Effect of cardiotoxic doses of adrenergic amines on myocardial cyclic AMP

Blaiklock, Robert G.; Hirsh, Eva M.; Lehr, David

doi:10.1016/0022-2828(78)90370-x

Cited by 13 publications

(1 citation statement)

References 20 publications

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“…Since both hypertensive manoeuvres were effective in generating ventricular arrhythmias we elected the latter, for practical reasons. Although it has been demonstrated that phenylephrine can produce an increase in myocardial cyclic AMP in vitro, this effect has not been shown in the intact 6 animal. Therefore we do not think that the arrhythmias precipitated by this presser agent were secondary to its cellular effects.…”

Section: Discussionmentioning

confidence: 92%

The antiarrhythmic effects of verapamil and propranolol in aminophylline toxic dogs

Friesen

Bonet

1983

Can Anaesth Soc J

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Potentially lethal cardiac arrhythmias are a cardiovascular complication of severe aminophylline toxicity, i Despite the serious implications of these rhythm disturbances, little clinical and experimental information concerning the rational pharmacologic approach to this problem is available. Furthermore, much of the knowledge encompassing the medical management of arrhythmias was obtained from numerous experimental and clinical models which might not reproduce the electrical behaviour of the aminophylline toxic heart and thus are not totally applicable to this problem. 2 Moreover, the multiple cardiovascular and systemic effects of aminophylline secondary to phosphodiesterase inhibition, stimulation of catecholamine synthesis and release as well as altered intra-cellular calcium kinetics s can severely limit the usefulness of many antiarrhythmie agents.In an effort to better understand these arrhythmias and to provide a more rational approach to their pharmacologic management, we independently investigated the calcium channel blocker verapamil and the beta adrenoreeeptor blocker propranolol in aminophylline toxic dogs. MethodsEighteen dogs were intubated and ventilated after induction of anaesthesia (pentobarbitone 30 mg/kg CAN ANAESTH sac J 1983 / 30:2 / pp 124-131

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Section: Discussionmentioning

confidence: 92%