Effect of Cedar (<i>Ziziphus spina-christi</i>) topical solution in mild to moderate acne vulgaris: a randomized clinical study

Shakiba, Rasoul; Nilforoushzadeh, Mohammad Ali; Hashem-Dabaghian, Fataneh; Zangii, Bagher Minaii; Ghobadi, Ali; Shirbeigi, Laila; Aliasl, Jale; Shakiba, Mahdad; Ghods, Roshanak

doi:10.1080/09546634.2019.1692125

Cited by 9 publications

(7 citation statements)

References 22 publications

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“…A 50-year-old guy was successfully treated with the leaf extract for rashes ( Table 1 ). When compared with the control group, there was a significant reduction in the growth of the rashes [ 125 ]. There is a growing demand for the discovery of novel antiviral substances.…”

Section: Resultsmentioning

confidence: 99%

Ethnopharmacology, Biological Evaluation, and Chemical Composition of Ziziphus spina-christi (L.) Desf.: A Review

Abdulrahman

Zakariya

Hama

et al. 2022

Advances in Pharmacological and Pharmaceutical Sciences

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Medicinal plants are the primary raw materials used in the production of medicinal products all over the world. As a result, more study on plants with therapeutic potential is required. The tropical tree Ziziphus spina belongs to the Rhamnaceae family. Biological reports and traditional applications including management of diabetes and treatment of malaria, digestive issues, typhoid, liver complaints, weakness, skin infections, urinary disorders, obesity, diarrhoea, and sleeplessness have all been treated with different parts of Z. spina all over the globe. The plant is identified as a rich source of diverse chemical compounds. This study is a comprehensive yet detailed review of Z. spina based on major findings from around the world regarding ethnopharmacology, biological evaluation, and chemical composition. Scopus, Web of Science, BioMed Central, ScienceDirect, PubMed, Springer Link, and Google Scholar were searched to find published articles. From the 186 research articles reviewed, we revealed the leaf extract to be significant against free radicals, microbes, parasites, inflammation-related cases, obesity, and cancer. Chemically, polyphenols/flavonoids were the most reported compounds with a composition of 66 compounds out of the total 193 compounds reported from different parts of the plant. However, the safety and efficacy of Z. spina have not been wholly assessed in humans, and further well-designed clinical trials are needed to corroborate preclinical findings. The mechanism of action of the leaf extract should be examined. The standard dose and safety of the leaf should be established.

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Section: Resultsmentioning

confidence: 99%

Ethnopharmacology, Biological Evaluation, and Chemical Composition of Ziziphus spina-christi (L.) Desf.: A Review

Abdulrahman

Zakariya

Hama

et al. 2022

Advances in Pharmacological and Pharmaceutical Sciences

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“…A signification proportion of patients across the world are turning to TCM as a cost-effective form of treatment [ 12 , 45 ]. Numerous studies have shown the important role of these therapies in the treatment of various diseases [ 53 - 56 ]. In contrast, very few studies have explored the role of TCM, especially PM, in the prevention and treatment of life-threatening diseases that need immediate care [ 40 , 41 ].…”

Section: Discussionmentioning

confidence: 99%

The Role of Bloodletting and Cupping in Severe Acute Urticaria and Angioedema as Skin Emergencies in Persian Medicine

2022

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Objectives Some dermatological diseases can be life-threatening. Urticaria and angioedema are common reasons for patients to seek treatment at an emergency department. Severe, generalized urticaria and angioedema can endanger patients’ lives by involving the airways and causing anaphylactic shock. The humor-based Persian Medicine (PM) concepts of Shara and Mashara , referring to two kinds of skin lesions, have similarities to urticaria and angioedema, respectively. This article aims to provide scientific evidence regarding the application of PM as an early intervention strategy in the emergency management of urticaria and angioedema. Methods This was a narrative review of PM studies identified by searching medical databases using search terms related to these diseases, as well as risk-associated keywords such as “fatal”, “death”, “life-threatening”, “emergency”, “cupping”, and “bloodletting”. Data were then compared, interpreted, and analyzed. Results PM scholars consider the human body as a unified whole and believe in an inner power (Nature) which stems from the body. When the presence of excessive hot substances cause an imbalance of bodily humors, Nature directs their heated vapors sharply toward the skin, thus causing Shara and Mashara . If there is a high risk of inflammation spreading to vital organs under severe conditions, urgent manual interventions are crucial. Conclusion In serious conditions of urticaria and angioedema, Fasd or bloodletting and Hijama can be effective in speeding up the control of lesions and reducing morbidity and mortality. Consequently, the development of integrated Persian and conventional medicines may provide new therapeutic pathways for skin emergencies.

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“…In a randomized, double-blind trial, participants received the topical cedar solution plus clindamycin 1% or topical placebo plus 1% clindamycin solution for six weeks. The results showed that clindamycin 1% plus cedar solution was more effective than 1% clindamycin plus placebo to cure acne vulgaris ( Shakiba et al, 2019 ).…”

Section: Evaluations Of Ziziphus Genus Impact On the Chronic Inflammatory Disease By The Human Clinical Trialsmentioning

confidence: 99%

“… A randomised, double-blind clinical trial. ( Shakiba et al, 2019 ) Seventy-seven patients An oral administration of omeprazole (20 mg) once per day and given WCYT placebo (3.0 g) three times per day for 4 weeks continuously, or the 2) treatment group (TG), who received oral administration of omeprazole (20 mg) placebo once per day and WCYT (3.0 g) three times per day for 4 weeks continuously. Seventy-seven patients 37 in the control group and 40 target group.The therapeutic effect of WCYT on GERD using omeprazole as a PPI for positive control.…”

Section: Evaluations Of Ziziphus Genus Impact On the Chronic Inflammatory Disease By The Human Clinical Trialsmentioning

confidence: 99%

Genus Ziziphus for the treatment of chronic inflammatory diseases

Alsayari

Wahab

2021

Saudi Journal of Biological Sciences

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Effect of Cedar (Ziziphus spina-christi) topical solution in mild to moderate acne vulgaris: a randomized clinical study

Cited by 9 publications

References 22 publications

Ethnopharmacology, Biological Evaluation, and Chemical Composition of Ziziphus spina-christi (L.) Desf.: A Review

Ethnopharmacology, Biological Evaluation, and Chemical Composition of Ziziphus spina-christi (L.) Desf.: A Review

The Role of Bloodletting and Cupping in Severe Acute Urticaria and Angioedema as Skin Emergencies in Persian Medicine

Genus Ziziphus for the treatment of chronic inflammatory diseases

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