Effect of Campylobacter fetus on in vitro fertilization and embryonic development of preimplantation bovine embryos

Cagnoli, Claudia Inés; Chiapparrone, María Laura; Cacciato, Claudio Santiago; Rodríguez, Marcelo Gastón; Catena, María del Carmen; Aller, Juan Florencio

doi:10.1016/j.vetmic.2023.109925

Veterinary Microbiology

2024

DOI: 10.1016/j.vetmic.2023.109925

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Effect of Campylobacter fetus on in vitro fertilization and embryonic development of preimplantation bovine embryos

Claudia Inés Cagnoli,

María Laura Chiapparrone,

Claudio Santiago Cacciato

et al.

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2024

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Campylobacter fetus isolates from both human patients and healthy cattle carry three distinct cytolethal distending toxin (cdt) gene clusters

WEN,

HATANAKA,

SOMROOP

et al. 2024

J. Vet. Med. Sci.

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Campylobacter fetus is a zoonotic pathogen. Although the precise virulence mechanisms have not yet been fully elucidated, cytolethal distending toxin (CDT) is considered as one of the well-characterized virulence factors in Campylobacter . In silico analysis of the genome of C. fetus type strain ATCC27374 T indicates that there are three cdt gene clusters, Cfcdt-I , Cfcdt-II and Cfcdt-III . However, it is not clear whether these clusters are ubiquitously present in C. fetus and their association with diseases in humans and animals. In this study, we have analyzed the distribution and nucleotide sequences of these cdt gene clusters in 137 C. fetus strains isolated from human patients and healthy cattle. MLST and PFGE were also applied to determine clonal relationship between C. fetus strains isolated from patients and cattle. We found all C. fetus strains carry three Cfcdt gene clusters by colony hybridization assay and the strains belonged to 38 different pulsotypes. Whole genome sequencing of 38 C. fetus strains was carried out to determine the entire cdt gene cluster sequences and their sequence type (ST). Among 38 strains, six STs were identified, and each cdt gene cluster showed high similarity (>99%). Interestingly, some of these Cfcdt genes are more similar to the cdt genes of other Campylobacter species than other Cfcdt gene types. Altogether, the results suggest that three Cfcdt gene clusters are highly conserved in C. fetus and the strains belonging to ST-6 may be more pathogenic to human.

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Campylobacter fetus isolates from both human patients and healthy cattle carry three distinct cytolethal distending toxin (cdt) gene clusters

WEN,

HATANAKA,

SOMROOP

et al. 2024

J. Vet. Med. Sci.

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show abstract

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Effect of Campylobacter fetus on in vitro fertilization and embryonic development of preimplantation bovine embryos

Cited by 1 publication

References 20 publications

<i>Campylobacter fetus</i> isolates from both human patients and healthy cattle carry three distinct cytolethal distending toxin (<i>cdt</i>) gene clusters

<i>Campylobacter fetus</i> isolates from both human patients and healthy cattle carry three distinct cytolethal distending toxin (<i>cdt</i>) gene clusters

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