Effect of Carbonate Contents on the Thermal Stability and Mechanical Properties of Carbonated Apatite Artificial Bone Substitute

Thang, Le Hong; Bang, L. T.; Long, Bui Duc; Son, Nguyen Anh; Ramesh, S.

doi:10.1007/s11665-022-07169-6

Cited by 8 publications

(3 citation statements)

References 48 publications

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“…− not being fully decomposed and incorporated into the apatite structure [74]. Consequently, hydroxyapatite in bones, typically doped with bicarbonate (so-called bone apatite), is characterised by easier solubility, facilitating dynamic bone remodelling [75,76].…”

Section: Stages Of Biomineralisationmentioning

confidence: 99%

Towards Polycaprolactone-Based Scaffolds for Alveolar Bone Tissue Engineering: A Biomimetic Approach in a 3D Printing Technique

Stafin,

Śliwa,

Piątkowski

2023

IJMS

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The alveolar bone is a unique type of bone, and the goal of bone tissue engineering (BTE) is to develop methods to facilitate its regeneration. Currently, an emerging trend involves the fabrication of polycaprolactone (PCL)-based scaffolds using a three-dimensional (3D) printing technique to enhance an osteoconductive architecture. These scaffolds are further modified with hydroxyapatite (HA), type I collagen (CGI), or chitosan (CS) to impart high osteoinductive potential. In conjunction with cell therapy, these scaffolds may serve as an appealing alternative to bone autografts. This review discusses research gaps in the designing of 3D-printed PCL-based scaffolds from a biomimetic perspective. The article begins with a systematic analysis of biological mineralisation (biomineralisation) and ossification to optimise the scaffold’s structural, mechanical, degradation, and surface properties. This scaffold-designing strategy lays the groundwork for developing a research pathway that spans fundamental principles such as molecular dynamics (MD) simulations and fabrication techniques. Ultimately, this paves the way for systematic in vitro and in vivo studies, leading to potential clinical applications.

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Section: Stages Of Biomineralisationmentioning

confidence: 99%

Towards Polycaprolactone-Based Scaffolds for Alveolar Bone Tissue Engineering: A Biomimetic Approach in a 3D Printing Technique

Stafin,

Śliwa,

Piątkowski

2023

IJMS

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“…However, the carbonate (CO3 2-) present in CA starts to decompose into CO2 gas at 50°C. There is a tendency to increase at 450-650°C, causing the product to decompose and weakening the mechanical properties [14], [16], [19], [22]. Therefore, the extrusion process is introduced to prevent carbonate decomposition [10], [11], [23], [24].…”

Section: Introductionmentioning

confidence: 99%

Composite of Magnesium and Carbonate Apatite for Biodegradable Bone Implants: A Comparative Study on Sintering and Extrusion Techniques

Setyadi,

Suryadi,

Jujur

et al. 2024

Int. J. Adv. Sci. Eng. Inf. Technol.

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Developing biodegradable bone implants using magnesium-based materials has garnered significant attention in research. Magnesium offers favorable properties, such as low density, biocompatibility, elastic modulus like bone, and high toxicity limits. However, improvements are needed in mechanical properties and degradation rate. This study focuses on enhancing these properties by developing a novel composite of magnesium with carbonate apatite (CA) reinforcement, Mg/5CA. Compared to hydroxyapatite (HA), CA offers better absorption and avoids fibrotic tissue formation. However, CA undergoes carbonate decomposition during sintering, leading to composite degradation. To address this, an extrusion process is employed to prevent carbonate decomposition. The advanced sintering and extrusion compaction processes are compared for the Mg/5CA composite, examining density, microstructure, hardness, compressive strength, and biocorrosion. Results demonstrate that extrusion increases relative density while CA slightly reduces it. Microstructural analysis reveals finer and elongated grains, tighter bonding between CA and Mg particles, and reduced microporosity in the extruded composite. Mechanical properties, including hardness distribution and compressive strength, are improved in the extruded composite, and the degradation rate decreases compared to sintering. Overall, the extrusion process effectively enhances Mg/5CA composite properties, positioning it as a promising manufacturing technique for biodegradable implant materials. This research contributes to the development of advanced biodegradable implants, which can have significant applications in the field of medical science. Further investigations in this area can contribute to the ongoing advancements in biodegradable implant technology.

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“…Additionally, the crystal size is reduced, which in turn, decreases the lattice spacing, [ 46 ] while increasing their relative surface area. [ 47 ] The mechanical changes imparted from these structural differences include improved fracture toughness and diametral tensile strength, [ 47 ] as well as a decrease in the elastic moduli which correlates with increasing carbonate content. [ 46 ] The chemical composition of carbonated apatite is also known to increase from the stoichiometric HA ratio of 1.67 Ca:PO to as high as 2 Ca:PO, [ 44 ] though this varies throughout apatite bulk.…”

Section: Introductionmentioning

confidence: 99%

Advances in biomimetic collagen mineralisation and future approaches to bone tissue engineering

et al. 2022

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Effect of Carbonate Contents on the Thermal Stability and Mechanical Properties of Carbonated Apatite Artificial Bone Substitute

Cited by 8 publications

References 48 publications

Towards Polycaprolactone-Based Scaffolds for Alveolar Bone Tissue Engineering: A Biomimetic Approach in a 3D Printing Technique

Towards Polycaprolactone-Based Scaffolds for Alveolar Bone Tissue Engineering: A Biomimetic Approach in a 3D Printing Technique

Composite of Magnesium and Carbonate Apatite for Biodegradable Bone Implants: A Comparative Study on Sintering and Extrusion Techniques

Advances in biomimetic collagen mineralisation and future approaches to bone tissue engineering

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