Effect of CBT on Biased Semantic Network in Panic Disorder: A Multicenter fMRI Study Using Semantic Priming

Yang, Yunbo; Lueken, Ulrike; Richter, Jan; Hamm, Alfons O.; Wittmann, André; Konrad, Carsten; Ströhle, Andreas; Pfleiderer, Bettina; Lang, Thomas; Lotze, Martín; Deckert, Jürgen; Arolt, Volker; Wittchen, Hans‐Ulrich; Straube, Benjamin; Kircher, Tilo

doi:10.1176/appi.ajp.2019.19020202

Cited by 21 publications

(18 citation statements)

References 40 publications

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“…The imperatives for further investigations are to find out: when, how, and at what levels of the linguistic hierarchy social influences are observable, and whether social influences can be interactively modulated by multimodal language inputs in a naturalistic setting. Such an extended interactive model will not only provide a more comprehensive framework for empirical testing, but is also beneficial for a better understanding and treatment of social‐communicative dysfunctions across several types of mental disorders (Dawson, Meltzoff, Osterling, Rinaldi, & Brown, 1998; Green, Horan, & Lee, 2015; Suffel, Nagels, Steines, Kircher, & Straube, 2020; Yang et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

Gesture's body orientation modulates the N400 for visual sentences primed by gestures

Luell

Muralikrishnan

et al. 2020

Human Brain Mapping

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Body orientation of gesture entails social‐communicative intention, and may thus influence how gestures are perceived and comprehended together with auditory speech during face‐to‐face communication. To date, despite the emergence of neuroscientific literature on the role of body orientation on hand action perception, limited studies have directly investigated the role of body orientation in the interaction between gesture and language. To address this research question, we carried out an electroencephalography (EEG) experiment presenting to participants (n = 21) videos of frontal and lateral communicative hand gestures of 5 s (e.g., raising a hand), followed by visually presented sentences that are either congruent or incongruent with the gesture (e.g., “the mountain is high/low…”). Participants underwent a semantic probe task, judging whether a target word is related or unrelated to the gesture‐sentence event. EEG results suggest that, during the perception phase of handgestures, while both frontal and lateral gestures elicited a power decrease in both the alpha (8–12 Hz) and the beta (16–24 Hz) bands, lateral versus frontal gestures elicited reduced power decrease in the beta band, source‐located to the medial prefrontal cortex. For sentence comprehension, at the critical word whose meaning is congruent/incongruent with the gesture prime, frontal gestures elicited an N400 effect for gesture‐sentence incongruency. More importantly, this incongruency effect was significantly reduced for lateral gestures. These findings suggest that body orientation plays an important role in gesture perception, and that its inferred social‐communicative intention may influence gesture‐language interaction at semantic level.

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Section: Discussionmentioning

confidence: 99%

Gesture's body orientation modulates the N400 for visual sentences primed by gestures

Luell

Muralikrishnan

et al. 2020

Human Brain Mapping

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“…Memory Representation, Priming, Generalization, and Anxiety Disorders In addition to the amygdala, the anterior cingulate cortex (ACC) is one region involved in associative memory formation, conflict and aversive memory expression, and PTSD and anxiety disorders (34,84,85). A study reported in this issue of the Journal by Yang et al (86) examines both the behavioral and semantic representation, as well as neural activation of the ACC, in panicrelated representations and exposure therapy in panic disorder. From a translational perspective, this work is exciting in a number of ways.…”

Section: New Findings and Potential Translational Relevancementioning

confidence: 99%

Translating Across Circuits and Genetics Toward Progress in Fear- and Anxiety-Related Disorders

Ressler

2020

AJP

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Anxiety and fear-related disorders are common and disabling, and they significantly increase risk for suicide and other causes of morbidity and mortality. However, there is tremendous potential for translational neuroscience to advance our understanding of these disorders, leading to novel and powerful interventions and even to preventing their initial development. This overview examines the general circuits and processes thought to underlie fear and anxiety, along with the promise of translational research. It then examines some of the data-driven "next-generation" approaches that are needed for discovery and understanding but that do not always fit neatly into established models. From one perspective, these disorders offer among the most tractable problems in psychiatry, with a great deal of accumulated understanding, across species, of neurocircuit, behavioral, and, increasingly, genetic mechanisms, of how dysregulation of fear and threat processes contributes to anxiety-related disorders. One example is the progressively sophisticated understanding of how extinction underlies the exposure therapy component of cognitive-behavioral therapy approaches, which are ubiquitously used across anxiety and fear-related disorders. However, it is also critical to examine gaps in our understanding between reasonably well-replicated examples of successful translation, areas of significant deficits in knowledge, and the role of large-scale data-driven approaches in future progress and discovery. Although a tremendous amount of progress is still needed, translational approaches to understanding, treating, and even preventing anxiety and fear-related disorders offer great opportunities for successfully bridging neuroscience discovery to clinical practice.

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“…In line with this, neurobiological candidate endophenotypes of anxiety disorders, to be assessed by family-genetic studies, may inform about the stability of observed alterations and could potentially serve as risk signatures (Bas-Hoogendam et al, 2016;Bas-Hoogendam, Harrewijn, et al, 2018;Bas-Hoogendam, van Steenbergen, van der Wee, & Westenberg, 2020;Bearden & Freimer, 2006;Beauchaine & Constantino, 2017;Glahn et al, 2012;Glahn, Thompson, & Blangero, 2007;Hasler, Drevets, Gould, Gottesman, & Manji, 2006;Lenzenweger, 2013;Miller & Rockstroh, 2013) (Etkin, 2019). Prospectively planned research would ensure that clinical data as well as confounding variables are carefully collated, and longitudinal designs would allow more detailed investigation of the mechanisms underlying anxiety disorders as well as of the impact of interventions (Gloster et al, 2009;Heinig et al, 2017;Månsson et al, 2016;Phan et al, 2013;Schwarzmeier et al, 2019;Steiger et al, 2017;Talati et al, 2015;Yang et al, 2019); cf. the accomplishments by the Alzheimer's Disease Neuroimaging Initiative (ADNI), an ongoing, longitudinal, multicenter study aimed at developing clinical, imaging, genetic, and biochemical biomarkers for the early detection and tracking of Alzheimer's disease using standardized methods (Mueller et al, 2005;Weiner et al, 2013).…”

Section: Some Recommendations For the Field And Perspectives For The Future Of Enigma-anxietymentioning

confidence: 98%

ENIGMA‐anxietyworking group: Rationale for and organization oflarge‐scaleneuroimaging studies of anxiety disorders

Bas-Hoogendam

Groenewold

Aghajani

et al. 2020

Human Brain Mapping

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Effect of CBT on Biased Semantic Network in Panic Disorder: A Multicenter fMRI Study Using Semantic Priming

Cited by 21 publications

References 40 publications

Gesture's body orientation modulates the N400 for visual sentences primed by gestures

Gesture's body orientation modulates the N400 for visual sentences primed by gestures

Translating Across Circuits and Genetics Toward Progress in Fear- and Anxiety-Related Disorders

ENIGMA‐anxietyworking group: Rationale for and organization oflarge‐scaleneuroimaging studies of anxiety disorders

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