Effect of Careya arborea Roxb. on CCl4 induced liver damage in rats

Abstract

The aqueous extract of bark of Careya arborea Roxb., locally known as Kumbhi, was screened for hepatoprotective activity against CCl 4 -induced hepatotoxicity in rats with a view to explore its application for treatment of liver disorders in animals and human beings. The hepatotoxicity induced by administration of carbon tetrachloride (CCl 4 ) as 30 % solution prepared in liquid paraffin and administered subcutaneously 1ml/kg b.wt. at every 72 h interval till the completion of experiment. The hepatotoxicity was found to be tolerated by simultaneous oral administration of aqueous extract of C. arborea (AECA) stem bark (100, 200 mg/kg b. wt.) for two weeks, with evidence of decreased level of AST, ALT, ALP and bilirubin. In addition, severe histomorphological disruption and fatty changes produced by CCl 4 in respect of cytoarchitecture were minimized and maintained by the treatment of extract. The results were compared with standard drug silymarine. The results of this study showed that AECA could afford hepatoprotective activity against CCl 4 induced liver damage in rats due to nutraceutical nature of plant.

Medicinal herbs and their metabolites with biological potential to protect and combat liver toxicity and its disorders: A review

“…Used in diarrhea, dysentery with bloody stools and ear pain. [ 74 , 75 ] Carica papaya Linn. ( Carieaceae ) Aqueous extract of Fruits Sprague-Dawley rats Carbon tetrachloride 100 mg/kg AST↓, ALT↓, ALP↓ Antisickling, anthelmintic, anti-diabetic, and anti-cancer [ 76 ] Carthamus tinctorius Linn.…”

Careyarboside A: A New Flavan-3-ol Glycoside from the Stems of Careya arborea (Lecythidaceae)

“…Te dried stem bark of this plant has been widely used as traditional medicine for the treatment of tumors, infammation, epileptic fts, skin disease, dysentery with bloody stools, dyspepsia, ulcer, and chronic ear pain, as well as an anthelmintic, astringent, and antidote to snake venom [1][2][3]. C. arborea has a wide range of pharmacological activities, such as antitumor, antioxidant, antihyperlipidemic, antibacterial, antimicrobial, hepatoprotective, anti-infammation, analgesic, gastroprotective, antiasthmatic, antifertility, and antidiarrheal efects [4][5][6][7][8][9][10][11][12][13][14]. Te pharmacognostical properties are mainly determined by the various natural compounds in C. arborea, such as triterpenoids, phenolics, favonoids, sterols, coumarin, saponins, and tannins [1,[15][16][17][18][19].…”