Effect of Cellulose Nanocrystals Content and pH on Swelling Behaviour of Gelatin Based Hydrogel

Yin, Ooi Shok; Ahmad, Ishak; Amin, Mohd Cairul Iqbal Mohd

doi:10.17576/jsm-2015-4406-04

Cited by 41 publications

(6 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a hostile environment (such as enzymes in the stomach or low pH), the protein loaded in the hydrogel is difficult to be damaged, and biomolecules immobilized in hydrogels remains active for a long time [10]. Gelatin hydrogels show favorable biocompatibility in bone tissue engineering and are widely applied in the field of bone cartilage repair [11,12]. But the applications of gelatin hydrogel are limited, due to its poor mechanical properties, rapid degradation rate, rapid drug release, and poor tissue adhesion [13].…”

Section: Introductionmentioning

confidence: 99%

Gelatin-glucosamine hydrochloride/crosslinked-cyclodextrin metal-organic frameworks@IBU composite hydrogel long-term sustained drug delivery system for osteoarthritis treatment

Yang

Kang

et al. 2022

Biomed. Mater.

View full text Add to dashboard Cite

Osteoarthritis is a disease of articular cartilage degradation and inflammation of the joint capsule. Combining anti-inflammatory therapy with nutritional supplement is an effective means for the treatment of osteoarthritis. In this study, we prepared gelatin (Gel) - glucosamine hydrochloride (GH) mixed crosslinked-cyclodextrin metal-organic material (G-GH/CL-CD-MOF) composite hydrogel. Polyethylene glycol diglycidyl ether (PEGDE) was the crosslinking agent of GH and Gel to solve the problem of poor mechanical properties and water solubility at 37 ℃. CL-CD-MOF was fabricated through a simple one-step chemical reaction to crosslink the hydrophilic hydroxyl groups in CD-MOF with diphenyl carbonate (DPC). Electron microscopy and X-ray diffraction analysis of CL-CD-MOF showed perfect porous morphology with a chaotic internal structure. CL-CD-MOF@IBU was prepared by immersing CL-CD-MOF in high-concentration ibuprofen (IBU) solution. CL-CD-MOF@IBU was uniformly dispersed in Gel and GH mixed solution to prepare G-GH/CL-CD-MOF@IBU composite hydrogel long-term sustained drug delivery system. The compression curve of G-GH/CL-CD-MOF composite hydrogel showed a non-linear elastic behavior. The cyclic loading-unloading compression showed that the shape of the G-GH/CL-CD-MOF composite hydrogel can be kept intact under 50% strain. On the day 14, the G-GH/CL-CD-MOF@IBU composite hydrogel was degraded by 87.1%, 61% of IBU was released. G-GH/CL-CD-MOF@IBU exhibited good biocompatibility during co-culture with MC3T3-E1 cells. Briefly, the certain mechanical properties, sustained drug release behavior, and good biocompatibility of G-GH/CL-CD-MOF@IBU composite hydrogel showed that it has potential application in osteoarthritis treatment of long-term sustained nutritional supplement and anti-inflammatory synchronously.

show abstract

Section: Introductionmentioning

confidence: 99%

Gelatin-glucosamine hydrochloride/crosslinked-cyclodextrin metal-organic frameworks@IBU composite hydrogel long-term sustained drug delivery system for osteoarthritis treatment

Yang

Kang

et al. 2022

Biomed. Mater.

View full text Add to dashboard Cite

show abstract

“…The hydrogels were developed following the procedure reported by [31], with some modifications. Table 1 shows the experimental design for obtaining hydrogels, expressed in mass fractions.…”

Section: Hydrogel Developmentmentioning

confidence: 99%

Gelatin-Based Hydrogels Containing Microcrystalline and Nanocrystalline Cellulose as Moisture Absorbers for Food Packaging Applications

Acevedo-Puello,

Figueroa-López,

Ortega-Toro

2023

J. Compos. Sci.

View full text Add to dashboard Cite

Sustainable hydrogels are an innovative biodegradable alternative to traditional packaging materials. They offer exceptional water absorption capacity and high biocompatibility, making them ideal food absorbents to reduce plastic waste, extend shelf life and ensure the safety and quality of packaged foods. In this study, hydrogels based on gelatin, microcrystalline cellulose (MCC), and nanocrystalline cellulose (NCC) were developed, characterized, and applied in the packaging of chicken breasts. For this, MCC was isolated from the banana pseudostem and commercial NCC was incorporated into a gelatin solution to produce the hydrogel materials by film casting. The resulting hydrogels were analyzed in terms of morphology, structural properties, water absorption capacity, mechanical strength, and color properties. The results showed that the incorporation of MCC and NCC significantly improved the mechanical integrity of the hydrogels, which prevented premature deformation of the hydrogels when they absorbed moisture. In addition, changes in the color properties of chicken breast samples in contact with the hydrogels were observed, indicating their ability to preserve food quality. Subsequently, the effectiveness of the hydrogels for chicken breast storage at 4 °C for 4 days was validated. The results demonstrated that the hydrogels developed in this study are a sustainable and environmentally friendly alternative to traditional packaging materials that can extend the shelf life of food products while maintaining their physical and microbiological integrity.

show abstract

“…The use of hydrogels as biomaterials is strongly related to their properties. Hydrogels are three-dimensional network colloidal gels from hydrophilic polymer crosslinked able by swelling to absorb and retain large volumes of water in an aqueous environment [ 18 , 19 , 20 , 21 , 22 , 23 ]. In the swollen state, they have a soft and rubbery structure that mimics the behavior of extracellular matrix (ECM) in biological tissues [ 24 ].…”

Section: Advanced Functional Materials Based On Nanocellulose—general Characteristicsmentioning

confidence: 99%

“…Hydrogels of gelatin (GA), hyaluronic acid (HA), and cellulose nanocrystals (CNC) (GA-HA-CNC) were prepared by freeze-drying method and tested regarding the capacity to promote the attachment, growth, and proliferation of fibroblasts. The three components with different characteristics will have consequently different functions: GA provides a similar extracellular matrix environment for cells to adhere, grow and proliferate [ 23 , 139 ]; HA, with high water-binding properties, participates in tissue hydration and promotes trackless wound healing [ 152 , 153 ]; CNC serve as reinforcing material, significantly enhancing the property of the hydrogels and playing a vital role in the rheology and swelling results. The GA-HA-CNC hydrogels have a smooth surface with a pore size of 80–120 μm, which can provide sufficient volume and surface for cell growth.…”

Section: Nanocellulose-based Materials In Pharmaceutical/medical Applicationsmentioning

confidence: 99%

Advanced Functional Materials Based on Nanocellulose for Pharmaceutical/Medical Applications

Nicu¹,

Ciolacu

Ciolacu³

2021

Pharmaceutics

View full text Add to dashboard Cite

Nanocelluloses (NCs), with their remarkable characteristics, have proven to be one of the most promising “green” materials of our times and have received special attention from researchers in nanomaterials. A diversity of new functional materials with a wide range of biomedical applications has been designed based on the most desirable properties of NCs, such as biocompatibility, biodegradability, and their special physicochemical properties. In this context and under the pressure of rapid development of this field, it is imperative to synthesize the successes and the new requirements in a comprehensive review. The first part of this work provides a brief review of the characteristics of the NCs (cellulose nanocrystals—CNC, cellulose nanofibrils—CNF, and bacterial nanocellulose—BNC), as well as of the main functional materials based on NCs (hydrogels, nanogels, and nanocomposites). The second part presents an extensive review of research over the past five years on promising pharmaceutical and medical applications of nanocellulose-based materials, which have been discussed in three important areas: drug-delivery systems, materials for wound-healing applications, as well as tissue engineering. Finally, an in-depth assessment of the in vitro and in vivo cytotoxicity of NCs-based materials, as well as the challenges related to their biodegradability, is performed.

show abstract

Effect of Cellulose Nanocrystals Content and pH on Swelling Behaviour of Gelatin Based Hydrogel

Abstract: In this research, a novel method was performed to obtain hydrogel with superior thermal stability by incorporation of cellulose nanocrystals (CNC)

Cited by 41 publications

References 49 publications

Gelatin-glucosamine hydrochloride/crosslinked-cyclodextrin metal-organic frameworks@IBU composite hydrogel long-term sustained drug delivery system for osteoarthritis treatment

Gelatin-glucosamine hydrochloride/crosslinked-cyclodextrin metal-organic frameworks@IBU composite hydrogel long-term sustained drug delivery system for osteoarthritis treatment

Gelatin-Based Hydrogels Containing Microcrystalline and Nanocrystalline Cellulose as Moisture Absorbers for Food Packaging Applications

Advanced Functional Materials Based on Nanocellulose for Pharmaceutical/Medical Applications

Contact Info

Product

Resources

About