Effect of carbamylated erythropoietin Fc fusion protein (CEPO-Fc) on learning and memory impairment and hippocampal apoptosis induced by intracerebroventricular administration of streptozotocin in rats

Moosavi, Maryam; Hooshmandi, Etrat; Javadpour, Pegah; Maghsoudi, Nader; Katinger, Hermann; Ghasemi, Rasoul

doi:10.1016/j.bbr.2020.112554

Cited by 17 publications

(3 citation statements)

References 34 publications

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“…[179] 13) CEPO-Fc can restore streptozotocin (STZ)-induced learning and memory impairment as well as apoptosis in the hippocampal region in a rat model of sporadic AD induced by icv-STZ [180] 14) EPO pretreatment prolonged seizure latency and reduced seizure severity after PTZ-induced seizures, due to the protection of CA1 and CA3 neurons, possibly owing to SIRT1 and BDNF activity [181] 15) Erythropoietin can attenuate propofol-induced hippocampal neuronal cell injury in developing rats, which may be related to inhibit TLR4 expression [182] PD effects of EPO in neuroprotection, of which we refer to the last most significant experimental studies published in (Table 3).…”

mentioning

confidence: 99%

Hypoxia, Oxidative Stress, and Inflammation: Three Faces of Neurodegenerative Diseases

Merelli

Repetto

Lazarowski

et al. 2021

JAD

111

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The cerebral hypoxia-ischemia can induce a wide spectrum of biologic responses that include depolarization, excitotoxicity, oxidative stress, inflammation, and apoptosis, and result in neurodegeneration. Several adaptive and survival endogenous mechanisms can also be activated giving an opportunity for the affected cells to remain alive, waiting for helper signals that avoid apoptosis. These signals appear to help cells, depending on intensity, chronicity, and proximity to the central hypoxic area of the affected tissue. These mechanisms are present not only in a large list of brain pathologies affecting commonly older individuals, but also in other pathologies such as refractory epilepsies, encephalopathies, or brain trauma, where neurodegenerative features such as cognitive and/or motor deficits sequelae can be developed. The hypoxia inducible factor 1α (HIF-1α) is a master transcription factor driving a wide spectrum cellular response. HIF-1α may induce erythropoietin (EPO) receptor overexpression, which provides the therapeutic opportunity to administer pharmacological doses of EPO to rescue and/or repair affected brain tissue. Intranasal administration of EPO combined with other antioxidant and anti-inflammatory compounds could become an effective therapeutic alternative, to avoid and/or slow down neurodegenerative deterioration without producing adverse peripheral effects.

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mentioning

confidence: 99%

Hypoxia, Oxidative Stress, and Inflammation: Three Faces of Neurodegenerative Diseases

Merelli

Repetto

Lazarowski

et al. 2021

JAD

111

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“…(Ding et al, 2013) In a rat model of intracerebroventricular administration of streptozotocin, memory impairment and hippocampal apoptosis could also be ameliorated by CEPO. (Moosavi et al, 2020) CEPO was even effective in modulating cognitive function in mice with social defeat stress, which implied CEPO as a potential drug for treating neuropsychiatric diseases. (Sathyanesan et al, 2018) CEPO also achieved a few in Alzheimer's diseases (AD).…”

Section: An Overview Of the Tissue Protective Functions Of Epomentioning

confidence: 98%

Reevaluation of EPO and its Derivatives Centering on β Common Receptor

Luo,

Wang,

Yang

2024

Preprint

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EPO has been found to be protective to multiple injuries long time ago. Discovery of the so-called tissue protective receptor “EPOR/βcR” is astonishing among EPO researchers. βcR is a receptor subunit shared by IL-3/IL-5/GM-CSF and EPO, but no attention has been paid to these three cytokines in EPO research. This article unprecedentedly presented that potential relations between EPO and IL-3/IL-5/GM-CSF should be highly valued. We respectively compared GM-CSF and IL-3 to EPO/EPO derivatives, and summarized similar and opposite functions between these two cytokines and EPO/EPO derivatives. Here, drawbacks of the EPOR/βcR theory were deeply discussed and new hypothesis about the mechanism of EPO protection was proposed. In a word, referring to stagnation of EPO research and defects of current recognition, reassessment of our understandings about EPO’s protective function is of great urgency.

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“…In a fetal rat model of HIE, CEPO treatment suppressed the expression of pro-apoptotic protein cleaved caspase-3 (CC3) in the brain and regulated the Bcl-2/Bax ratio, resulting in reduced neuronal apoptosis ( Diao et al, 2019 ). Beyond cerebral ischemia, CEPO exhibited neuroprotective functions in other neurological diseases including AD ( Hooshmandi et al, 2018 ; Hooshmandi et al, 2020 ; Moosavi et al, 2020 ), PD ( Thomas Tayra et al, 2013 ), periventricular leukomalacia ( Liu et al, 2011 ), TBI ( Millet et al, 2016 ), spinal cord depression and hemisection ( King et al, 2007 ), and sciatic nerve compression ( Chen et al, 2015 ).…”

Section: Epo Derivative Treatment For Ischemic Strokementioning

confidence: 99%

The Effect of Erythropoietin and Its Derivatives on Ischemic Stroke Therapy: A Comprehensive Review

Zhou

Yang

et al. 2022

Front. Pharmacol.

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Numerous studies explored the therapeutic effects of erythropoietin (EPO) on neurodegenerative diseases. Few studies provided comprehensive and latest knowledge of EPO treatment for ischemic stroke. In the present review, we introduced the structure, expression, function of EPO, and its receptors in the central nervous system. Furthermore, we comprehensively discussed EPO treatment in pre-clinical studies, clinical trials, and its therapeutic mechanisms including suppressing inflammation. Finally, advanced studies of the therapy of EPO derivatives in ischemic stroke were also discussed. We wish to provide valuable information on EPO and EPO derivatives’ treatment for ischemic stroke for basic researchers and clinicians to accelerate the process of their clinical applications.

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Effect of carbamylated erythropoietin Fc fusion protein (CEPO-Fc) on learning and memory impairment and hippocampal apoptosis induced by intracerebroventricular administration of streptozotocin in rats

Cited by 17 publications

References 34 publications

Hypoxia, Oxidative Stress, and Inflammation: Three Faces of Neurodegenerative Diseases

Hypoxia, Oxidative Stress, and Inflammation: Three Faces of Neurodegenerative Diseases

Reevaluation of EPO and its Derivatives Centering on β Common Receptor

The Effect of Erythropoietin and Its Derivatives on Ischemic Stroke Therapy: A Comprehensive Review

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