1991
DOI: 10.1254/jjp.55.186
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Effect of carvedilol on venous return: A mechanism of reduction in blood pressure.

Abstract: ABSTRACT-We studied the effect of carvedilol, a ~Q-blocker with a potent a-blocking activity, on venous return in anesthetized dogs. Though 3,ug/kg of carvedilol caused a slight increase in blood pressure and total peripheral resistance, these changes disappeared by further doses of the agent. On the other hand, each dose of carvedilol (3 -100 ,a g/kg) decreased venous return significantly and dose-dependently. These results indicate that the hypotensive effect of carvedilol mainly depends on the decrease in v… Show more

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“…symptoms, [48][49][50] right ventricular remodeling, and improved exercise duration [51]. Combined angiotensin-receptor and neprilysin inhibitors (ARNIs), which have been extensively studied in acquired HF [52] Currently, OHT wait-list mortality or delisting due to worsening clinical status is disproportionately common for ACHD patients listed as status 1A in the United States [61].…”
Section: Accepted Manuscriptmentioning
confidence: 99%
“…symptoms, [48][49][50] right ventricular remodeling, and improved exercise duration [51]. Combined angiotensin-receptor and neprilysin inhibitors (ARNIs), which have been extensively studied in acquired HF [52] Currently, OHT wait-list mortality or delisting due to worsening clinical status is disproportionately common for ACHD patients listed as status 1A in the United States [61].…”
Section: Accepted Manuscriptmentioning
confidence: 99%