Effect of Carnitine and herbal mixture extract on obesity induced by high fat diet in rats

Amin, Kamal Adel; Nagy, Mohamed

doi:10.1186/1758-5996-1-17

Cited by 145 publications

(122 citation statements)

References 81 publications

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“…Similar observations were reported in several studies (He et al, 2008;Amin and Nagy, 2009;Koya-Miyata et al, 2009;Lee et al, 2009;Bhalodia et al, 2010;Rachh et al, 2010). Administration of Coenzyme Q10 for last month inhibited the percentage change of body weight in rats treated with high cholesterol diet and con oil.…”

Section: Discussionsupporting

confidence: 77%

Hypolipidemic Effects of Coenzyme Q10 in Experimentally Induced Hypercholesterolemic Model in Female Rats

Al-Attar¹

2010

American Journal of Pharmacology and Toxicology

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Problem statement: Hyperlipidemia is well known to play a main role in the development of atherosclerosis. It is characterized by abnormally elevated cholesterol, triglyceride, low density lipoprotein cholesterol and very low density lipoprotein cholesterol levels in the blood. It has been recognized for many years that hypercholesterolemia is a major risk factor for cardiovascular diseases such as atherosclerosis, myocardial infraction, heart attacks and cerebrovascular diseases. In recent years, Coenzyme Q10 has gained considerable attention as a dietary supplement capable of influencing cellular bioenergetics and as a supplementary treatment for some chronic diseases. Approach: The present study was undertaken to evaluate whether Coenzyme Q10 supplementation would alter high cholesterol dietinduced hypercholesterolemic model in female rats. Sixty female albino rats of the Wistar strain weighing between 34.3 and 42.1 g were used. The experimental animals were divided into six groups. Rats of group 1 served as controls, fed with standard diet and had free access to water for three months. Rats of group 2 were daily supplemented with 1 mL of corn oil containing 10 mg of cholesterol/rat for two months. Animals of group 3 were daily supplemented with 1 mL of corn oil containing 10 mg of cholesterol/rat for two months and daily supplemented with 1 mg Coenzyme Q10/rat at third month. Rats of group 4 were daily supplemented with 1 mL of corn oil /rat for two months. The experimental rats of group 5 were daily supplemented with 1 mL of corn oil /rat for two months and daily supplemented with 1 mg Coenzyme Q10/rat at third month. Rats of group 6 were supplemented with 1 mg Coenzyme Q10/rat at third month. The body weight percentage changes were determined after second and third months in all experimental groups. Results: After 2 months, the maximum changes of body weight were noted in groups treated with high cholesterol diet and corn oil. After three months, the maximum percentage changes were observed in groups two and four and the minimum changes were noted in sixth group supplemented with only Coenzyme Q10 at last period. Serum triglycerides, cholesterol, High Density Lipoprotein Cholesterol (HDL-C), Low Density Lipoprotein Cholesterol (LDL-C), Very Low Density Lipoprotein Cholesterol (VLDL-C), Atehrogenic Index (AI) and HDL Cholesterol (HDL-C) ratio were assessed at the end of experimental period. Significant increases in the levels of triglycerides, cholesterol, LDL-C VLDL-C were noted in rats supplemented with high cholesterol diet, while the level of HDL-C was significantly reduced. Similar observations were noted in rats treated with high cholesterol diet plus Coenzyme Q10. Statistically, the treatment of Coenzyme Q10 in rats subjected to high cholesterol diet showed a decrease in the change levels of these parameters. Also, the Atehrogenic Index (AI) value was significantly elevated in rats supplemented with high cholesterol diet compared with control value. Administration of Coenzyme Q10 for a peri...

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Section: Discussionsupporting

confidence: 77%

Hypolipidemic Effects of Coenzyme Q10 in Experimentally Induced Hypercholesterolemic Model in Female Rats

Al-Attar¹

2010

American Journal of Pharmacology and Toxicology

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“…Furthermore, there was a statistically significant increase (P<0.01) in the plasma glucose level in both the FD group and the FD+TQ group as compared with their control groups respective. The reason for this may be that the high fat diet induced hyperglycemia, hyperinsulinemia and insulin resistance [9] . However, the short experimental period of this study may not have been long enough to observe hyperinsulinemia and insulin resistance.…”

Section: Discussionmentioning

confidence: 99%

“…In this study, however, the numerical increases in body weight were found to be statistically insignificant in the FD group compared to the control group at the end of the 6 th week. Several studies reported that body weights in high fat diet groups were heavier than standard diet groups during 6-12 week periods [9,10] . The reason for this result may be due to the short experimental period of this study.…”

Section: Discussionmentioning

confidence: 99%

“…A high fat diet leads to increases in body weight, mainly due to excessive energy intake compared to a standard diet [9] . In this study, however, the numerical increases in body weight were found to be statistically insignificant in the FD group compared to the control group at the end of the 6 th week.…”

Section: Discussionmentioning

confidence: 99%

“…Carnitine is an important bio-molecule for the transport of long-chain fatty acids from the cytosol into the mitochondria during beta-oxidation [9] . Normal plasma carnitine concentration may be regulated by dietary sources, excretion from the kidney and endogeneous biosynthesis.…”

Section: Discussionmentioning

confidence: 99%

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Effects of Thymoquinone on Plasma Leptin, Insulin, Thyroid Hormones and Lipid Profile in Rats Fed A Fatty Diet

Güllü¹,

Avcı²

2013

Kafkas Univ Vet Fak Derg

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SummaryThe purpose of this study was to investigate the effects of thymoquinone (TQ) on plasma hormone levels, which regulate energy metabolism, and on the lipid profile of rats fed a standard and fatty diets. The study was performed on four experimental groups for 6 weeks using Wistar Albino rats weighing 200-260 g, aged 5-6 months, with 10 rats in each group. 1) The control group: Rats were fed a standard diet and given 1 ml 0.9% saline /kg body weight/day by gastric gavage.2) The TQ group: Rats were fed a standard diet and given 50 mg TQ/kg body weight/day dissolved in 1 ml 0.9% saline, by gastric gavage.3) The fatty diet (FD) group: Rats were fed an experimental diet containing 50% animal fat and given 1 ml 0.9% saline/kg body weight/day by gastric gavage. 4) The FD+TQ group: Rats were fed an experimental diet containing 50% animal fat and given 50 mg TQ/kg body weight/day dissolved in 1 ml 0.9% saline by gastric gavage. At the end of the experimental period, plasma insulin, thyroxine (T 4 ), high-density lipoprotein (HDL) and low-density lipoprotein (LDL) levels were significantly decreased in the TQ group compared with the control group while the plasma glucose level was increased (P<0.01). In the FD group compared to the control group, HDL and carnitine levels were significantly decreased while plasma leptin, glucose, total triiodothyronine (T 3 ), T 4 , free triiodothyronine (FT 3 ), free thyroxine (FT 4 ), trigliseride (TG), LDL and very low-density lipoprotein (VLDL) levels were significantly increased. Compared to the FD group, in particular, leptin, T 3 , FT 4 , TG, LDL and VLDL levels were significantly decreased in the FD+TQ group except for increased glucose. The study concludes that TQ may be a natural source for the provention of the harmful effects of a fatty diet, due to the dropped levels of leptin, TG, LDL, VLDL and could be considered for use in the field of preventive medicine.

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Omega‐3 polyunsaturated fatty acids and proanthocyanidins improve postprandial metabolic flexibility in rat

et al. 2013

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Postprandial lipemia influences the development of atherosclerosis, which itself constitutes a risk factor for the development of cardiovascular diseases. The introduction of bioactive compounds may prevent these deleterious effects. Proanthocyanidins are potent antioxidants that have hypolipidemic properties, while omega-3 polyunsaturated fatty acids (ω3 PUFAs) stimulate fatty acid oxidation and gene expression programs, controlling mitochondrial functions. In this study, we investigated the effects of acute treatment of ω3 PUFAs and proanthocyanidins on the metabolic flexibility and lipid handling profiles in the skeletal muscle and adipose tissue of rats that were raised on diets, high in saturated fatty acids. For this, oil rich in docosahexaenoic (DHA-OR), grape seed proanthocyanidins extract (GSPE), or both substances (GSPE + DHA-OR) were administered with an overload of lard oil to healthy Wistar rats. Our results indicate that the addition of DHA-OR to lard oil increases insulin sensitivity and redirects fatty acids toward skeletal muscle, thereby activating fatty acid oxidation. We also observed an improvement in adipose mitochondrial functionality and uncoupling. In contrast, GSPE lowers lipidemia, prevents muscle reactive oxygen species (ROS) production and damage, furthermore, activates mitochondrial biogenesis and lipogenesis in adipose tissue. The addition of GSPE+DHA-OR to lard resulted in nearly all the effects of DHA-OR and GSPE administered individually, but the combined administration resulted in a more attenuated profile.

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Effect of Carnitine and herbal mixture extract on obesity induced by high fat diet in rats

Abstract: Background: Obesity-associated type 2 diabetes is rapidly increasing throughout the world. It is generally recognized that natural products with a long history of safety can modulate obesity.

Cited by 145 publications

References 81 publications

Hypolipidemic Effects of Coenzyme Q10 in Experimentally Induced Hypercholesterolemic Model in Female Rats

Hypolipidemic Effects of Coenzyme Q10 in Experimentally Induced Hypercholesterolemic Model in Female Rats

Effects of Thymoquinone on Plasma Leptin, Insulin, Thyroid Hormones and Lipid Profile in Rats Fed A Fatty Diet

Omega‐3 polyunsaturated fatty acids and proanthocyanidins improve postprandial metabolic flexibility in rat

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