Advancement in technology has brought intense but healthy competition among professional bodies in Nigeria, especially in the field of accounting. This has systematically transformed the accounting process from a traditional analog to a digital system. It is on this note that this study examined how disruptive technology affects the efficacy of accounting practice in Nigeria. This study employed a survey research method with the use of a structured questionnaire distributed among professional bodies in Ekiti, Osun, and Ondo States, South Western Nigeria. Regression analysis of Ordinary Least Squares coupled with correlation analysis were employed. The results revealed that artificial intelligence, blockchain, big data, and the internet of things had a significant positive effect on the controlled variable in Nigeria. The results also revealed that cloud computing had insignificant negative effect on the dependent variable. With the F Statistics (7.113) = 109.747, P = 0.000 < 0.05), the results showed a significantly strong relationship between the controlling and controlled variables. It is, thus, recommended the pivotal need for accounting practitioners to enhance their knowledge of disruptive technologies through training and retraining, and continuous attendance of related workshops organized by the respective professional bodies in Nigeria.