Effect of carticaine on the sarcoplasmic reticulum Ca2+-adenosine triphosphatase. II. Cations dependence

Takara, Delia; Sánchez, G.; Toma, Augusto F.; Bonazzola, Patricia; Alonso, Guillermo

doi:10.1007/s00210-005-1061-7

Cited by 7 publications

(7 citation statements)

References 30 publications

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“…Hydrophobic drugs inhibit CaATPase (Sokolove et al, 1986;Michelangeli et al, 1990;MartinezAzorin et al, 1992;Caravaca et al, 1995;Takara et al, 2000Takara et al, , 2005. Here we report that lidocaine and bupivacaine inhibited the CaATPase activity in sarcoplasmic reticulum membranes from masseter and medial pterygoid muscles.…”

Section: Discussionsupporting

confidence: 51%

“…K i values were higher for Ca uptake than for enzymatic activ ity. Here we must consider that CaATPase activity was measured in the presence of calcimycin and calcium uptake in its absence, and that the relative distributions of the intermediate species of the cycle during the steady state of the reactions were different under both conditions (Takara et al, 2005). Because the enzyme undergoes conformational changes along the cycle, one could expect that any inhibitor displays different affinities for the differ ent enzymatic conformations, and therefore, any change in the relative distributions of the conformers must affect the K i (app) of the inhibitor.…”

Section: Discussionmentioning

confidence: 99%

“…Studies on the effects of dental drugs on the CaATPase from masseter and medial pterygoid muscles have not yet been published. Dental local anesthetics have been reported to inhibit the sarcoplasmic reticulum CaATPase from fast muscles (Suko et al, 1976;Wolosker et al, 1992;Takara et al, 2000Takara et al, , 2005.…”

Section: Local Anesthetics Have Myotoxic Effects and Inhibitmentioning

confidence: 99%

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Local Anesthetics Inhibit Ca-ATPase in Masticatory Muscles

2010

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Local anesthetics have myotoxic effects and inhibit Ca-ATPase activity and Ca transport in skeletal muscles. Such effects have not been fully elucidated in masticatory muscles. We tested the hypothesis that local anesthetics increase myoplasmic calcium in masticatory muscles by inhibiting Ca-ATPase at a concentration similar to that of dental cartridges. The effects of lidocaine and bupivacaine on Ca-ATPase from rabbit masseter and medial pterygoid muscles were tested with radioisotopic and colorimetric methods. Bupivacaine had an action similar to that of lidocaine on Ca-ATPase activity, but less effect on calcium transport. The pre-exposure of the membranes to the anesthetics enhanced the Ca-ATPase activity in the absence of calcium ionophore, supporting their permeabilizing effect. The results demonstrate that amide-type anesthetics do not inhibit calcium binding, but do reduce calcium transport and enzyme phosphorylation by ATP, and suggest that the myoplasmic calcium increase induced by lidocaine and bupivacaine might promote masticatory muscle contraction and eventual rigidity.

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Section: Discussionsupporting

confidence: 51%

Section: Discussionmentioning

confidence: 99%

Section: Local Anesthetics Have Myotoxic Effects and Inhibitmentioning

confidence: 99%

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Local Anesthetics Inhibit Ca-ATPase in Masticatory Muscles

2010

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“…37,41,43 A surge in myoblastic apoptosis is the sequela of LA exposure. 1,19e23,25e29 Apoptosis is triggered by increased Back muscles, 37 back leg muscles, 43 breast muscle, 28 C2C12 cell line, 18e23,25,26 oesophageal muscle, 24 extensor digitorum longus muscle, 1,24,35,36 first lumbrical of foot muscle, 27 flexor digitorum brevis muscle, 24 hind leg muscles 15,32,33,42 masseter muscle, 34,37,41 medial pterygoid, 37,38,41 psoas muscle 40 quadriceps muscle, 29 skeletal muscle, 13,30,31 soleus muscle, 1,24 temporalis muscle, 39 tibialis anterior muscle 1 Humans, 13,29 mice, 1,18e26,35,36 quail, 28 rats, 27 pigs, 42 rabbits 15,30e34,37e41,43 Articaine, 38 benzocaine, 32 bupivacaine, 1,13,18e21,23e29,34,35,41e43 bupivacaine S and R enantiomers, 35,36 bupivacaine with caffeine, 1 bupivacaine with dantrolene, 1 bupivacaine with microspheres, 22 carticaine,…”

Section: Myotoxic Damagementioning

confidence: 99%

Local anaesthetic-induced myotoxicity in regional anaesthesia: a systematic review and empirical analysis

Hussain

McCartney

Neal

et al. 2018

British Journal of Anaesthesia

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Recent reports of local-anaesthetic (LA)-induced myotoxicity after peripheral nerve blocks have increased the interest in this less commonly known complication. Basic science evidence investigating LA-induced myotoxicity seems to demonstrate a pattern, but findings from human studies vary. This systematic review summarises the existing myotoxicity evidence and empirically examines its implications. Databases were searched for all in vitro animal and human studies evaluating LA-induced myotoxicity. Studies were stratified by design. Data sought included the model examined, LA used, injury mechanisms, nature of damage, and extent of recovery. For human studies, we also aimed to estimate prevalence and recovery rates. One hundred and fifteen studies, mainly animal and ophthalmic, were included. Myotoxicity risk factors included higher concentrations and prolonged exposure to LA, and use of bupivacaine. Injury mechanisms involved early and late aberrations to cytoplasmic calcium (Ca) homeostasis by the sarcoplasmic reticulum Ca ATPase. Incidence in ophthalmic studies was 0.77% (392 of 50 618). Inflammatory changes within a few days after exposure marked the onset of myotoxicity, and myo-degeneration followed within the first week post-exposure. Time to recovery in human muscles ranged between 4 days to 1 yr. None/partial and complete recovery were observed in 61% and 38% of patients, respectively. Across all experimental models, skeletal muscles exposed to LA consistently display myotoxic effects. Evidence is robust in animal and ophthalmic studies, and displays a concerning signal with continuous adductor canal block use in human case reports. Exploring the clinical prevalence, severity, and risk-reducing strategies of myotoxicity should be prioritised.

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“…The functional aspects of SERCA, such as structure , enzymatic activity, modulation of calcium transport, binding and efflux, and phosphorylation by ATP and inorganic phosphate (Pi) , as well as the effects of different drugs and cations , have been studied in detail in sarcoplasmic reticulum (SR) membranes isolated from fast‐twitch skeletal muscles. However, few authors have reported on SERCA isolated from masticatory muscles .…”

mentioning

confidence: 99%

Expression of sarcoplasmic‐endoplasmic reticulum Ca‐ATPase isoforms in masticatory muscles

Sánchez

Trinks

Richard

et al. 2013

European J Oral Sciences

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The aim of this study was to characterize the sarcoplasmic-endoplasmic reticulum Ca-ATPase (SERCA) isoforms in rabbit masticatory muscles compared with those in fast-twitch muscle. It was hypothesized that combined expression of the SERCA isoforms in fast- and slow-twitch muscles accounts for lower Ca-ATPase activity. SERCA was isolated by differential centrifugation, the isoforms were determined by ELISA, and the activity of each isoform was measured using a colorimetric method. Activity was tested for significance by anova, and the distribution of isoforms was assessed using the chi-square test (P < 0.05) and correlated to SERCA activity using Spearman's rank correlation. SERCA1 was predominant (90.5%) in fast-twitch muscle, whereas a mixture of SERCA isoforms was found in masticatory muscles: 62-78% was SERCA2, 20-37% was SERCA1, and the SERCA3 content was negligible. Depressor muscles showed a significantly higher content (77.8%) of SERCA2, and elevator muscles showed a higher content (35.4%) of SERCA1. Elevator muscles showed higher expression of SERCA2a (58%), and depressor muscles showed higher expression of SERCA2b (20%). The SERCA1 content was mainly SERCA1a and significantly higher for elevator muscles (33%), whereas depressor muscles showed a higher content of SERCA1b (4%). The SERCA1 content of fast-twitch muscle was mainly SERCA1a (88.5%). It is concluded that the mixture of different SERCA isoforms, along with a substantial content of SERCA2b, in masticatory muscles would support lower Ca-ATPase activity and calcium transport.

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Effect of carticaine on the sarcoplasmic reticulum Ca2+-adenosine triphosphatase. II. Cations dependence

Cited by 7 publications

References 30 publications

Local Anesthetics Inhibit Ca-ATPase in Masticatory Muscles

Local Anesthetics Inhibit Ca-ATPase in Masticatory Muscles

Local anaesthetic-induced myotoxicity in regional anaesthesia: a systematic review and empirical analysis

Expression of sarcoplasmic‐endoplasmic reticulum Ca‐ATPase isoforms in masticatory muscles

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