Effect of Cannabis sativa extract on gastric acid secretion, oxidative stress and gastric mucosal integrity in rats

Abdel-Salam, Omar M.E.; Salama, Rania A. A.; El-Denshary, Ezz-El-Din S.; Sleem, Amany A.; El-Shamarka, Marawa El-Sayed; Hassan, Nabila S.

doi:10.1007/s00580-015-2090-3

Cited by 10 publications

(3 citation statements)

References 45 publications

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“…Chronic inflammation is a known risk factor for cancer development, and CBD's ability to mitigate inflammation could contribute to its potential as an adjuvant therapy for gastric cancer. It has been shown that in a rat model, Cannabis extract increased the antioxidant mechanisms in terms of drug-induced oxidative stress (stimulation of gastric acid secretion with carbachol, pentagstrin, or histamine) [97]. Pre-treatment with Cannabis, administered subcutaneously in doses of 5, 10, and 20 mg/kg, increased GSH content compared to the control group, leading to decreased gastric mucosal damage [97].…”

Section: Gastric Cancermentioning

confidence: 99%

“…It has been shown that in a rat model, Cannabis extract increased the antioxidant mechanisms in terms of drug-induced oxidative stress (stimulation of gastric acid secretion with carbachol, pentagstrin, or histamine) [97]. Pre-treatment with Cannabis, administered subcutaneously in doses of 5, 10, and 20 mg/kg, increased GSH content compared to the control group, leading to decreased gastric mucosal damage [97]. It has also been suggested that the protective role of Cannabis sativa extract might be elucidated by its ability to reduce inflammatory cytokine production [97].…”

Section: Gastric Cancermentioning

confidence: 99%

“…Pre-treatment with Cannabis, administered subcutaneously in doses of 5, 10, and 20 mg/kg, increased GSH content compared to the control group, leading to decreased gastric mucosal damage [97]. It has also been suggested that the protective role of Cannabis sativa extract might be elucidated by its ability to reduce inflammatory cytokine production [97].…”

Section: Gastric Cancermentioning

confidence: 99%

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Targeting Nrf2 Signaling Pathway in Cancer Prevention and Treatment: The Role of Cannabis Compounds

Rybarczyk,

Majchrzak-Celińska,

Krajka-Kuźniak

2023

Antioxidants

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The development and progression of cancer are associated with the dysregulation of multiple pathways involved in cell proliferation and survival, as well as dysfunction in redox balance, immune response, and inflammation. The master antioxidant pathway, known as the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway, regulates the cellular defense against oxidative stress and inflammation, making it a promising cancer prevention and treatment target. Cannabinoids have demonstrated anti-tumor and anti-inflammatory properties, affecting signaling pathways, including Nrf2. Increased oxidative stress following exposure to anti-cancer therapy prompts cancer cells to activate antioxidant mechanisms. This indicates the dual effect of Nrf2 in cancer cells—influencing proliferation and apoptotic processes and protecting against the toxicity of anti-cancer therapy. Therefore, understanding the complex role of cannabinoids in modulating Nrf2 might shed light on its potential implementation as an anti-cancer support. In this review, we aim to highlight the impact of cannabinoids on Nrf2-related factors, with a focus on cancer prevention and treatment. Additionally, we have presented the results of several research studies that combined cannabidiol (CBD) with other compounds targeting Nrf2. Further studies should be directed toward exploring the anti-inflammatory effects of cannabinoids in the context of cancer prevention and therapy.

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Section: Gastric Cancermentioning

confidence: 99%

Section: Gastric Cancermentioning

confidence: 99%

Section: Gastric Cancermentioning

confidence: 99%

See 1 more Smart Citation

Targeting Nrf2 Signaling Pathway in Cancer Prevention and Treatment: The Role of Cannabis Compounds

Rybarczyk,

Majchrzak-Celińska,

Krajka-Kuźniak

2023

Antioxidants

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Effects of ∆-9 tetrahydrocannabinol on the small intestine altered by high fructose diet: A Histopathological study

Isildar,

Beydogan,

Koyuturk

et al. 2024

Histochem Cell Biol

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The consumption of fructose is increasing day by day. Understanding the impact of increasing fructose consumption on the small intestine is crucial since the small intestine processes fructose into glucose. ∆9-Tetrahydrocannabinol (THC), a key cannabinoid, interacts with CB1 and CB2 receptors in the gastrointestinal tract, potentially mitigating inflammation. Therefore, this study aimed to investigate the effects of the high-fructose diet (HFD) on the jejunum of rats and the role of THC consumption in reversing these effects. Experiments were conducted on Sprague–Dawley rats, with the experimental groups as follows: control (C), HFD, THC, and HFD + THC. The HFD group received a 10% fructose solution in drinking water for 12 weeks. THC groups were administered 1.5 mg/kg/day of THC intraperitoneally for the last four weeks. Following sacrification, the jejunum was evaluated for mucus secretion capacity. IL-6, JNK, CB2 and PCNA expressions were assessed through immunohistochemical analysis and the ultrastructural alterations via transmission electron microscopy. The results showed that fructose consumption did not cause weight gain but triggered inflammation in the jejunum, disrupted the cell proliferation balance, and increased mucus secretion in rats. Conversely, THC treatment displayed suppressed inflammation and improved cell proliferation balance caused by HFD. Ultrastructural examinations showed that the zonula occludens structures deteriorated in the HFD group, along with desmosome shrinkage. Mitochondria were found to be increased due to THC application following HFD. In conclusion, the findings of this research reveal the therapeutic potential of THC in reversing HFD-related alterations and provide valuable insights for clinical application. Graphical abstract

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Role of herbal bioactives and their formulations in the treatment of gastrointestinal disorders

Kaur

Sachdeva

Singh

et al. 2022

Herbal Bioactive-Based Drug Delivery Systems

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Effect of Cannabis sativa extract on gastric acid secretion, oxidative stress and gastric mucosal integrity in rats

Cited by 10 publications

References 45 publications

Targeting Nrf2 Signaling Pathway in Cancer Prevention and Treatment: The Role of Cannabis Compounds

Targeting Nrf2 Signaling Pathway in Cancer Prevention and Treatment: The Role of Cannabis Compounds

Effects of ∆-9 tetrahydrocannabinol on the small intestine altered by high fructose diet: A Histopathological study

Role of herbal bioactives and their formulations in the treatment of gastrointestinal disorders

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