Effect of centrally administered opioid receptor agonists on CSF and plasma oxytocin concentrations in dogs

Brown, Dorothy Cimino; Perkowski, Sandra Z.; Shofer, Frances S.; Amico, Janet A.

doi:10.2460/ajvr.2001.62.496

Cited by 4 publications

(2 citation statements)

References 31 publications

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“…In response to i.v. cholecystokinin, oxytocin is released into the blood and in the hypothalamus (79), but several other agents affect release differentially: for instance, in dogs, opioids stimulate peripheral secretion but suppress central secretion (80). Hyperosmotic stimuli increase oxytocin release from both dendrites and nerve terminals in rats, but on different time scales; dendritic release is increased as plasma concentrations fall (2).…”

Section: Central and Peripheral Release Of Oxytocinmentioning

confidence: 99%

Intranasal Oxytocin: Myths and Delusions

Leng

Ludwig

2016

Biological Psychiatry

527

475

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Despite widespread reports that intranasal application of oxytocin has a variety of behavioral effects, very little of the huge amounts applied intranasally appears to reach the cerebrospinal fluid. However, peripheral concentrations are increased to supraphysiologic levels, with likely effects on diverse targets including the gastrointestinal tract, heart, and reproductive tract. The wish to believe in the effectiveness of intranasal oxytocin appears to be widespread and needs to be guarded against with scepticism and rigor. Preregistering trials, declaring primary and secondary outcomes in advance, specifying the statistical methods to be applied, and making all data openly available should minimize problems of publication bias and questionable post hoc analyses. Effects of intranasal oxytocin also need proper dose-response studies, and such studies need to include control subjects for peripheral effects, by administering oxytocin peripherally and by blocking peripheral actions with antagonists. Reports in the literature of oxytocin measurements include many that have been made with discredited methodology. Claims that peripheral measurements of oxytocin reflect central release are questionable at best.

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Section: Central and Peripheral Release Of Oxytocinmentioning

confidence: 99%

Intranasal Oxytocin: Myths and Delusions

Leng

Ludwig

2016

Biological Psychiatry

527

475

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“… Experimental paradigms. These range from the examination of baseline levels of central and peripheral OT [ 13 , 21 ], and levels following some environmental stimulus such as light [ 22 ], and stressors [ 7 , 23 ], to examinations of concentrations after manipulation of OT levels by osmotic stimulation [ 9 ], drug administration [ 24 – 26 ], or the administration of intranasal [ 14 , 27 ] or intraperitoneal [ 27 ] OT. Since the pharmacokinetics of OT seem to exhibit quite complex, time-dependent patterns [ 9 ], there is a possibility that differences in experimental designs account for differences in correlations between studies.…”

Section: Methodsmentioning

confidence: 99%

The relationship between central and peripheral oxytocin concentrations: a systematic review and meta-analysis protocol

et al. 2016

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BackgroundResearch examining the effects of oxytocin (OT) interventions on psychiatric, social-behavioral, and social-cognitive outcomes regularly collect peripheral levels of OT as markers of central bioavailability. Such inferences rest on the assumption that central and peripheral levels of OT are directly associated. However, conflicting evidence from coordinated sampling of central and peripheral OT question the validity of this assumption. The purpose of this meta-analysis is to evaluate the correlation between central and peripheral OT, as well as to account for potential heterogeneity in the literature.Methods/designStudies that report coordinated sampling of central and peripheral OT in humans and animals will be identified. Research investigating concentrations in both basal states and after exogenous administration will be considered. PubMed and Embase databases will be searched, along with citation lists of retrieved articles. Peer-reviewed studies written in English published from 1971 onwards will be included in the meta-analysis. Data will be extracted from eligible studies for a random-effects meta-analysis. For each study, a summary effect size, heterogeneity, risk of bias, publication bias, and the effect of categorical and continuous moderator variables will be determined.DiscussionThis systematic review and meta-analysis will identify and synthesize evidence to determine if there is an association between central and peripheral OT concentrations. If significant associations are observed, evidence would provide a rationale for future research to use peripheral measures as a proxy for central OT concentrations.Systematic review registrationPROSPERO CRD42015027864Electronic supplementary materialThe online version of this article (doi:10.1186/s13643-016-0225-5) contains supplementary material, which is available to authorized users.

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Oxytocin activates calcium signaling in rat sensory neurons through a protein kinase C-dependent mechanism

et al. 2013

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In addition to its well-known effects on parturition and lactation, oxytocin (OT) plays an important role in modulation of pain and nociceptive transmission. But, the mechanism of this effect is unclear. To address the possible role of OT on pain modulation at the peripheral level, the effects of OT on intracellular calcium levels ([Ca(2+)](i)) in rat dorsal root ganglion (DRG) neurons were investigated by using an in vitro calcium imaging system. DRG neurons were grown in primary culture following enzymatic and mechanical dissociation of ganglia from 1- or 2-day-old neonatal Wistar rats. Using the fura-2-based calcium imaging technique, the effects of OT on [Ca(2+)](i) and role of the protein kinase C (PKC)-mediated pathway in OT effect were assessed. OT caused a significant increase in basal levels of [Ca(2+)](i) after application at the doses of 30 nM (n = 34, p < 0.01), 100 nM (n = 41, p < 0.001) and 300 nM (n = 46, p < 0.001). The stimulatory effect of OT (300 nM) on [Ca(2+)](i) was persistent in Ca(2+)-free conditions (n = 56, p < 0.01). Chelerythrine chloride, a PKC inhibitor, significantly reduced the OT-induced increase in [Ca(2+)](i) (n = 28, p < 0.001). We demonstrated that OT activates intracellular calcium signaling in cultured rat primary sensory neurons in a dose- and PKC-dependent mechanism. The finding of the role of OT in peripheral pain modification may serve as a novel target for the development of new pharmacological strategies for the management of pain.

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Effect of centrally administered opioid receptor agonists on CSF and plasma oxytocin concentrations in dogs

Cited by 4 publications

References 31 publications

Intranasal Oxytocin: Myths and Delusions

Intranasal Oxytocin: Myths and Delusions

The relationship between central and peripheral oxytocin concentrations: a systematic review and meta-analysis protocol

Oxytocin activates calcium signaling in rat sensory neurons through a protein kinase C-dependent mechanism

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