Effect of CD4 T-lymphocyte count and human immunodeficiency virus (HIV) infection stage on the prevalence and pattern of rheumatologic disease in HIV-infected patients in Zaria, North-Western Nigeria

Umar, Aishetu; Adelowo, Olufemi; Garko, Sani B

doi:10.4103/ssajm.ssajm_1_18

Cited by 3 publications

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“…Malombe et al 17 and Dotan et al 25 also reported a female‐dominated population of participants in their studies. Several studies evaluating rheumatic disease in HIV found similar results 18,26,27 . The predominance of females among HIV‐positive participants reflects the 2018 national HIV statistics 28 .…”

Section: Discussionmentioning

confidence: 72%

“…39 Umar et al in Zaria also reported an association between levels of CD4 counts, WHO clinical staging of HIV, and rheumatic diseases. 18 In contrast, reports from Dotan et al, 25 Buskila et al, 11 and Malombe et al 17 did not find an association between CD4 count levels, WHO clinical staging of HIV, and FM. Kaddu et al also found no association between CD4 count levels and rheumatic diseases in HIV patients in Malugo.…”

Section: Discussionmentioning

confidence: 88%

“…Several studies evaluating rheumatic disease in HIV found similar results. 18,26,27 The predominance of females among HIV-positive participants reflects the 2018 national HIV statistics. 28 Biologic factors, such as the larger female genital mucosal area, as well as sociocultural and economic risks, all increase female vulnerability to HIV TA B L E 1 Socio-demographic characteristics of the study participants and controls a acquisition.…”

Section: Re Sultsmentioning

confidence: 99%

“…However, FM was not associated with levels of CD4 count and the use of HAART 17 . Umar et al, in a study done in Zaria, Nigeria to assess the frequency of rheumatologic conditions in HIV‐positive individuals, found that FM existed in 0.5% of those evaluated 18 …”

Section: Introductionmentioning

confidence: 99%

“…17 Umar et al, in a study done in Zaria, Nigeria to assess the frequency of rheumatologic conditions in HIV-positive individuals, found that FM existed in 0.5% of those evaluated. 18 Patients with FM usually have impaired physical function and reduced quality of life. About 50% have difficulties with routine daily activities.…”

Section: Introductionmentioning

confidence: 99%

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Fibromyalgia in HIV‐positive patients in Nigeria: A cross‐sectional prospective study

et al. 2021

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Background Fibromyalgia is a chronic pain syndrome of unknown etiology characterized by chronic widespread musculoskeletal pain and tenderness. It affects the quality of life of patients and has been associated with the human immunodeficiency virus (HIV). The study aimed to determine the prevalence of fibromyalgia in HIV‐positive patients and assess the effect of fibromyalgia on their functional status. Methodology This was a cross‐sectional study comprising 160 treatment‐naive HIV‐positive patients and 160 age‐ and sex‐matched HIV‐negative controls. The diagnosis of fibromyalgia was based on the 2011 modification of the 2010 American College of Rheumatology diagnostic criteria by assessing the widespread pain index and symptom severity score. The severity of fibromyalgia was assessed with the revised fibromyalgia impact questionnaire. Results The prevalence of fibromyalgia in HIV‐positive individuals was found to be 10.6%, which was significantly higher compared with controls (3.1%; P = .008). There was no significant association between fibromyalgia and age, gender, or occupation. There was a significant relationship between CD4 count levels (P < .001), WHO clinical stage (P < .001), and fibromyalgia. A statistically significant higher score on the Revised FM Impact Questionnaire was found in HIV‐positive individuals with fibromyalgia (P < .001). Conclusion The study found that HIV‐positive patients had a significantly higher incidence of fibromyalgia than controls and this was related to active indices of HIV disease. Fibromyalgia had a greater clinical impact on HIV patients than in controls. As a result, fibromyalgia should be identified and treated in people living with HIV.

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Section: Discussionmentioning

confidence: 72%

Section: Discussionmentioning

confidence: 88%

Section: Re Sultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Fibromyalgia in HIV‐positive patients in Nigeria: A cross‐sectional prospective study

et al. 2021

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Rheumatic Manifestations in Hiv Patients in Tertiary Hospital

Singh

2022

Global Journal for Research Analysis

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Background: HIV infection is a common disease in India. Rheumatological manifestations ( RM) are very common in HIV infected patients. Rheumatological manifestations are signicant cause of morbidity in these patients. Aim & Objective: To study the clinical spectrum of rheumatic diseases in HIV positive patients and correlate the above with CD4+ counts. Method & Materials: This study was a cross-sectional study carried out in Motilal Nehru Medical College and associated hospitals, Prayagraj. This study was carried out on 104 patients with HIV. After obtaining informed consent, demographic characteristics and details of the diagnosis of HIV will be ascertained. Patients with self-reported history of previous diagnosis of HIV and those on treatment with anti-retroviral agents will be consider to have HIV would need to have further testing of HIV. After this the patients will go through needed investigations to fulll aims and objective of the study. Statistical analysis and interpretation of the data was done by using SPSS Software version 23. Result: This study was carried out on 104 patients with HIV. The mean (SD) of age (Years) of participant in my study was 38.95 (8.93). The maximum number of participants was in age group of 31 -40 years that were 36.5% of total case. The 54.8% of the participants were Male and 45.2% were Female. Patients with rheumatic manifestation, 6 (5.8%) of the participants had Arthritis/Arthralgia and 1 (1.0%) of the participants had Septic Arthritis and 1 (1.0%) of the participants had Osteomyelitis and 1 (1.0%) of the participants had Avascular Necrosis. 0 (0.0%) of the participants had Systemic Lupus Erythematosus and 2 (1.9%) of the participants had Rheumatoid Arthritis and 0 (0.0%) of the participants had Psoriatic Arthritis. Conclusion: The clinical spectrum of rheumatic disease in HIV patients was that, Arthritis/Arthralgia was most common rheumatic manifestation followed by Septic Arthritis and Osteomyelitis. Study showed that with increase in duration of ART regimen the incidence of rheumatic manifestation was decreases.

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Rheumatic Manifestation in Hiv Patient and Effect of Art on It: Single Centred Study

Sachan

Singh

2023

IJAR

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Background HIV (Human Immunodeciency Virus) infection has now become a chronic illness due to antiretroviral therapy (ART). The prevalence of rheumatic manifestations with disease has been gradual rises. Aim and Objective: Aim of this study was to Find the relation between the rheumatic manifestations and ART drug regimens. This was a Material and methods: cross sectional study carried out on 104 patients of either sex with HIV conrm status attending a tertiary care hospital (Motilal Nehru Medical College and associated hospital). During the study period (June 2020 to August 2021) patients were assessed by clinical examination and with relevant laboratory investigation, to diagnose the rheumatological manifestation, & detailed history of ART therapy and duration of ART therapy. Out of 104 HIV patients 54.8% of the participants were male and 45.2% were Result: male most common rheumatic manifestation was arthritis (65.8%). The mean SD of CD4 count in HIV patients with rheumatic manifestation was 283.12(86.46). This was signicantly lower than HIV patients with no rheumatic manifestation, showed that lower CD4 count increase the incidence of Rheumatic manifestation. Rheumatic manifestation was more in those patients who were on longer duration of ART. There was no signicant difference between ZLN group and TLN group in terms of distribution of rheumatic disease.

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Effect of CD4 T-lymphocyte count and human immunodeficiency virus (HIV) infection stage on the prevalence and pattern of rheumatologic disease in HIV-infected patients in Zaria, North-Western Nigeria

Cited by 3 publications

References 0 publications

Fibromyalgia in HIV‐positive patients in Nigeria: A cross‐sectional prospective study

Fibromyalgia in HIV‐positive patients in Nigeria: A cross‐sectional prospective study

Rheumatic Manifestations in Hiv Patients in Tertiary Hospital

Rheumatic Manifestation in Hiv Patient and Effect of Art on It: Single Centred Study

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