Effect of carbetocin administration during the mid-period of parturition on farrowing duration, newborn piglet characteristics, colostrum yield and milk yield in hyperprolific sows

Vongsariyavanich, Suphannarat; Sundaraketu, Piracha; Sakulsirajit, Run; Suriyapornchaikul, Chakorn; Therarachatamongkol, Suphadtra; Boonraungrod, Naritsara; Pearodwong, Pachara; Tummaruk, Padet

doi:10.1016/j.theriogenology.2021.06.012

Cited by 16 publications

(18 citation statements)

References 26 publications

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“…In the present study, sows with prolonged farrowing had more stillborn piglets than sows with shorter farrowing duration. Therefore, various procedures to increase the uterine contractions of sows with large litters need to be comprehensively investigated [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

Factors Associated with Farrowing Duration in Hyperprolific Sows in a Free Farrowing System under Tropical Conditions

Adi

Boonprakob

Kirkwood

et al. 2022

Animals

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The ongoing selection for increased litter size has had significant impacts on sow husbandry practice. The present study investigated factors associated with farrowing duration and the proportion of sows that had prolonged farrowing in modern hyperprolific sows kept in a free farrowing system in a tropical environment. Farrowing data from 2493 Landrace x Yorkshire cross-bred sows in a commercial swine herd in Thailand were included in the study. The time of farrowing, parity number, litter size, and the birth status of each piglet were recorded. Farrowing duration was analysed using multiple analyses of variance. Total number of piglets born per litter (TB), parity, and time onset of farrowing were included in the statistical models. On average, TB, piglets born alive, and farrowing duration were 13.7, 12.1, and 221.0 min, respectively. Of these sows, 26.4% had TB ≥ 16 and 21.7% had a prolonged farrowing duration (≥300 min). Farrowing duration was positively correlated with TB (r = 0.141, p < 0.001), percentage of stillborn (SB) piglets per litter (r = 0.259, p < 0.001), percentage of mummified foetuses (MF) per litter (r = 0.049, p = 0.015), piglet birth weight (r = 0.068, p < 0.001), and litter birth weight (r = 0.041, p = 0.043). The proportion of SB per litter was higher and piglet birth weight lower in litters that had ≥16 TB than those with 8–12 TB (p < 0.05). The farrowing duration of sows with parity numbers 5–7 (247.7 ± 5.1 min) and 8–10 (237.1 ± 5.1 min) was longer than that of sows with parity numbers 1 (188.3 ± 5.2 min) and 2–4 (214.3 ± 3.9 min) (p < 0.05). Sows that had started farrowing during working hours had longer farrowing durations (229.3 ± 3.6 min) than those that had started farrowing during non-working hours (217.6 ± 3.4 min, p = 0.017). In multiparous sows, the duration of farrowing was positively correlated with the maximum temperature (r = 0.056, p = 0.012) and the maximum temperature–humidity index (r = 0.059, p = 0.008) in the 7 days before farrowing. The present data confirm that TB, sow parity, and time of onset of farrowing are significant risk factors for a prolonged farrowing.

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Section: Discussionmentioning

confidence: 99%

Factors Associated with Farrowing Duration in Hyperprolific Sows in a Free Farrowing System under Tropical Conditions

Adi

Boonprakob

Kirkwood

et al. 2022

Animals

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“…Carbetocin has also been shown to stimulate milk letdown due to its action on oxytocin receptors on the myoepithelial cells and there is not a significant amount of it in breast milk. Side effects are nausea, vomiting, chest pain, tachycardia, hypotension and respiratory distress (11) .…”

Section: Introductionmentioning

confidence: 99%

Carbetocin versus Oxytocin: A Comparative Study to Prevent Postpartum Hemorrhage in Pre-eclamptic Women Delivered by Caesarean Section

Anwar¹,

Salam²,

Esukni³

et al. 2022

The Egyptian Journal of Hospital Medicine

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Background: Postpartum hemorrhage and hypertensive disorders are the greatest contributors to maternal death in developing countries accounting for more than 50% of direct causes.Objective: This study aimed to improve the clinical outcomes of carbetocin versus oxytocin in preventing postpartum hemorrhage in women with pre-eclampsia during C aesarean Section (CS). Patients and methods: This study included 120 pre-eclamptic pregnant women and were randomized (by alternation) into two groups of 60 patients: Group A received a single dose of carbetocin (100μg) diluted in 100ml 0.9% Nacl administered slowly over (30-60 seconds) intravenously after the delivery of the baby, while Group B received oxytocin (40 IU diluted in 100ml of 0.9% Nacl run at 25 ml per hour over 4 hours) intravenously after the delivery of baby. Results: Regarding preoperative hemoglobin and HCT, there was no statistically significant difference between the 2 studied groups. There were statistical significant differences between the 2 groups in postoperative hemoglobin and HCT with higher levels among Group A compared with Group B. There was significant increase in frequency of blood transfusion and need of other uterotonic drugs in oxytocin group compared with carbetocin group. No significant difference was observed between the 2 studied groups in frequency of headache, but there were statistically significant increase in frequency of nausea, vomiting, abdominal pain and oligourea in oxytocin group compared to carbetocin group. There was significant increase in frequency of elevated temperature in carbetocine group compared to oxytocin group. Conclusion: Carbetocin has a superior effect on oxytocin for prevention of postpartum hemorrhage in women with pre-eclampsia.

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“…For modern hyperprolific sows in a tropical region, the average total number of piglets born, number of piglets born alive, number of stillborn piglets, and number of mummified foetuses were 17.2, 15.1, 1.3, and 0.8 piglets per litter, respectively (Vongsariyavanich et al, 2021). The average gestation length and farrowing duration of the modern hyperprolific sows in the tropics were 115.8 days and 310.3 min, respectively (Vongsariyavanich et al, 2021). The average body weights of piglets born alive and stillborn were 1203 and 968 g, respectively (Vongsariyavanich et al, 2021).…”

Section: Gestation and Lactation Managementmentioning

confidence: 99%

“…The average gestation length and farrowing duration of the modern hyperprolific sows in the tropics were 115.8 days and 310.3 min, respectively (Vongsariyavanich et al, 2021). The average body weights of piglets born alive and stillborn were 1203 and 968 g, respectively (Vongsariyavanich et al, 2021). In the tropics, the weaning‐to‐first‐service interval averaged 6.1−7.0 days in primiparous sows and 4.2−4.6 days in multiparous sows (Khamtawee et al, 2021).…”

Section: Gestation and Lactation Managementmentioning

confidence: 99%

“…However, seasonal variation on the farrowing rate of gilts and sows differed among herds (Tummaruk et al, 2010a). For modern hyperprolific sows in a tropical region, the average total number of piglets born, number of piglets born alive, number of stillborn piglets, and number of mummified foetuses were 17.2, 15.1, 1.3, and 0.8 piglets per litter, respectively (Vongsariyavanich et al, 2021). The average gestation length and farrowing duration of the modern hyperprolific sows in the tropics were 115.8 days and 310.3 min, respectively (Vongsariyavanich et al, 2021).…”

Section: Gestation and Lactation Managementmentioning

confidence: 99%

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Managing prolific sows in tropical environments

Tummaruk

Rensis

Kirkwood

2022

Molecular Reproduction Devel

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Litter size in modern sows has been dramatically improved in recent decades by genetic selection for highly prolific sows. In a tropical environment, the average total number of pigs born and number born alive are reported to be as high as 17.2 and 15.1 piglets per litter, respectively. Therefore, the new production target in many herds aims to achieve 30–40 pigs weaned per sow per year. Despite the improvements in litter size, the mean preweaning piglet mortality rate remains high, at between 10% and 20%, in major pig‐producing countries. A sufficient daily feed intake by lactating sows is important for high milk production as sow milk yield is the limiting factor for piglet growth rate. Heat stress, which can occur when the ambient temperatures rise above 25°C, is one of the major problems that decreases daily feed intake and compromises milk yield. Therefore, it is necessary to encourage high feed intakes to achieve high milk yields. However, even with high nutrient intakes, productivity can be constrained by intestinal barrier function, limiting digestive ability, and allowing potential pathogens and/or toxins to become systemic. This is more likely greater under tropical conditions because of heat stress, exacerbating sow fertility problems. Underpinning sow herd performance, including responses to environmental challenges, is the selection of appropriate gilts, for example, selection and management for early puberty, thus presumably selecting the more fertile gilts and the correct management of lactation to improve the number of weaned piglets are some of the key factors for future reproductive efficiency of the farm under tropical conditions.

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Effect of carbetocin administration during the mid-period of parturition on farrowing duration, newborn piglet characteristics, colostrum yield and milk yield in hyperprolific sows

Cited by 16 publications

References 26 publications

Factors Associated with Farrowing Duration in Hyperprolific Sows in a Free Farrowing System under Tropical Conditions

Factors Associated with Farrowing Duration in Hyperprolific Sows in a Free Farrowing System under Tropical Conditions

Carbetocin versus Oxytocin: A Comparative Study to Prevent Postpartum Hemorrhage in Pre-eclamptic Women Delivered by Caesarean Section

Managing prolific sows in tropical environments

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