Effect of Certain Drugs on Perfused Human Placenta III

Ciuchta, Henry P.; Gautieri, Ronald F.

doi:10.1002/jps.2600530216

Cited by 24 publications

(7 citation statements)

References 10 publications

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“…There has been no conclusive evidence for this hypothesis obtained as yet. A constrictor effect of ACh in placental vessels has been observed (Ciuchta & Gautieri 1964) as has dilatation (von Euler 1938). It is possible that the large intrinsic background output of ACh ex vivo swamps the effects of ACh supplied exogenously, and that this has complicated interpretation of such experiments.…”

Section: Introductionmentioning

confidence: 97%

Human Placental Acetylcholine Content and Release at Parturition

Brennecke

Chen

King

et al. 1988

Clin Exp Pharma Physio

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1. Measurements were made of human placental acetylcholine (ACh) content and release into maternal and fetal circulations from placenta obtained before, during and after labours of both spontaneous and induced onsets. ACh content was determined in ex vivo placental biopsies using a radio-enzymatic assay. ACh release was determined by bioassay of the effluent from placental lobules perfused with amniotic fluid-like Kreb's containing physostigmine (2.4 mumol/l). 2. ACh content of placentae obtained after labour (spontaneous onset of labour, normal vaginal delivery) and during labour (spontaneous onset of labour, Caesarean section delivery) was significantly less than before labour (no labour onset, Caesarean section delivery). 3. Mean ACh output into maternal vessels 1.5-4.0 h after commencement of perfusion of placentae obtained after labour (spontaneous onset of labour, normal vaginal delivery) was significantly less than from those obtained before labour (no labour onset, Caesarean section delivery). No differences were found in ACh output into fetal vessels of placentae obtained before, during or after labour. 4. These results suggest a role for placental ACh in the events of human labour. The decrease in ACh content and maternal vascular release in placenta obtained after labour is consistent with a depletion of placental ACh during labour which may indicate ACh release at this time. The lack of any significant change in fetal vascular release of ACh in placenta obtained before, during or after labour, raises the possibility of different roles for ACh released into fetal and maternal vasculature.

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Section: Introductionmentioning

confidence: 97%

Human Placental Acetylcholine Content and Release at Parturition

Brennecke

Chen

King

et al. 1988

Clin Exp Pharma Physio

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“…Both agents, in a dose of 10.0 mg., augmented the pressor response to angiotensin an average of 35. 6 and 24.3%, respectively. This was to be expected in view of the work of Vogin and Buckley ( 5 ) who augmented the pressor effect of angiotensin with similar compounds in the anesthetized dog.…”

Section: Discussionmentioning

confidence: 99%

Effect of Certain Drugs on Perfused Human Placenta IX: Mode of Action of Angiotensin

Ward¹,

Gautieri

1969

Journal of Pharmaceutical Sciences

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“…The procedures concerned with the manipulation and preparation of the placentas for perfusion were described in a previous paper (2). A schematic diagram of the apparatus is shown in Fig.…”

Section: Methodsmentioning

confidence: 99%

“…vasculature (1,2,7), it is possible that when such drugs are administered to pregnant women they may disturb the homeostatic conditions of the placenta and exert serious effects on the fetus. Consequently, it is imperative to determine the action of all drugs on placental vasculature.…”

Section: *Recipient Of a Lunsford Richardson Pharmacy Awardmentioning

confidence: 99%

“…Therefore, since it has been shown that 5-hydroxytryptamine (serotonin) (l), sympathomimetics, and histamine (2) constrict placental vessels directly and also that the placental barrier is permeable to substances below a molecular weight of 1000 (3), allowing their passage from maternal to fetal circulation, any condition which actually causes an increased level of these normal body chemicals could, via placental transfer, ultimately lead to teratogenic effects (4), decreased fetal oxygenation (1,2), and even fetal death (5,6).…”

mentioning

confidence: 99%

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