Effect of caloric restriction with and without exercise training on oxidative stress and endothelial function in obese subjects with type 2 diabetes

Wycherley, Thomas P.; Brinkworth, Grant D.; Noakes, M.; Buckley, Jonathan D.; Clifton, Peter M.

doi:10.1111/j.1463-1326.2008.00863.x

Cited by 99 publications

(101 citation statements)

References 72 publications

(93 reference statements)

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“…Reductions in inflammatory markers such as CRP and IL-6 have even been observed after weight loss as little as 5% (Imayama et al, 2012), although Madsen et al (2008) found that over a 3-year period weight loss needed to exceed 10% to induce a significant improvement in inflammatory markers. Weight loss is also associated with reduced markers of oxidative stress such isoprostane, thiobarbituric acid reactive substances and malondialdehyde (Boesing et al, 2010, Bougoulia et al, 2006, Ozcelik et al, 2005, Wycherley et al, 2008, and increased antioxidant enzymes such as glutathione peroxidase and catalase (Boesing et al, 2010, Bougoulia et al, 2006.…”

Section: Does Weight Loss Improve Dysregulated Pathways Associated Wimentioning

confidence: 99%

Obesity and psychiatric disorders: Commonalities in dysregulated biological pathways and their implications for treatment

Lopresti

Drummond

2013

Progress in Neuro-Psychopharmacology and Biological Psychiatry

196

128

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Rates of obesity are higher than normal across a range of psychiatric disorders, including major depressive disorder, bipolar disorder, schizophrenia and anxiety disorders. While the problem of obesity is generally acknowledged in mental health research and treatment, an understanding of their bi-directional relationship is still developing. In this review the association between obesity and psychiatric disorders is summarised, with a specific emphasis on similarities in their disturbed biological pathways; namely neurotransmitter imbalances, hypothalamus-pituitary-adrenal axis disturbances, dysregulated inflammatory pathways, increased oxidative and nitrosative stress, mitochondrial disturbances, and neuroprogression. The applicability and effectiveness of weight-loss interventions in psychiatric populations is reviewed along with their potential efficacy in ameliorating disturbed biological pathways, particularly those mediating inflammation and oxidative stress. It is proposed that weight loss may not only be an effective intervention to enhance physical health but may also improve mental health outcomes and slow the rate of neuroprogressive disturbances in psychiatric disorders. Areas of future research to help expand our understanding of the relationship between obesity and psychiatric disorders are also outlined.

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Section: Does Weight Loss Improve Dysregulated Pathways Associated Wimentioning

confidence: 99%

Obesity and psychiatric disorders: Commonalities in dysregulated biological pathways and their implications for treatment

Lopresti

Drummond

2013

Progress in Neuro-Psychopharmacology and Biological Psychiatry

196

128

View full text Add to dashboard Cite

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“…The 12-week intervention lead to a significant reduction of malondialdehyde (p ≤ 0.05) and an increase of urinary nitrite/nitrate (p < 0.01) in both groups [45]. The total antioxidant capacity slightly increased with both interventions (p < 0.08) [45].…”

Section: Resultsmentioning

confidence: 99%

“…Wycherley et al [45] conducted another study that compared a diet intervention with and without aerobic exercise training in overweight and obese subjects with type 2 diabetes. The 12-week intervention lead to a significant reduction of malondialdehyde (p ≤ 0.05) and an increase of urinary nitrite/nitrate (p < 0.01) in both groups [45].…”

Section: Resultsmentioning

confidence: 99%

“…We identified 15 studies investigating the effect of weight loss interventions (diet- and/or exercise-, and surgery-induced) on individuals' oxidative stress level (table 1): 6 RCTs and 9 non-randomized intervention studies (n = 5 diet, n = 6 diet and/or exercise interventions, and n = 3 bariatric surgery interventions) [35,36,37,38,39,40,41,42,43,44,45,46,47,48]. All studies measured oxidative stress markers in blood samples (plasma or serum, e.g., enzyme activities, 8-isoprostane, 8-oxo-dG; for details see table 1) [35,36,37,38,39,40,41,42,43,44,45,46,47,48].…”

Section: Resultsmentioning

confidence: 99%

“…All studies measured oxidative stress markers in blood samples (plasma or serum, e.g., enzyme activities, 8-isoprostane, 8-oxo-dG; for details see table 1) [35,36,37,38,39,40,41,42,43,44,45,46,47,48]. …”

Section: Resultsmentioning

confidence: 99%

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Effects of Intentional Weight Loss on Markers of Oxidative Stress, DNA Repair and Telomere Length - a Systematic Review

2017

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Background: Altered levels of markers of oxidative stress, DNA repair, and telomere integrity have been detected in obese individuals and may underlie the pathogenesis of obesity-related diseases. However, whether or not such effects are reversed by intentional weight loss has not been systematically reviewed. Methods: A literature search in PubMed/Medline identified 2,388 articles of which 21 studies (randomized controlled trial (RCT) (n = 10) and non-randomized intervention studies (n = 11)) were classified as testing the effects of intentional weight loss on i) oxidative stress (n = 15), ii) DNA repair (n = 2), and iii) telomere length (n = 4). Results: Across a broad range of intervention designs, diet-, exercise-, surgery-, balloon-induced weight loss regimens decreased oxidative stress measures. Studies investigating DNA repair capacity or telomere length as endpoints after weight loss were less common in number and yielded null or inconsistent results, respectively. Conclusion: While this systematic review supports a role for intentional weight loss in reducing obesity-associated oxidative stress, it is not clear whether the effects are primary outcomes or secondary to improvement in obesity-associated insulin resistance and/or chronic inflammation. Although the lack of effect of intentional weight loss on DNA repair capacity might be anticipated given that oxidative stress is reduced, additional studies are needed. The inconsistent effects of weight loss on telomere length or DNA repair suggest the need for a re-assessment of intervention designs and assay methodology to definitively address this topic.

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Current literature in diabetes

2009

Diabetes Metabolism Res

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In order to keep subscribers up‐to‐date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of diabetes/metabolism. Each bibliography is divided into 26 sections: 1 Reviews; 2 General; 3 Genetics; 4 Epidemiology; 5 Immunology; 6 Obesity; 7 Prediction and Prevention; 8 Intervention: a) General; b) Care; c) Drug Therapy; d)Economics; e) Gene therapy; f) Nursing; g) Nutrition; h) Surgery; i) Transplantation; 9 Pathology and Complications: a) General; b) Cardiovascular; c) Eye disease; d) Gestational and fetal; e) Neurological; f) Podiatrical; g) Renal; 10 Endocrinology & Metabolism; 11 Experimental Studies; 12 Diagnosis and Techniques. Within each section, articles are listed in alphabetical order with respect to author

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Effect of caloric restriction with and without exercise training on oxidative stress and endothelial function in obese subjects with type 2 diabetes

Abstract: These results suggest that lifestyle interventions incorporating diet with or without exercise improve glycaemic control, reduce oxidative stress and improve other cardiovascular risk factors but do not improve FMD in obese subjects with type 2 diabetes.

Cited by 99 publications

References 72 publications

Obesity and psychiatric disorders: Commonalities in dysregulated biological pathways and their implications for treatment

Obesity and psychiatric disorders: Commonalities in dysregulated biological pathways and their implications for treatment

Effects of Intentional Weight Loss on Markers of Oxidative Stress, DNA Repair and Telomere Length - a Systematic Review

Current literature in diabetes

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