Effect of central muscarinic receptors on passive-avoidance learning deficits induced by prenatal pentylenetetrazol kindling in male offspring

Pourmotabbed, Ali; Mahmoodi, Gelavij; Mahmoodi, Samaneh; Mohammadi-Farani, Ahmad; Nedaei, Seyed Ershad; Pourmotabbed, Tayebeh

doi:10.1016/j.neuroscience.2014.08.028

Cited by 6 publications

(3 citation statements)

References 51 publications

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“…The rats were randomly divided into control,kindling, and treatment groups (6 groups of 8 rats)and treated for 28 days: [15].Seizure activity was observed for 45. The rats reaching phase 4 or 5were considered kindled rats.…”

Section: Experimental Designmentioning

confidence: 99%

WITHDRAWN: Effects of Satureja Edmondi Briq on Ameliorate Reproductive Parameters in Pentylenetetrazol-Induced Epilepsy Models in Rats

Bohlouli¹,

Mahmoodi²

2020

Preprint

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BackgroundEpilepsy is one of the common neurological brain defects that causes unpredictable, recurrent seizures. It has adverse effects on the reproductive functions.Oxidative stress contributes to the evolution of epilepsy, including reduction of sperm count and motility,increase of abnormal sperm morphology, and low testosterone.Antioxidants are beneficial to spermatogenesis and sperm parameters. Satureja edmondiBriq is known as a powerful antioxidant that can reduce the effects of oxidative stress. The aim of this study was to evaluate the effects of Satureja edmondion reproductive potential in pentylenetetrazol (PTZ)-induced epileptic male rats.MethodsIn this experimental study, 48 Wistar male rats with an average age of 10 weeks and weightof 240- 260g were used. Animals were randomized into normal and kindled groups that were treated with different doses of S.edmondi essential oil. Treatment of animals lasted 4 weeks. In the end, testosterone, follicle-stimulating hormone, luteinizing hormone, and sperm parameters were measured according to the World Health Organization (WHO) standards.ResultsThis study showed that all sperm parameters,including sperm count, sperm viability, and progressive sperm motility were increased and testosterone, follicle-stimulating hormone and luteinizing hormone (FSH,LH) changes in the epileptic and normal groups were changed with an increase in the dose of S.edmondi essential oil. ConclutionsThe changes were significant in some parameters. S.edmondi as a good source of antioxidants can improve sperm parameters and reproductive potential in PTZ-induced epileptic male rats.

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Section: Experimental Designmentioning

confidence: 99%

WITHDRAWN: Effects of Satureja Edmondi Briq on Ameliorate Reproductive Parameters in Pentylenetetrazol-Induced Epilepsy Models in Rats

Bohlouli¹,

Mahmoodi²

2020

Preprint

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“…It has been indicated that the thirteen days of gestation is a critical and important time point for the development of the hippocampus ( 25 26 ). Clinical and experimental studies have revealed that seizures during gestation can result in persistent functional abnormalities in offspring ( 6 13 ). Therefore, maternal seizure at this time point has a long-lasting effect on the hippocampal synaptic plasticity which will affect offspring behavioral response patterns.…”

Section: Discussionmentioning

confidence: 99%

“…It is reported that a single episode of a neonatal seizure can cause disturbance in spatial memory as well as impairment of LTP induction in the CA1 region of the hippocampus in adult rats ( 12 ). Our previous studies demonstrated that central muscarinic receptors are involved in spatial memory and passive avoidance learning impairments in adolescent offspring of pentylenetetrazol-kindled pregnant rats ( 13 14 ). However, the effect of maternal seizure on offspring synaptic plasticity and its mechanism has not been studied.…”

Section: Introductionmentioning

confidence: 99%

The effects of kindling during pregnancy on long-term potentiation (LTP) induction and M1 muscarinic acetylcholine receptors in male rat offspring

Moradpour¹,

Pourmotabbed²,

Naghizadeh³

et al. 2023

Research in Pharmaceutical Sciences

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Background and purpose: Neonates of pregnant women with epilepsy may compromise normal neurodevelopment and hippocampal morphology. Memory and learning disorders and a decrease in verbal IQ scores are seen in these children later in life. In the previous study, we suggested that the central muscarinic cholinergic receptors had an important role in learning and memory deficits induced by prenatal pentylenetetrazol-kindling in pups born to kindled mothers. This study aimed to investigate the effects of kindling during pregnancy on long-term potentiation (LTP) induction and the role of M1 muscarinic acetylcholine receptors in the hippocampus of male offspring. Experimental approach: Twenty female Wistar rats were divided into two groups on the 13 th day of their gestation (kindled and control; n = 10). Animals in the first group were kindled by i.p . injections of 25 mg/kg body weight pentylenetetrazol every 15 min until seizures occurred and the control group received normal saline. The effect of maternal seizures and perfusion of specific M1 muscarinic receptors antagonist (telenzepine at doses of 0.01, 0.1, and 1 nmol) on the LTP induction of 80 pups were tested at 12 weeks of age by field potential recordings. Findings/Results: The results of the electrophysiological study revealed that recurrent seizures during pregnancy impaired field excitatory postsynaptic potentials (fEPSP)-LTP induction and normal development of M1 muscarinic receptors in the hippocampus of male offspring. Also, the results demonstrated that maternal seizure did not significantly affect the paired-pulse indexes and population spike-LTP in the hippocampus of male offspring. Conclusion and implications: Our study showed that recurrent seizures during pregnancy cause impaired fEPSP-LTP induction and abnormal development of the M1 muscarinic receptor in the hippocampus.

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Intra-prefrontal cyclosporine potentiates ketamine-induced fear extinction in rats

2021

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Effect of central muscarinic receptors on passive-avoidance learning deficits induced by prenatal pentylenetetrazol kindling in male offspring

Cited by 6 publications

References 51 publications

WITHDRAWN: Effects of Satureja Edmondi Briq on Ameliorate Reproductive Parameters in Pentylenetetrazol-Induced Epilepsy Models in Rats

WITHDRAWN: Effects of Satureja Edmondi Briq on Ameliorate Reproductive Parameters in Pentylenetetrazol-Induced Epilepsy Models in Rats

The effects of kindling during pregnancy on long-term potentiation (LTP) induction and M1 muscarinic acetylcholine receptors in male rat offspring

Intra-prefrontal cyclosporine potentiates ketamine-induced fear extinction in rats

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