2007
DOI: 10.1161/01.res.0000269778.75877.68
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Effect of Cell-Based Intercellular Delivery of Transcription Factor GATA4 on Ischemic Cardiomyopathy

Abstract: Abstract-Recent loss-of-function studies highlight the importance of the transcription factor GATA4 in the myocardial response to injury in the adult heart. However, the potential effects of gain-in-function of GATA4 overexpression, and transcription factors in general, is hindered by the fact that transcription factors are neither secreted nor taken up by cells. Key Words: GATA4 Ⅲ myocardial infarct Ⅲ cell-based gene therapy Ⅲ VP22 Ⅲ intercellular delivery of protein G ATA4 is critical for the viability and h… Show more

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Cited by 61 publications
(41 citation statements)
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“…Five fields in the infarct zone were randomly selected for each sample and measured by an observer blinded to treatment group with ImagePro Plus software (Media Cybernetics) as previously described. 8,21 …”
Section: Percentage Of Cardiac Myosin-positive Area Measurementmentioning
confidence: 99%
“…Five fields in the infarct zone were randomly selected for each sample and measured by an observer blinded to treatment group with ImagePro Plus software (Media Cybernetics) as previously described. 8,21 …”
Section: Percentage Of Cardiac Myosin-positive Area Measurementmentioning
confidence: 99%
“…In this study, we delivered GATA4 to the cardiac myocytes in the infarct border zone 1 month after acute myocardial infarction using a chimeric cell penetrating peptide strategy. 15 The focal delivery of GATA4 to the border zone led to cardiac myocyte hypertrophy of the border zone cardiac myocytes and no change in the vascular density. This local hypertrophy led to an improvement in cardiac strain in the infarct border zone and global remodeling of the heart in the absence of the generation of new contractile tissue.…”
mentioning
confidence: 99%
“…This local hypertrophy led to an improvement in cardiac strain in the infarct border zone and global remodeling of the heart in the absence of the generation of new contractile tissue. 15 This global remodeling led to improved strain in the noninfarct zone, ultimately improving cardiac function in the absence of any evidence of contractile activity in the infarct zone. The preclinical and clinical data to date, including this important study by Tsuji et al, support the concept that further understanding the biology and physiology of the infarct border zone, along with strategies designed to augment its function, is what will ultimately lead to improvement in patient outcomes.…”
mentioning
confidence: 99%
“…Bian and colleagues 16 tested whether delivery of the transcription factor GATA4, in the form of a GATA4:VP22 fusion protein, could reduce regional cardiac dysfunction associated with myocardial infarction in rats (Figure). To ensure long term expression, the authors used liposomal transfection of an expression vector encoding GATA4:VP22 into cultured rat cardiac fibroblasts.…”
mentioning
confidence: 99%
“…(3) CPP fusion protein delivery. Bian and colleagues injected GATA4:VP22 expressing cardiac fibroblasts into 5 sites of the infarct border region, 16 which presumably led to an enduring but heterogeneous supply of GATA4:VP22 (Ͻ1 mm 2 range) and a corresponding variation in cardiac myocyte size. Will this heterogeneity lead to cardiac arrhythmias?…”
mentioning
confidence: 99%