Effect of cancer stage on health-related quality of life of patients with epithelial ovarian cancer

Techata, Apichaya; Muangmool, Tanarat; Wongpakaran, Tinakon; Charoenkwan, Kittipat

doi:10.1080/01443615.2021.1877647

Cited by 7 publications

(4 citation statements)

References 20 publications

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“…Low quality of life, especially in the area of physical and emotional functioning, and susceptibility to mood disorders, were presented by patients in the study by Shirala et al [ 17 ]. Deterioration of quality of life in women with ovarian cancer was also observed by Chase et al [ 18 ], Tachata et al [ 19 ], Słoniewski et al (platinum-based chemotherapy) [ 20 ], Lee et al [ 21 ], Sarkar et al [ 22 ], Śniadecki et al (intraperitoneal chemotherapy—IPC) [ 23 ], Bhugwandass et al (chemotherapy type: carboplatin–paclitaxel, cisplatin–paclitaxel, cisplatin–etoposide, and cyclophosphamide–carboplatin) [ 24 ], and Perkowska et al [ 25 ] as a result of chemotherapy. In a study by Lee et al [ 26 ], only 15% (out of approximately 948) of patients indicated improved quality of life after completion of platinum-based chemotherapy.…”

Section: Discussionsupporting

confidence: 63%

“…Chase et al [ 18 ], Friendlander et al [ 38 ], Tachata et al [ 19 ] (disease stage adversely affected the gastrointestinal variable in the patients), and Zhou et al [ 35 ] also observed the impact of the disease stage on quality of life. In contrast, Koole et al [ 39 ], who evaluated the effect of intraperitoneal hyperthermia chemotherapy in Stage III ovarian cancer, showed no negative impact on quality of life.…”

Section: Discussionmentioning

confidence: 99%

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Quality of Life for Polish Women with Ovarian Cancer during First-Line Chemotherapy

Bączyk,

Pleszewa,

Formanowicz

et al. 2023

Healthcare

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Ovarian cancer is the worst prognostic gynaecological cancer and represents a grave clinical and social problem. Therefore, the study aimed to assess female patients’ emotional, cognitive, physical, and social quality of life. The study included 100 patients diagnosed with ovarian cancer and treated with chemotherapy in a day hospital setting at the Department of Radiotherapy and Gynaecological Oncology at the Wielkopolska Oncology Centre in Poznań. The patients were given a standard treatment regimen: paclitaxel 175 mg/m2 in a 3 h infusion and carboplatin at an AUC of 6 (5–7) following Calvert as a 1 h infusion for six cycles administered every 21 days. In addition, standardised questionnaires of the Polish version of the EORTC QLQ-C30 and QLQOV28 were used. The analysis of the collected material shows that the patients reported the highest level of general health and quality of life at the study’s first stage, i.e., before chemotherapy (mean value of 59.67 points). In contrast, the patients’ lowest level of general health and quality of life was observed in the fourth stage of the study (mean value of 45.04 points). The problem of side effects, such as nausea and vomiting, affected the entire study group and was more troublesome in the final stage of treatment for all patients. In the study’s first stage, the mean score on the nausea and vomiting symptom scale was 16 points; in the fourth stage, the mean score was 40.07. Of the clinical factors, the symptom of fatigue was the most severe health problem for the subjects. The mean score of the fatigue scale in the study’s first stage was 37.11 points, while a score of 70.33 was obtained in the fourth stage of the research. The multivariate linear regression model showed that the lack of professional activity lowers quality of life, especially combined with other side effects of chemotherapy, including hair loss in Stage IV of the study. This study shows that women with ovarian cancer undergoing chemotherapy need exceptional support from psychologists, nurses, dieticians, and physiotherapists.

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Section: Discussionsupporting

confidence: 63%

Section: Discussionmentioning

confidence: 99%

Quality of Life for Polish Women with Ovarian Cancer during First-Line Chemotherapy

Bączyk,

Pleszewa,

Formanowicz

et al. 2023

Healthcare

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“…Stage IV breast cancer patients had lower physical functioning, sexual functioning, sexual enjoyment and more arm symptom as compared to stage I breast cancer patients. In line with this study, another study reported that patients with advanced stage of cancer had unfavorable QoL scales [35] and patients with early stage of cancer showed higher functional score and lower symptom score [36]. Age had no significant association with EORTC QLQ-C30 symptom scales.…”

Section: Factors Associated To Qol Of Breast Cancer Patientssupporting

confidence: 71%

Quality of life and its influencing factors among breast cancer patients at Tikur Anbessa specialised hospital, Addis Ababa, Ethiopia

et al. 2022

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Background Quality of life (QoL) has become an important measure for evaluating cancer patients’ treatment and prognosis. Breast cancer patients are at an increased risk of experiencing poor QoL during active treatment of cancer. This study aimed to assess QoL and it’s influencing factors among breast cancer patients using the newly updated breast cancer specific tool of the European Organisation for Research and Treatment of Cancer EORTC Breast Cancer Specific Quality of Life Questionnaire QLQ-BR45. Methods An institutional based crossectional study was conducted with 248 breast cancer patients at Tikur Anbessa Specialized Hospital (TASH). Descriptive statistics, one-way analysis of variance (ANOVA), and linear regression were used to describe and analyze the data. Results The participant’s Global health status/QoL mean score was 65.6. Among the functional scales, future perspective scored the lowest (57.1, SD ± 37.3). The highest mean score on the symptom scales/items were financial difficulties (50, SD ± 38.6), followed by appetite loss (37.4, SD ± 36.4) and fatigue (34.3, SD ± 27.1) while the lowest symptom score was diarrhoea (6.4 ± 18.4). EORTC QLQ-BR45, future perspective (mean = 57.1, SD ± 37.3) and upset by hair loss (41.8, SD ± 34.6) were the most affected functioning and symptoms scales respectively. An increased stage of tumor was associated with more pain (P = 0.041), appetite loss (P = 0.042), and arm symptoms (P = 0.003). Patients who had no comorbidity had better physical (P < 0.001), cognitive (P = 0.013), and social (P = 0.009) function. Conclusion These specific functional scales and symptoms should be assessed individually to address unmet needs. Clinicians could design psychosocial interventions to improve these function and to reduce symptoms.

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“…, Tachata et al [17] (disease stage adversely affected the gastrointestinal part in the patients) and Zhou et al [35] also observed the impact of the disease stage on quality of life. In contrast, Koole et al [39], who evaluated the effect of intraperitoneal hyperthermia chemotherapy in stage III ovarian cancer, showed no negative impact on quality of life.…”

Section: Chase Et Al [16] Friendlander Et Al [38]mentioning

confidence: 97%

Quality of life in women with ovarian cancer during first-line chemotherapy concerning the age of the patients

Bączyk,

Pleszewa,

Formanowicz

et al. 2023

Preprint

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Ovarian cancer is the worst prognostic gynaecological cancer and represents a grave clinical and social problem. Therefore, the study aimed to assess female patients' emotional, cognitive, physical and social quality of life. The study included 100 patients diagnosed with ovarian cancer and treated with chemotherapy in a day hospital setting in the Department of Radiotherapy and Gynaecological Oncology at the Wielkopolska Oncology Centre Poznań. The patients obtained a standard treatment regimen: paclitaxel 175 mg/m² in a 3-hourly infusion and carboplatin at an AUC of 6 (5–7) following Calvert as a 1-hour infusion for six cycles administered every 21 days. In addition, the standardised questionnaires of the Polish version of the EORTC QLQ-C30 and QLQOV28 were used. The analysis of the collected material shows that the patients reported the highest level of general health and quality of life at the study's first phase, i.e. before the start of chemotherapy (mean value 59.67 points). In contrast, the patients' lowest level of general health and quality of life was observed in the fourth phase of the study (mean value of 45.04 points). Detailed data analysis shows that the patients scored highest in the four study phases regarding cognitive functioning. The mean value in the first phase of the study was 77 points. While in the fourth phase of the study, it was 57.98 points. The study indicates that the patients in social functioning represented the lowest quality of life throughout the study process - the numerical mean on the social functioning scale. In the first phase, there were 63.50 points; in the fourth phase, 35.11 points. The problem of side effects, such as nausea and vomiting, affected the entire study group and was more troublesome in the final stage of treatment for all patients. In the study's first phase, the mean score on nausea and vomiting symptom scale was 16 points; in the fourth phase, the mean score was 40.07. Of the clinical factors, the symptom of fatigue was the most severe health problem for the subjects. The mean score of the fatigue scale in the study's first phase was 37.11 points, while a score of 70.33 was obtained in the fourth phase of the research. Women with ovarian cancer during chemotherapy need exceptional support from psychologists, nurses, dieticians and physiotherapists.

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Effect of cancer stage on health-related quality of life of patients with epithelial ovarian cancer

Cited by 7 publications

References 20 publications

Quality of Life for Polish Women with Ovarian Cancer during First-Line Chemotherapy

Quality of Life for Polish Women with Ovarian Cancer during First-Line Chemotherapy

Quality of life and its influencing factors among breast cancer patients at Tikur Anbessa specialised hospital, Addis Ababa, Ethiopia

Quality of life in women with ovarian cancer during first-line chemotherapy concerning the age of the patients

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