Effect of cellulose, pectin and chromium(III) on lipid and carbohydrate metabolism in rats

Krzysik, Monika; Grajeta, Halina; Prescha, Anna; Weber, R.

doi:10.1016/j.jtemb.2011.01.003

Cited by 36 publications

(27 citation statements)

References 44 publications

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“…The same authors in another study on rats have shown that the administration of diets containing 5% apple pectin and 10% high polyphenol freeze--dried apples effectively lowered circulating cholesterol and triglyceride concentrations [Aprikian et al, 2003]. Moreover, Krzysik et al [2011] in the study on rats demonstrated that 5% content of pectins in the diet signifi cantly reduced plasma total cholesterol level. In the present study, the dietary addition of apple fi bre preparation unfavourably decreased the proportion of HDL cholesterol in the blood.…”

Section: Discussionmentioning

confidence: 90%

Effects of Dietary Addition of a Low-Pectin Apple Fibre Preparation on Rats

Fotschki

Jurgoński

Juśkiewicz

et al. 2014

Pol. J. Food Nutr. Sci.

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Key words: dietary fi bre, pectins, high-fructose diet, gut metabolism, glycaemia, blood lipidsThe aim of this study was to scrutinise if the dietary addition of a low-pectin fi bre preparation obtained from apple pomace, the by-product of apple concentrate processing, is able to favourably affect the gut metabolism, antioxidant status and blood bio-markers of the organism, as it takes place when apple fi bre is present in the diet as an unprocessed ingredient. The nutritional experiment was performed on rats allocated to 2 groups of 10 animals each and fed for 2 weeks with either a control cellulose-containing diet or an experimental low-pectin apple fi bre-containing diet. To induce metabolic disorders a diet rich in saturated fat and fructose was used in both diet-specifi c groups. The dietary apple fi bre preparation (AFP) significantly reduced the activity of sucrase and maltase in the mucosa of the small intestine. In the caecal digesta, the dietary AFP signifi cantly increased bacterial -glucosidase and -galactosidase activity, whereas bacterial -glucuronidase activity was signifi cantly reduced. Also, the content of short chain fatty acids in the caecal digesta was signifi cantly increased after the AFP supplementation. In the blood serum, the dietary AFP signifi cantly reduced the glucose concentration, and decreased the ratio of total cholesterol to HDL cholesterol. In conclusion, the tested dietary AFP is still able to favourably affect the gut metabolism and can also ameliorate blood glucose concentration, which seems to be related to the inhibition of mucosal disaccharidase activities. However, the analysed preparation has no infl uence on the antioxidant status of the organism and may trigger adverse effects on cholesterol metabolism.

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Section: Discussionmentioning

confidence: 90%

Effects of Dietary Addition of a Low-Pectin Apple Fibre Preparation on Rats

Fotschki

Jurgoński

Juśkiewicz

et al. 2014

Pol. J. Food Nutr. Sci.

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“…Pectin lowers blood and liver cholesterol in various animals, including guinea pigs (Gorinstein et al, 2005), rats (Krzysik et al, 2011), hamsters (Terpstra et al, 2002), chickens (Craig et al, 2006) and rabbits (Ismail et al, 1999). Based on results from several animal studies (Yamaguchi et al, 1995;Trautwein et al, 1998;Dongowski and Lorenz, 2004), it has been stated that the molecular composition of pectin affected cholesterol reductions in blood and liver.…”

Section: Pectin Lowers Cholesterol In Animal Modelsmentioning

confidence: 99%

Cholesterol-lowering properties of different pectin types in mildly hyper-cholesterolemic men and women

et al. 2011

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Background/Objectives: Viscous fibers typically reduce total cholesterol (TC) by 3-7% in humans. The cholesterol-lowering properties of the viscous fiber pectin may depend on its physico-chemical properties (viscosity, molecular weight (MW) and degree of esterification (DE)), but these are not typically described in publications, nor required by European Food Safety Authority (EFSA) with respect to its generic pectin cholesterol-lowering claim. Subjects/Methods: Here, different sources and types of well-characterized pectin were evaluated in humans. Cross-over studies were completed in mildly hyper-cholesterolemic persons receiving either 15 g/day pectin or cellulose with food for 4 weeks. Results: Relative low-density lipoprotein (LDL) cholesterol (LDL-C) lowering was as follows: citrus pectin DE-70 ¼ apple pectin DE-70 (7-10% reduction versus control)4apple pectin DE-35 ¼ citrus pectin DE-354OPF (orange pulp fiber) DE-70 and low-MW pectin DE-704citrus DE-0. In a subsequent 3-week trial with 6 g/day pectin, citrus DE-70 and high MW pectin DE-70 reduced LDL-C 6-7% versus control (without changes in TC). In both studies, high DE and high MW were important for cholesterol lowering. Source may also be important as citrus and apple DE-70 pectin were more effective than OPF DE-70 pectin. Pectin did not affect inflammatory markers high-sensitivity C-reactive protein (hsCRP) nor plasma homocysteine. Conclusions: Pectin source and type (DE and MW) affect cholesterol lowering. The EFSA pectin cholesterol-lowering claim should require a minimum level of characterization, including DE and MW.

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“…Also, there is a report indicating that TG and cholesterol decreased for type 2 diabetic rats following a glasswort diet [9]. Similarly, study results showing that the concentration of TG in the liver and blood was significantly lowered among groups with high-sucrose intake group when water-soluble dietary fiber is added to the diet [23] and also that insoluble dietary fiber reduces the concentration of TG and cholesterol in the liver [17] highlighted the effects of dietary fiber. These results suggest that dietary fiber increases the activity of HMG-CoA reductase in the liver promoting the excretion of fat through increased synthesis of the bile and that it inhibits the synthesis of TG reducing the concentration of cholesterol and TG in blood [10].…”

Section: Discussionmentioning

confidence: 75%

Glasswort Powder Diet Activates Lipid Metabolism in Rat

Seo¹,

Kwak²,

Nam³

et al. 2012

Journal of Life Science

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The purpose of this study was to investigate the effects of glasswort powder intake on lipid metabolism. Rats were divided into three groups: a group fed a normal diet (CON), one fed a high fat diet (HFC), and one fed a high fat diet with glasswort powder (HFG). They were fed their respective diet for four weeks. Body weight was significantly lower (9%) in the HFG group than in the HFC group at the fourth week. According to the feces analysis, the HFG group showed the highest fat level (120% vs. CON; 138% vs. HFC) and fecal calories (110%). The concentration level of TG and LDL-C was 71.8% lower in the HFG group compared to the HFC group, while the concentration level of HDL-C was 152% higher in the HFG group. Expression of FABP in the liver was 197% greater in the HFG compared to the HFC group, with the expression of CPT-1 showing a similar tendency. These results suggest that glasswort powder intake suppresses weight gain and improves fat metabolism at the level of liver cells. From these results, we suggest that glasswort powder is effective against obesity by inhibiting the absorption of fat in the digestive tract.

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Effect of cellulose, pectin and chromium(III) on lipid and carbohydrate metabolism in rats

Cited by 36 publications

References 44 publications

Effects of Dietary Addition of a Low-Pectin Apple Fibre Preparation on Rats

Effects of Dietary Addition of a Low-Pectin Apple Fibre Preparation on Rats

Cholesterol-lowering properties of different pectin types in mildly hyper-cholesterolemic men and women

Glasswort Powder Diet Activates Lipid Metabolism in Rat

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