory tests.…”

Section: Subjectsmentioning

confidence: 99%

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Associations of dietary polyunsaturated fatty acids with bone mineral density in elderly women

et al. 2011

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Background/Objectives: Significance of dietary fatty acids on bone health is not clear, and the evidence is controversial. This study aimed to investigate the relationship between dietary polyunsaturated fatty acids (PUFAs) and bone mineral density (BMD) among elderly women. Subjects/Methods: Subjects (n ¼ 554) were drawn from the Kuopio OSTPRE Fracture Prevention Study. At baseline they filled a 3-day food record and a questionnaire on lifestyle factors, diseases and medications. BMD was measured at lumbar spine (L2-L4), femoral neck and total body by dual energy X-ray absorptiometry at baseline and after 3 years. The associations between dietary fatty acids and BMD were analyzed by a linear mixed model adjusting for potential dietary and non-dietary confounders. Results: Our findings suggested a positive relationship between the dietary PUFAs and BMD at lumbar spine and in total body but not at femoral neck. Further analyses revealed that these results were due to associations among the women without hormone therapy (HT) at baseline. Among them, the intake of total PUFAs as well the intakes of linoleic and linolenic acids and total n-3 and n-6 fatty acids were significantly associated with BMD at lumbar spine; P for trend over the quartiles ranged between 0.013 and 0.001. Similarly, significant associations were demonstrated for total body BMD and fatty acids with an exception of total PUFA. No significant associations were found among women with HT at baseline. Conclusions: Our findings among elderly women without HT support the suggested beneficial effect of dietary PUFAs on bone health.

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“…For example, in our study [10] the mean dairy, total nutritional and total Ca intakes have been on average 800, 1100 and 1200 mg/day, respectively, during the last 20 years. Awareness of risk factors has also improved.…”

Section: Bone Mineral Density Effectsmentioning

confidence: 45%

Calcium and Vitamin D in Promotion of Postmenopausal Bone Health

Kröger

Kärkkäinen

Honkanen

2010

Womens Health (Lond Engl)

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Effect of calcium and vitamin D supplementation on bone mineral density in women aged 65–71 years: a 3-year randomized population-based trial (OSTPRE-FPS)

Abstract: daily vitamin D and calcium supplementation have a positive effect on the skeleton in ambulatory postmenopausal women with adequate nutritional calcium intake.

Cited by 61 publications

References 37 publications

Invited review: Dairy intake and bone health: A viewpoint from the state of the art

Invited review: Dairy intake and bone health: A viewpoint from the state of the art

Associations of dietary polyunsaturated fatty acids with bone mineral density in elderly women

Calcium and Vitamin D in Promotion of Postmenopausal Bone Health

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