Effect of Certain Corticosteroids and of Growth Hormone of Nucleoproteins of Lymph Nodes

Effects of Corticosterone, Hydrocortisone, and Corticotropin on Production of Antibodies in Rabbits

“…The finding that relatively large amounts of corticotropin depress antibody production is consistent with the observations that highly purified corticotropin decreased the ribonucleic acid concentrations of lymph nodes in a manner similar to that of hydrocortisone or cortisone--an effect not produced by corticosterone (7,8). Such observations are best explained by the finding that persistent administration of corticotropin leads to increased production of hydrocortisone by the adrenal gland of the rabbit (10).…”

“…First, hydrocortisone and corticosterone are the predominant steroids secreted by the adrenal cortex in all the animal species thus far studied and these two hormones may occur singly or together; cortisone, on the other hand, is secreted only in trace amounts if at all (5). Second, hydrocortisone and corticosterone, in the same dosages, exert different effects on clinical inflammatory disorders (4,6), on the size and nucleic acid concentrations of lymph nodes (7,8), and on resistance to infections (4,9). The effect of corticosterone is variable but usually negligible, whereas the activity of hydrocortisone is similar to that of cortisone.…”

The Anemia of Liver Disease: Observations on Its Mechanism 1

“…The failure of cortisone to improve the red cell survival in patients J. B. and D. L., and in A. J., who developed an unusual immune process resulting in strikingly short survival of the cells of certain donors without in vitro evidence of incompatibility during the course of her first and subsequent transfusions, is of interest since recent evidence has suggested a non-specific inhibitory influence of adrenocortical hormones upon red cell removal from tissues (44,45). Since all three patients manifested physical signs of excessive adrenocortical effect while on therapy, and since equal and smaller doses of cortisone have been reported to retard the dispersion of intradermally injected red cells (46), it is unlikely that either inefficient conversion of the cortisone to a physiologic substance or inadequate dosage explains the absence of effect of cortisone upon red cell survival in these patients.…”

Initiation of Parturition in the Rabbit by Maternal and Foetal Administration of Cortisol: Effect of Rate and Duration of Administration: Suppression of Delivery by Progesterone

“…For this possibility to exist, the processes initiated by adrenocorticosteroids in the placenta would have to be differentially sensitive to cortisol and corticosterone. Differences have been reported in the effects of cortico¬ sterone and cortisol on lymphoid tissue in the adult rabbit (Kass, Kendrick & Finland, 1952). The high neonatal rabbit cortisol levels may reflect an increased ACTH secretion by the rabbit foetus before delivery.…”