Effect of carbonization degree of carbon dots on cytotoxicity and photo-induced toxicity to cells

Esfandiari, Neda; Bagheri, Zeinab; Ehtesabi, Hamide; Fatahi, Zahra; Tavana, Hossein; Latifi, Hamid

doi:10.1016/j.heliyon.2019.e02940

Cited by 61 publications

(30 citation statements)

References 48 publications

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“…In contrast, polyethyleneimine-coated dots can enter the nucleus and cause severe toxicity at lower concentrations (100 μg/ml) (Havrdova et al, 2016). Effect of carbonization degree of CDs on cytotoxicity and photoinduced toxicity was observed in cells (Esfandiari et al, 2019). Negative-charged CDs (fabricated at 160°C for 50 min) with smaller than 5 nm showed a significantly higher quantum yield.…”

Section: Toxicitymentioning

confidence: 98%

Drug Delivery With Carbon-Based Nanomaterials as Versatile Nanocarriers: Progress and Prospects

Debnath

Srivastava

2021

Front. Nanotechnol.

135

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With growing interest, a large number of researches have been conducted on carbon-based nanomaterials (CBNs). However, their uses are limited due to comprehensive potential environmental and human health effects. It is often confusing for researchers to make an informed choice regarding the versatile carbon-based nanocarrier system and its potential applications. This review has highlighted emerging applications and cutting-edge progress of CBNs in drug delivery. Some critical factors like enzymatic degradation, surface modification, biological interactions, and bio-corona have been discussed here. These factors will help to fabricate CBNs for effective drug delivery. This review also addresses recent advancements in carbon-based target specific and release controlled drug delivery to improve disease treatment. The scientific community has turned their research efforts into the development of novel production methods of CBNs to make their production more attractive to the industrial sector. Due to the nanosize and diversified physical properties, these CBNs have demonstrated distinct biological interaction. Thus long-term preclinical toxicity study is recommended before finally translating to clinical application.

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Section: Toxicitymentioning

confidence: 98%

Drug Delivery With Carbon-Based Nanomaterials as Versatile Nanocarriers: Progress and Prospects

Debnath

Srivastava

2021

Front. Nanotechnol.

135

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“…Some diagnostic and imaging agents, such as carbon dots, can be utilized for cancer detection and imaging in the combination of liposomes or singly [ 46 ]. Although carbon dots are partially approved for clinical application and exploited in investigations, cytotoxicity remains a challenging barrier for their wide application [ 47 ]. The general structure of liposomal drug NPs is shown in Fig.…”

Section: Main Textmentioning

confidence: 99%

Liposomal Nanomedicine: Applications for Drug Delivery in Cancer Therapy

2021

Self Cite

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The increasing prevalence of cancer, a disease in which rapid and uncontrollable cell growth causes complication and tissue dysfunction, is one of the serious and tense concerns of scientists and physicians. Nowadays, cancer diagnosis and especially its effective treatment have been considered as one of the biggest challenges in health and medicine in the last century. Despite significant advances in drug discovery and delivery, their many adverse effects and inadequate specificity and sensitivity, which usually cause damage to healthy tissues and organs, have been great barriers in using them. Limitation in the duration and amount of these therapeutic agents’ administration is also challenging. On the other hand, the incidence of tumor cells that are resistant to typical methods of cancer treatment, such as chemotherapy and radiotherapy, highlights the intense need for innovation, improvement, and development in antitumor drug properties. Liposomes have been suggested as a suitable candidate for drug delivery and cancer treatment in nanomedicine due to their ability to store drugs with different physical and chemical characteristics. Moreover, the high flexibility and potential of liposome structure for chemical modification by conjugating various polymers, ligands, and molecules is a significant pro for liposomes not only to enhance their pharmacological merits but also to improve the effectiveness of anticancer drugs. Liposomes can increase the sensitivity, specificity, and durability of these anti-malignant cell agents in the body and provide remarkable benefits to be applied in nanomedicines. We reviewed the discovery and development of liposomes focusing on their clinical applications to treat diverse sorts of cancers and diseases. How the properties of liposomal drugs can be improved and their opportunity and challenges for cancer therapy were also considered and discussed. Graphic abstract

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“…However, the role of the synthesis approach on the toxicity of fabricated CDs has not been fully explored yet [ 56 ]. A study done by Esfandiari et al [ 56 ] studied the effect of carbonization degree in the synthesis of four different CDs on cytotoxicity, photo-induced toxicity, and cellular uptake under different experimental conditions. The authors synthesized CDs via citric acid thermal decomposition at different temperatures and time durations.…”

Section: Properties Of Cdsmentioning

confidence: 99%

“…There are multiple studies on the cytotoxicity of CDs in different concentrations in various cell lines. However, the role of the synthesis approach on the toxicity of fabricated CDs has not been fully explored yet [56]. A study done by Esfandiari et al [56] studied the effect of carbonization degree in the synthesis of four different CDs on cytotoxicity, photo-induced toxicity, and cellular uptake under different experimental conditions.…”

Section: Biocompatibilitymentioning

confidence: 99%

Carbon Dot Nanoparticles: Exploring the Potential Use for Gene Delivery in Ophthalmic Diseases

Biswal

Bhatia

2021

Nanomaterials

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Ocular gene therapy offers significant potential for preventing retinal dystrophy in patients with inherited retinal dystrophies (IRD). Adeno-associated virus (AAV) based gene transfer is the most common and successful gene delivery approach to the eye. These days, many studies are using non-viral nanoparticles (NPs) as an alternative therapeutic option because of their unique properties and biocompatibility. Here, we discuss the potential of carbon dots (CDs), a new type of nanocarrier for gene delivery to the retinal cells. The unique physicochemical properties of CDs (such as optical, electronic, and catalytic) make them suitable for biosensing, imaging, drug, and gene delivery applications. Efficient gene delivery to the retinal cells using CDs depends on various factors, such as photoluminescence, quantum yield, biocompatibility, size, and shape. In this review, we focused on different approaches used to synthesize CDs, classify CDs, various pathways for the intake of gene-loaded carbon nanoparticles inside the cell, and multiple studies that worked on transferring nucleic acid in the eye using CDs.

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Effect of carbonization degree of carbon dots on cytotoxicity and photo-induced toxicity to cells

Cited by 61 publications

References 48 publications

Drug Delivery With Carbon-Based Nanomaterials as Versatile Nanocarriers: Progress and Prospects

Drug Delivery With Carbon-Based Nanomaterials as Versatile Nanocarriers: Progress and Prospects

Liposomal Nanomedicine: Applications for Drug Delivery in Cancer Therapy

Carbon Dot Nanoparticles: Exploring the Potential Use for Gene Delivery in Ophthalmic Diseases

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