Effect of capsaicin on pharmacodynamic and pharmacokinetics of gliclazide in animal models with diabetes

Lagisetty, Umachandar; Habibuddin, Mohammed; Ramaiah, Sivakumar

doi:10.4103/pr.pr_81_18

Cited by 5 publications

(3 citation statements)

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“…Drugs like rifampicin affect the disposition of gliclazide in humans, with both pharmacokinetics and pharmacodynamics implications (Park et al, 2003). Other drugs for which there are significant interactions with gliclazide are efavirenz (AL-mohamadi et al, 2015), St. John's wort (Xu et al, 2008), Ayuslim herbal drug (Mandlem et al, 2014) and capsaicin (Lagisetty et al, 2018). However, some studies showed a lack of interactions with gliclazide (Delrat et al, 2002), among others.…”

Section: Discussionmentioning

confidence: 99%

Effect of dihydro-artemisinin on the pharmacokinetics of gliclazide in diabetic subjects

Ishaku¹,

Bakare-Odunola²,

Musa³

et al. 2020

Int. J. Bio. Chem. Sci

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Diabetic patients do have co-occurring diseases like malaria, especially in tropical regions. Hence, polypharmacy is sometimes unavoidable. Gliclazide is widely used in the treatment of non-insulin-dependent type 2 diabetes mellitus, while dihydro-artemisinin (DHA) is one of the most promising medications used in the treatment of malaria on account of its good efficacy and tolerability. The study evaluated the effect of DHA on the pharmacokinetics of gliclazide in diabetic patients. This is a single dose one-way, cross-over study in two periods, with each phase preceded by an overnight fast. Six subjects that passed inclusion criteria participated in the study. The volunteers acted as their control. Phase 1 of the study involved administering a single oral dose of 80 mg of gliclazide after an overnight fast. After a washout period of one week, 80 mg gliclazide and 120 mg DHA were co-administered. Serial blood samples were collected at time intervals throughout 24 h and processed. A validated HPLC method was used to estimate serum gliclazide concentration, while the glucose oxidase peroxidase method was used in the evaluation of blood glucose concentration. The Pharmacokinetic Software - PharmPK was used to generate the pharmacokinetic parameters. GraphPad Prism version 7.01 software for window was used for data analysis. Statistical differences observed in the pharmacokinetic profiles of gliclazide and blood glucose concentration were not significant. Single oral dose of gliclazide and dihydro-artemisinin had good safety and tolerability in diabetic subjects. Keywords: Diabetes mellitus, Dihydro-artemisinin, Drug Interactions, Gliclazide, Pharmacokinetics

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Section: Discussionmentioning

confidence: 99%

Effect of dihydro-artemisinin on the pharmacokinetics of gliclazide in diabetic subjects

Ishaku¹,

Bakare-Odunola²,

Musa³

et al. 2020

Int. J. Bio. Chem. Sci

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“…Diabetes mellitus was induced by administering alloxan monohydrate (150mg/kg) dissolved in standard saline solution was injected intravenously into the overnight fasted rabbits through the marginal ear vein 18 . Food was provided 2 h after injection.…”

Section: Induction Of Experimental Diabetes Mellitusmentioning

confidence: 99%

Untitled

2022

IJPSR

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The present study was carried out to investigate the hypoglycemic and hypolipidemic effect of Moringa oleifera leaf powder (MO) in alloxan-induced diabetic rabbits by administering oral doses (100, 200, and 400 mg/kg body weight). Diabetes was induced intravenously into rabbits with a single dose of alloxan (150 mg/kg). Diabetic rabbits were treated with MO (100, 200, and 400 mg/kg) and Glibenclamide (5 mg/kg/day). To determine fasting blood glucose, blood was drawn on days 1, 7, and 14, while it was drawn on day 14 for the determination of lipids, and relative body weight was measured at days 0 and 14. After 2 weeks of treatment, the fasting blood glucose levels of the MO-fed groups were significantly lower when compared with the diabetes mellitus (DM) group (P < 0.05), and the results were compared with standard Glibenclamide drug. Treatment with the MO also resulted in a significant decrease in serum total cholesterol, triglycerides, and low-density lipoprotein cholesterol (P< 0.05) accompanied by a significant increase in serum high-density lipoprotein cholesterol (P< 0.05). The overall results suggest that the MO possesses potential hypoglycemic and hypolipidemic activity in alloxan-induced diabetic rabbits. INTRODUCTION:Moringa oleifera (Moringaceae) is a fast-growing perennial species native to North-western India, now cultivated in many parts of the world. This species has been used in folk medicine for the treatment of diabetes 1-3 . Scientists have shown Moringa cures type 1 diabetes and type 2. Type 1 diabetes is when patients do not produce insulin, which maintains a level of blood glucose at the necessary standard value.

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“…55 La administración de 6 mg de capsaicina/kg peso en ratas con diabetes inducida redujo (p<0.01) un 61.9 % los niveles de glucosa en sangre y mostró niveles de insulina de 22.24 µIU/mL, mientras que en conejos con diabetes inducida, la misma dosis redujo (p<0.01) los niveles de glucosa en sangre un 54 % comparados con los grupos control. 56 Otra investigación reportó que el tratamiento de una fórmula alimentaria (con 0.01 % de capsaicina), administrada a ratones C57BL/KsJ-(db/db) con diabetes tipo 2 durante 7 semanas, suprimió el aumento de los niveles de glucosa en sangre en ayunas a partir de la tercera semana de intervención, restauró la tolerancia oral a la glucosa y mejoró la sensibilidad a la insulina. 57 Por otro lado, la administración de 200 mg/kg peso de extractos de semillas de C. annuum en ratones C57BL/KsJ con diabetes, redujo significativamente (p<0.001) los niveles de glucosa en ayunas, glucosa posprandial (120 min después de la administración), insulina y la hemoglobina glicosilada (HbA1c) el 21 %, 30 %, 29 % y 22 %, respectivamente.…”

Section: Efecto Antidiabéticounclassified

Composición y aplicaciones clínicas de especies de chiles (Capsicum spp.) domesticados

Osorio-Barraza

Manzur-Valdespino

Zafra-Rojas

et al. 2021

ICSA

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El género Capsicum es originario de América Latina y se expandió a otros continentes mediante intercambio de especias. Su fruto se utiliza fresco o seco para aportar color, sabor y olor a platillos, ensaladas y salsas. Posee gran relevancia comercial a nivel mundial, siendo los principales países productores China, México y Turquía. Existen cinco especies domesticadas que son: C. baccatum, C. chinense, C. pubescens, C. frutescens y C. annuum. En general, los frutos de Capsicum disponen de gran variedad de tamaños y formas, y de acuerdo a su estado de madurez presentan cambios en las tonalidades, que van del verde a tonos amarillos, rojos y rojos intensos. Los frutos poseen compuestos bioactivos que pueden proveer efectos benéficos en la salud. El objetivo del presente trabajo fue realizar una revisión sobre los compuestos bioactivos de las diferentes especies domesticadas del género Capsicum y sus recientes aplicaciones clínicas. Debido a los componentes bioactivos de las especies de Capsicum, los estudios demuestran efectos benéficos en la prevención y tratamiento sobre enfermedades no transmisibles, efectos antiinflamatorios, control de peso, cardiovasculares, antidiabéticos, gastrointestinales y cancerígenos. Las especies de Capsicum tienen un notable papel en el campo médico debido a su capacidad de modular y modificar diversos procesos a nivel biológico.

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Effect of capsaicin on pharmacodynamic and pharmacokinetics of gliclazide in animal models with diabetes

Cited by 5 publications

References 1 publication

Effect of dihydro-artemisinin on the pharmacokinetics of gliclazide in diabetic subjects

Effect of dihydro-artemisinin on the pharmacokinetics of gliclazide in diabetic subjects

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Composición y aplicaciones clínicas de especies de chiles (Capsicum spp.) domesticados

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