Effect of casein genes - beta-LGB, DGAT1, GH, and LHR - on milk production and milk composition traits in crossbred Holsteins

Molee, Amonrat; Poompramun, Chotima; Mernkrathoke, P.

doi:10.4238/2015.march.30.15

Cited by 29 publications

(30 citation statements)

References 33 publications

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“…Metin Kiyici with coauthors (Metin Kiyici et al, 2019) considers GH gene as one of the promising candidates for assessing the potential milk production of dairy cow. In addition, according to Molee with coauthors (Molee et al, 2015), the LGB + GH gene model may be the most suitable for breeding to improve the milk production of cows. Sabour and Lin (Sabour & Lin, 1996), in turn, found that the V allele of the GH gene was preferable in terms of increasing the milk yield obtained from cows.…”

Section: 1discussionmentioning

confidence: 99%

Influence of Csn3, Lgb, Prl, Gh, Tg5 Genes Alleles on Dairy Productivity and Energy Value of Cow's Milk

2019

CRPJFST

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The aim of our research was to study the dependence of Kholmogorsk breed dairy cows' productivity on polymorphism of kappa-casein (CSN3), betalactoglobulin (LGB), prolactin (PRL), somatotropin (GH), thyroglobulin (TG5) genes. It was found that B allele (BB genotype) of PRL gene caused maximum increase in milk production (19.7%). Maximum increase in milk productivity (15.0%, P <0.001), was found at L allele (LL genotype) of GH gene. Significant increases in the presence of A and B alleles with AA (14.3%) and BB (12.7%) genotypes of CSN3 and LGB genes were detected. The maximum increase in fat mass fraction (0.22%) in milk was found at ABL homozygous genotype of PRL gene, while significant increase of fat content was detected at C allele (CC genotype) of TG5 gene (0.15%, P <0.05). The maximum increase of protein mass fraction at B allele (BB genotype) of PRL gene (0.11%) was detected. The maximum increase in milk protein was found at B and L alleles (BB and LL genotypes) of LGB and GH genes (0.06% with P <0.01 and P <0.001, respectively). Analysis of milk energy value showed that A and B alleles and AA (2.80 MJ / kg) and BB (2.80 MJ / kg) genotypes of CSN3 gene and BB genotype of LGB (2, 82 MJ / kg) and PRL genes (2.93 MJ / kg), as well as the T allele and TT genotype for the TG5 gene (3.17 MJ / kg) are associated with this indicator.

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Section: 1discussionmentioning

confidence: 99%

Influence of Csn3, Lgb, Prl, Gh, Tg5 Genes Alleles on Dairy Productivity and Energy Value of Cow's Milk

2019

CRPJFST

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“…Some authors reported the possibility of using milk protein as a polymorphic genetic marker (Eenennaam and Medrano, 1991;Chung et al, 1996;Kaygisiz and Dogan, 1999;Ikonen et al, 1999;Cardak, 2005;Alipanah et al, 2008;Heck et al, 2009;Mohammadi et al, 2013;Djedovic et al, 2015;Dyman et al, 2015). However, these relationships were reported to be non-significant by other researchers (Sekerden et al, 1999;Jusczak et al, 2001;Micinski et al, 2006;Ozdemir and Dogru, 2007;Gurcan, 2011;Dogru, 2015a;Molee et al, 2015).…”

Section: Introductionmentioning

confidence: 90%

“…However, when analyses were performed according to the recessive model, the dairy subgroup AA vs. AB + BB genotype mean difference was found to be statistically significant (P <0.05) and was observed to provide advantages in favor of AA (Table 1). In some individual studies performed previously, it was reported that CSN3 AA and AB genotypes had superiority (Cardak, 2005;Pawelska-Goral et al, 2008;Bartonova et al, 2012;Molee et al, 2015). Some researchers reported that daily milk yield means were not significant among CSN3 genotypes (Dogru, 1994;Ozdemir and Dogru, 2005;Gurcan, 2011).…”

Section: Analysis Of Csn3 Genotypesmentioning

confidence: 97%

“…When using the completely overdominant model, the mean was found to be statistically superior in favor of AB. In individual studies performed, some researchers reported that the daily milk yield means were significant among BLG genotypes (Cardak, 2005;Molee et al, 2015); however, other researchers reported that the mean differences were not significant (Sekerden et al, 1999;Ozdemir and Dogru, 2007).…”

Section: Analysis Of Blg Genotypesmentioning

confidence: 99%

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Relationships between milk protein polymorphisms and production traits in cattle: a systematic review and meta-analysis

et al. 2018

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Abstract. Many researchers who have studied the relationships between milk protein polymorphisms and some yield traits in dairy cattle have reported incompatible results. In this study, in order to examine the overall relationships between milk protein genes known as major genes (CSN1S1, CSN2, CSN3, and BLG) and some yield traits (daily milk yield, lactation milk yield, fat yield, fat content, protein yield, and protein content), a meta-analysis was performed using some genetic models reported in the results of previous studies on cattle. The results suggest that the relationships of major milk protein genes with other factors should be studied using the codominant genetic model in general. Relationships among some CSN3 genotypes and fat yield, fat content, and protein content, and relationships between some BLG genotypes and daily milk yield, fat content, protein yield, and protein content were significant (P<0.05). No significant (P>0.05) relationships were found between these genotypes and other milk production traits. In addition, no significant (P>0.05) relationships between the CSN1S1 and CSN2 genotypes with the milk production traits examined were observed.

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“…Previous studies of Romanian Simmental cattle have suggested an association between LGB genotypes and milk yield [17]. Molee et al (2015) [22] have shown that the specific combination of genotypes at the GH (growth hormone) and LGB loci can affect milk production and protein content and can therefore serve as a useful genetic marker in selection programs for crossbred Holstein cattle. Finally, it was suggested that the LGB gene may also be important in the context of milk processing technology, as particular genotypes are significantly associated with rennet coagulation time in Brown Swiss cows [23].…”

Section: Introductionmentioning

confidence: 99%

Genes encoding equine β-lactoglobulin (LGB1 and LGB2): Polymorphism, expression, and impact on milk composition

et al. 2020

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β-lactoglobulin is one of the most abundant milk whey proteins in many mammal species, including the domestic horse. The aim of this study was to screen for polymorphism in the equine LGB1 and LGB2 gene sequences (all exons, introns, and 5'-flanking region) and to assess potential relationship of particular genotypes with gene expression levels (measured in milk somatic cells) and milk composition traits (protein, fat, lactose, and total β-lactoglobulin content). Direct DNA sequencing analysis was performed for twelve horse breeds: Polish Primitive Horse (PPH), Polish Coldblood Horse (PCH), Polish Warmblood Horse (PWH), Silesian, Hucul, Fjording, Haflinger, Shetland Pony, Welsh Pony, Arabian, Thoroughbred, and Percheron-and revealed the presence of 83 polymorphic sites (47 and 36 for LGB1 and LGB2 genes, respectively), including eight that were previously unknown. Association analysis of the selected polymorphisms, gene expression, and milk composition traits (conducted for the PPH, PCH, and PWH breeds) showed several statistically significant relationships; for example, the two linked LGB1 SNPs (rs1143515669 and rs1144647991) were associated with total milk protein content (p < 0.01). Our study also confirmed that horse breed had significant impact on both gene transcript levels (p < 0.01) and on milk LGB content (p < 0.05), whereas an influence of lactation period was seen only for gene relative mRNA abundances (p < 0.01).

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Effect of casein genes - beta-LGB, DGAT1, GH, and LHR - on milk production and milk composition traits in crossbred Holsteins

Cited by 29 publications

References 33 publications

Influence of Csn3, Lgb, Prl, Gh, Tg5 Genes Alleles on Dairy Productivity and Energy Value of Cow's Milk

Influence of Csn3, Lgb, Prl, Gh, Tg5 Genes Alleles on Dairy Productivity and Energy Value of Cow's Milk

Relationships between milk protein polymorphisms and production traits in cattle: a systematic review and meta-analysis

Genes encoding equine β-lactoglobulin (LGB1 and LGB2): Polymorphism, expression, and impact on milk composition

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