Effect of Cardioplegic and Organ Preservation Solutions and Their Components on Coronary Endothelium-Derived Relaxing Factors

Yang, Qin; He, Guo‐Wei

doi:10.1016/j.athoracsur.2004.10.003

Cited by 24 publications

(18 citation statements)

References 120 publications

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“…Recently, they have been used in hyperpolarizing cardioplegia which has a protective role on endothelial function in coronary microcirculation (Yang and He, 2005). Recently, they have been used in hyperpolarizing cardioplegia which has a protective role on endothelial function in coronary microcirculation (Yang and He, 2005).…”

Section: Discussionmentioning

confidence: 99%

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Characteristics of the antivasoconstrictor effect of pinacidil on isolated radial artery

Gojkovic-Bukarica¹,

Stojnic²,

Perić³

et al. 2010

Acta vet. (Beogr.)

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Pinacidil, a prevously studied potassium channel opener (PCO), is a potent antihypertensive agent in animals and humans. Its mechanism of action is not completly defined. The aim of our study was to investigate the antivasoconstricting effect of pinacidil on the isolated RA and to study whether this effect is endothelium-dependent. Contractions of isolated RA rings with intact endothelium were provoked by electrical field stimulation (EFS, 20 Hz) or exogenously applied noradrenaline (NA, 10 μM). Pinacidil (10 nM-0.1 mM) produced a concentration-dependent inhibition of both EFS- and NA-evoked contractions (p>0.05). NO synthesis inhibitor, L-NAME (10 μM) and the guanylate cyclase inhibitor, methylene blue (10 μM) did partly antagonize NA-evoked contractions and were without effect on EFSinduced contractions. Thus, the antivasoconstrictor effect of pinacidil on RA is partly endothelium-dependent and probably mediated via cGMP-dependent NO-pathway

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Section: Discussionmentioning

confidence: 99%

“…Recently they have been used in hyperpolarizing cardioplegia which has a protective role on endothelial function in coronary microcirculation (Yang and He, 2005). PCOs are a class of drugs that has the ability to open K + channels and to produce hyperpolarization and relaxation of vascular smooth muscle cells.…”

Section: Introductionmentioning

confidence: 99%

Characteristics of the antivasoconstrictor effect of pinacidil on isolated radial artery

Gojkovic-Bukarica¹,

Stojnic²,

Perić³

et al. 2010

Acta vet. (Beogr.)

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show abstract

“…The most dangerous outcome of endothelial dysfunction is the no-reflow phenomenon, which frequently leads to cardiac failure. Several studies invoke the involvement of nitric oxide (NO) in the mechanisms related to cardioplegia-reperfusion injury [6], since both coronary and myocardial functions are widely affected by NO signaling and regulation [7]. Moreover, deregulation of NO metabolism can provoke damages at several levels, such as decrease in oxygen consumption, reduction in the antioxidant potential, alterations of both platelet and leukocyte functions, and unpaired ventricular relaxation, which ultimately negatively affect myocardial contractility [8].…”

Section: Introductionmentioning

confidence: 99%

Leupeptin Preserves Cardiac Nitric Oxide Synthase 3 During Reperfusion Following Long-Term Cardioplegia

Muscari

Capanni²,

Giordano

et al. 2010

Journal of Surgical Research

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“…HTK solution is less effective because its composition is poor in these agents (Belzer & Southard 1988). Yang and He (2005) reviewed the data related to the use of preservation solutions in cardiac transplantation. The authors noted that UW was an effective tissue protector in heart transplantation (Swanson et al 1988), but less effective in abdominal-tissue transplantation.…”

Section: Preservation Solutionsmentioning

confidence: 99%

Potential benefits of melatonin in organ transplantation: a review

Esteban‐Zubero

García-Gil

López-Pingarrón

et al. 2016

Journal of Endocrinology

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Organ transplantation is a useful therapeutic tool for patients with end-stage organ failure; however, graft rejection is a major obstacle in terms of a successful treatment. Rejection is usually a consequence of a complex immunological and nonimmunological antigen-independent cascade of events, including free radical-mediated ischemia-reperfusion injury (IRI). To reduce the frequency of this outcome, continuing improvements in the efficacy of antirejection drugs are a top priority to enhance the long-term survival of transplant recipients. Melatonin (N-acetyl-5-methoxytryptamine) is a powerful antioxidant and ant-inflammatory agent synthesized from the essential amino acidl-tryptophan; it is produced by the pineal gland as well as by many other organs including ovary, testes, bone marrow, gut, placenta, and liver. Melatonin has proven to be a potentially useful therapeutic tool in the reduction of graft rejection. Its benefits are based on its direct actions as a free radical scavenger as well as its indirect antioxidative actions in the stimulation of the cellular antioxidant defense system. Moreover, it has significant anti-inflammatory activity. Melatonin has been found to improve the beneficial effects of preservation fluids when they are enriched with the indoleamine. This article reviews the experimental evidence that melatonin is useful in reducing graft failure, especially in cardiac, bone, otolaryngology, ovarian, testicular, lung, pancreas, kidney, and liver transplantation.

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Effect of Cardioplegic and Organ Preservation Solutions and Their Components on Coronary Endothelium-Derived Relaxing Factors

Cited by 24 publications

References 120 publications

Characteristics of the antivasoconstrictor effect of pinacidil on isolated radial artery

Characteristics of the antivasoconstrictor effect of pinacidil on isolated radial artery

Leupeptin Preserves Cardiac Nitric Oxide Synthase 3 During Reperfusion Following Long-Term Cardioplegia

Potential benefits of melatonin in organ transplantation: a review

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