Effect of carnosine on healing of lung wounds

Perel'man, M I; Kornilova, Z. Kh.; Paukova, V. S.; Boikov, A. K.; Priĭmak, A A; Bulargina, T. V.; Северин, С. Е.; Tikhonova, G. N.

doi:10.1007/bf00839483

Cited by 7 publications

(3 citation statements)

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“…However, the relevance of low shikimic acid levels during influenza infection is still unknown. Carnosine treatment can decrease the mortality on account of H9N2 influenza virus infection, ameliorate pathological lesions in lungs (Xu et al, 2015), and accelerate repair in the injured lung (Perel’man et al, 1989). Increased carnosine levels in the recovery period of the infection alleviates the damage.…”

Section: Discussionmentioning

confidence: 99%

Dynamic Changes in the Microbiome and Mucosal Immune Microenvironment of the Lower Respiratory Tract by Influenza Virus Infection

Deng

Ren

et al. 2019

Front. Microbiol.

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Influenza is a major public health concern, and the high mortality rate is largely attributed to secondary bacterial infections. There are several mechanisms through which the virus increases host susceptibility to bacterial colonization, but the micro-environment in lower respiratory tract (LRT) of host, infected with influenza virus, is unclear. To this end, we analyzed the LRT microbiome, transcriptome of lung and metabolome of bronchoalveolar lavage fluid (BALF) in mice inoculated intra-nasally with H1N1 to simulate human influenza, and we observed significant changes in the composition of microbial community and species diversity in the acute (7 days post inoculation or dpi), convalescent (14 dpi) and the recovery (28 dpi) periods. The dominant bacterial class shifted from Alphaproteobacteria to Gammaproteobacteria and Actinobacteria in the infected mice, with a significant increase in the relative abundance of anaerobes and facultative anaerobes like Streptococcus and Staphylococcus. The dysbiosis in the LRT of infected mice was not normalized even in the recovery phase of the infection. In addition, the infected lung transcriptome showed significant differences in the expression levels of genes associated with bacterial infection and immune responses. Finally, the influenza virus infection also resulted in significant changes in the metabolome of the BALF. These alterations in the microbiome, transcriptome, and metabolome of infected lungs were not only appeared at the acute period, but also observed at the recovery period. Furthermore, the infection of influenza virus induced a long-term effect in LRT micro-environmental homeostasis, which may give a chance for the invasion of potential pathogens.

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Section: Discussionmentioning

confidence: 99%

Dynamic Changes in the Microbiome and Mucosal Immune Microenvironment of the Lower Respiratory Tract by Influenza Virus Infection

Deng

Ren

et al. 2019

Front. Microbiol.

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“…The efficacy of carnosine on wound healing was demonstrated in several animal models. Perel'man et al (296) established that carnosine was able to double the rate of wound reparative processes in the injured lung of guinea pigs, by activating fibroblast proliferation, connective tissue generation, and intracellular regeneration. More recently, carnosine has been shown to accelerate healing of bleomycin-induced and irradiationinduced pulmonary wounds (92,155).…”

Section: H Wound Healingmentioning

confidence: 99%

Physiology and Pathophysiology of Carnosine

Boldyrev

Aldini

Derave

2013

Physiological Reviews

906

1,023

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Carnosine (β-alanyl-l-histidine) was discovered in 1900 as an abundant non-protein nitrogen-containing compound of meat. The dipeptide is not only found in skeletal muscle, but also in other excitable tissues. Most animals, except humans, also possess a methylated variant of carnosine, either anserine or ophidine/balenine, collectively called the histidine-containing dipeptides. This review aims to decipher the physiological roles of carnosine, based on its biochemical properties. The latter include pH-buffering, metal-ion chelation, and antioxidant capacity as well as the capacity to protect against formation of advanced glycation and lipoxidation end-products. For these reasons, the therapeutic potential of carnosine supplementation has been tested in numerous diseases in which ischemic or oxidative stress are involved. For several pathologies, such as diabetes and its complications, ocular disease, aging, and neurological disorders, promising preclinical and clinical results have been obtained. Also the pathophysiological relevance of serum carnosinase, the enzyme actively degrading carnosine into l-histidine and β-alanine, is discussed. The carnosine system has evolved as a pluripotent solution to a number of homeostatic challenges. l-Histidine, and more specifically its imidazole moiety, appears to be the prime bioactive component, whereas β-alanine is mainly regulating the synthesis of the dipeptide. This paper summarizes a century of scientific exploration on the (patho)physiological role of carnosine and related compounds. However, far more experiments in the fields of physiology and related disciplines (biology, pharmacology, genetics, molecular biology, etc.) are required to gain a full understanding of the function and applications of this intriguing molecule.

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“…During subcutaneous injection of 0.5–1.0 mg, high therapeutic effectiveness in treatment of infectious and rheumatic polyarthritis and ulcer of the gastrointestinal tract was obtained [ 33 ]. Later, positive effect of carnosine in healing wounds of lung tissue was shown [ 34 ]. Japanese researchers played a great role in the study of a wound healing effect of carnosine.…”

Section: Clinical Use Of Carnosinementioning

confidence: 99%

Use of Carnosine for Oxidative Stress Reduction in Different Pathologies

Prokopieva

Yarygina

Бохан

et al. 2016

Oxidative Medicine and Cellular Longevity

108

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The main properties and biological effects of the antioxidant carnosine, the natural dipeptide β-alanyl-L-histidine, are considered. Data on the effective use of carnosine in different pathologies are presented. Special attention is paid to issues of use of carnosine in neurologic and mental diseases, in alcoholism as well as in physiological states accompanied by activation of free-radical processes and formation of oxidative stress.

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Effect of carnosine on healing of lung wounds

Cited by 7 publications

References 1 publication

Dynamic Changes in the Microbiome and Mucosal Immune Microenvironment of the Lower Respiratory Tract by Influenza Virus Infection

Dynamic Changes in the Microbiome and Mucosal Immune Microenvironment of the Lower Respiratory Tract by Influenza Virus Infection

Physiology and Pathophysiology of Carnosine

Use of Carnosine for Oxidative Stress Reduction in Different Pathologies

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