Effect of Certain Drugs on Perfused Human Placenta VI

Ward, Charles O.; Gautieri, Ronald F.

doi:10.1002/jps.2600550505

Cited by 14 publications

(2 citation statements)

References 15 publications

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“…Serotonin has a powerful vasoconstrictor action on the placental and uterine vasculature. It also has a similar contractile effect on the uterine musculature (Ward & Gautieri 1966;Douglas 1975).…”

Section: Discussionmentioning

confidence: 99%

Serotonin in Toxaemia of Pregnancy

Gujrati¹,

Shanker²,

Parmar³

et al. 1985

Clin Exp Pharma Physio

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Serotonin (5-hydroxytryptamine) contents of maternal blood, fetal cord blood, and placenta from thirty-five patients with toxaemia of pregnancy and forty normal pregnant subjects were estimated. Placental monoamine oxidase activity from ten normal and ten toxaemic cases were also estimated. An increased content and uptake of serotonin by platelets in maternal blood from toxaemic patients were observed and there was a concomitant reduction in platelet count. Raised levels of serotonin and a decrease in monoamine oxidase levels were observed in placentas of the toxaemic group. The levels of serotonin in fetal cord blood were significantly higher than those in normal maternal blood. It is suggested that the fetus could be the source of increased serotonin in this syndrome, due to the decrease in monoamine oxidase activity in the toxaemic placenta. An abnormality in indole amine metabolism may contribute to the pathology associated with toxaemia of pregnancy.

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Section: Discussionmentioning

confidence: 99%

Serotonin in Toxaemia of Pregnancy

Gujrati¹,

Shanker²,

Parmar³

et al. 1985

Clin Exp Pharma Physio

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show abstract

“…Since previous investigations in this laboratory have shown that angiotensin and serotonin share similar mechanisms in producing a pressor effect on the vasculature of the perfused human placenta (4), and because cyproheptadine was shown to be a potent serotonin antagonist when tested in this preparation (13), this compound was evaluated as an angiotensin antagonist in this investigation. Only moderate angiotensin antagonism was recorded when cypropheptadine was tested in this study (mean pressure decreases of 3.32 mm.…”

Section: Discussionmentioning

confidence: 99%