Effect of carrot intake on cholesterol metabolism and on antioxidant status in cholesterol-fed rat

Nicolle, Catherine; Cardinault, Nicolas; Aprikian, Olivier; Busserolles, Jérôme; Grolier, Pascal; Rock, Edmond; Demigné, Christian; Mazur, Andrzej; Scalbert, Augustin; Amouroux, Pierre; Rémésy, Christian

doi:10.1007/s00394-003-0419-1

Cited by 100 publications

(61 citation statements)

References 38 publications

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“…This mutagenic effect may be due to the formation of oxidative compounds of lipidperoxid or Heterocyclic Aromatic Amines (HAAs), that have been found to be mutagenic or carcinogenic (Hamilton et al, 1997;Starvic et al, 1997;Raloff, 1999;Coultate, 2009;Bou et al, 2008). Lipidperoxid compounds may be associated with generation of free radicals causing DNA fragmentation or DNA mutation (Lampe, 1999;Coultate, 2009;Nicolle et al, 2003;Bou et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

Tumor Suppressor P53 Gene Mutations Pattern Induced by Repeated Fried Palm Oil in Rats

Hassanin¹,

Hassan²,

Ali³

et al. 2014

American Journal of Animal and Veterinary Sciences

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The present study aimed to examine the presence of p53 gene mutations in white albino rats fed on repeated fried palm oil. Eighteen sexually mature male Albino rats were used throughout the experiment. Rats were divided randomly into three groups, 6 animals each, namely; control group (CO) which orally administered by distilled water (NO) group which fed on basal diet containing fresh pure palm oil (FO) group which fed on the basal diet containing repeated fried palm oil with a dose of 150 mL kg −1 diet. At the end of the experiment, liver samples were taken, kept at -80°C for genetic alteration studies. Results shows the presence of fifty eight base-pair substitutions mutations which include a total of twelve base pair substitutions arose at A:T base pairs, fourteen base pair substitutions arose at G:C base pairs, Eighteen base pair substitutions at T: A base pairs, fourteen base pair substitutions arose at C:G base pairs. Of the fifty eight substitutional mutations recorded, there were thirty one silent (same sense) mutations and twenty seven missense mutations which causing the substitution of amino acids.

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Section: Discussionmentioning

confidence: 99%

Tumor Suppressor P53 Gene Mutations Pattern Induced by Repeated Fried Palm Oil in Rats

Hassanin¹,

Hassan²,

Ali³

et al. 2014

American Journal of Animal and Veterinary Sciences

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show abstract

“…No carotenoids were found in plasma whereas the three carotenoids were detected in the plasma of the rats fed the carrot diet at 125, 41, 43 nmol/l respective concentrations. β-Carotene was also detected in liver and heart [85][86].Antioxidants and antioxidant capacity of seven colored carrots were studied. Antioxidant capacities of the hydrophilic and hydrophobic fractions were determined using the 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) and 2,2'-diphenyl-1-picrylhydrazyl (DPPH) methods.…”

Section: Daucus Carotamentioning

confidence: 99%

Medicinal plants possessed antioxidant and free radical scavenging effects (part 3)- A review

Al-Snafi¹

2017

IOSRPHR

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Abstract:-Antioxidants are substances that remove, prevent or delay oxidative damage to a target molecule. Therefore, an antioxidant may act to control the level of free radicals to counteract oxidative damage. The effects of medicinal plants in prevention and treatment of many diseases have been widely attributed to their antioxidants activities. This review was designed to highlight the antioxidant effects and free radical scavenging activity of medicinal plants as a third part of our previous reviews.

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“…With the exception of a research by Adams et al (2006) with a transgenic mice model, few studies have investigated the effect of plant material on atherosclerosis and oxidative stress in rodents (Nicolle et al, 2003;Nicolle et al, 2004); moreover, these studies were only focused on the effect of vegetables. Golden Syrian hamsters fed a fat rich diet develop dyslipidemia and atherosclerotic plaques, similar in many respects to human atheroma 1 Mineral mixture contained (mg/kg diet): CaHPO4,17,200;KCl,4000;NaCl,4000;MgO,420;MgSO4,2,000;Fe2O3,120;FeSO4.7H2O,200;trace elements,400 (MnSO4.H2O,98;CuSO4.…”

Section: Atherosclerosismentioning

confidence: 99%

Dietary Antioxidants: From Micronutrients and Phytochemicals to Enzymes - Preventive Effects on Early Atherosclerosis and Obesity

Gaillet¹,

La²,

Rouanet³

2012

Oxidative Stress - Environmental Induction and Dietary Antioxidants

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Effect of carrot intake on cholesterol metabolism and on antioxidant status in cholesterol-fed rat

Abstract: Carrot consumption modifies cholesterol absorption and bile acids excretion and increases antioxidant status and these effects could be interesting for cardiovascular protection.

Cited by 100 publications

References 38 publications

Tumor Suppressor P53 Gene Mutations Pattern Induced by Repeated Fried Palm Oil in Rats

Tumor Suppressor P53 Gene Mutations Pattern Induced by Repeated Fried Palm Oil in Rats

Medicinal plants possessed antioxidant and free radical scavenging effects (part 3)- A review

Dietary Antioxidants: From Micronutrients and Phytochemicals to Enzymes - Preventive Effects on Early Atherosclerosis and Obesity

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