2009
DOI: 10.1590/s0100-879x2009000600016
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Effect of cardiopulmonary bypass on the pharmacokinetics of propranolol and atenolol

Abstract: The pharmacokinetics of some β-blockers are altered by cardiopulmonary bypass (CPB). The objective of this study was to compare the effect of coronary artery bypass graft (CABG) surgery employing CPB on the pharmacokinetics of propranolol and atenolol. We studied patients receiving oral propranolol with doses ranging from 80 to 240 mg (N = 11) or atenolol with doses ranging from 25 to 100 mg (N = 8) in the pre-and postoperative period of CABG with moderately hypothermic CPB (32°C). On the day before and on the… Show more

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