Effect of cell culture system on the production of human viral antigens

Abstract

0.05). The amount of viral antigen production seems to depend not only on cell concentration, but also on other culture factors such as the characteristic of the cell-growth surface. Thus, the present findings provide a baseline for further improvements and strategies to be established for a scaling-up virus production since depending on the type of virus the optimal conditions found for a small-scale virus production seem unsuitable for large-scale production, requiring new standardization and evaluation.]]>

Propagation and Molecular Characterization of Fowl Adenovirus Serotype 8b Isolates in Chicken Embryo Liver Cells Adapted on Cytodex™ 1 Microcarrier Using Stirred Tank Bioreactor

“…For virus propagation, cells are usually needed, and it is more needed in higher volumes for vaccine production. This is because cell concentration is of significant importance in determining viral titer [38], and viral titer has control on the efficacy of vaccines, which makes the need for a high volume of cells for volume production of vaccine an ongoing requirement.…”