Effect of cetirizine, a histamine (H1) receptor antagonist, on bone modeling during orthodontic tooth movement in rats

Meh, Alja; Sprogar, Špela; Vaupotič, Tomaž; Cör, Andrej; Drevenšek, Gorazd; Marc, Janja; Drevenšek, Martina

doi:10.1016/j.ajodo.2009.11.013

Cited by 33 publications

(31 citation statements)

References 21 publications

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“…It was reported that promethazine (H 1 R antagonist)‐treated ovariectomized rats were accompanied by a significant reduction in bone resorption that was detected by small trabecular spaces and increase the alveolar bone volume density . Moreover, Lesclouse et al.…”

Section: Discussionmentioning

confidence: 99%

“…It was reported that promethazine (H 1 R antagonist)-treated ovariectomized rats were accompanied by a significant reduction in bone resorption that was detected by small trabecular spaces and increase the alveolar bone volume density (38,39). Moreover, Lesclouse et al observed that short-term treatment with H 2 R antagonism strongly reduces Table 1 Alveolar bone histomorphometric analyses in the mandibles of the control and experimental groups…”

Section: J Oral Pathol Medmentioning

confidence: 99%

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The ability ofH₁orH₂receptor antagonists or their combination in counteracting the glucocorticoid‐induced alveolar bone loss in rats

Ezzat

Abbass

2013

J Oral Pathology Medicine

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Section: Discussionmentioning

confidence: 99%

Section: J Oral Pathol Medmentioning

confidence: 99%

The ability ofH₁orH₂receptor antagonists or their combination in counteracting the glucocorticoid‐induced alveolar bone loss in rats

Ezzat

Abbass

2013

J Oral Pathology Medicine

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“…29 Treatment with cetirizine (a 2 nd generation H1-antihistamine) did not have any impact on BMD values or bone tissue properties in H(+)/K(+) ATPase β subunit knockout (KO) mice, which are genetically modified to have high histamine levels leading to secondary decreases in BMD. 11,31 Recently, Folwarczna et al 14 administered loratadine (a 2 nd generation H1-antihistamine) to ovariectomized and non-ovariectomized rats with bone metabolism disorders. Short-term loratadine administration significantly improved bone metabolism and biomechanical bone properties in the non-ovariectomized rats.…”

Section: Discussionmentioning

confidence: 99%

Long-term administration of fenspiride has no negative impact on bone mineral density and bone turnover in young growing rats

Matuszewska¹,

Nowak²,

Jędrzejuk³

et al. 2019

Adv Clin Exp Med

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et al. Long-term administration of fenspiride has no negative impact on bone mineral density and bone turnover in young growing rats. AbstractBackground. Fenspiride is an antagonist of H1-histamine receptors that is used to treat acute and chronic respiratory tract infections and otitis media in children and adolescents.Objectives. The aim of the study was to assess the influence of long-term administration of fenspiride on bone mineral density (BMD) and bone turnover in young growing rats.Material and methods. The experiment was carried out on 18 young (8-week-old) male Wistar rats receiving either fenspiride 15 mg/kg intragastrically (ig) (group F) or saline solution 4 mL/kg ig (group C) for 3 months. On days 1 and 93, blood samples were collected and serum levels of calcium, phosphorus and markers of bone turnover were measured. On days 2 and 92, BMD was measured with dual-energy X-ray absorptiometry (DXA) using small animal software. Results.We detected no influence of fenspiride on weight gain, total body BMD (0.212 ±0.010 g/cm 2 vs 0.204 ±0.024 g/cm 2 ), hind limb BMD (0.264 ±0.016 g/cm 2 vs 0.252 ±0.027 g/cm 2 ), or bone macroscopic parameters. There were no significant differences between group F and group C in serum levels of osteocalcin (group F: 0.42 ±0.09 ng/mL vs group C: 0.43 ±0.08 ng/mL), C-terminal telopeptide of type I collagen (F: 0.31 ±0.08 ng/mL vs C: 0.29 ±0.08 ng/mL), osteoprotegerin (F: 5.47 ±0.78 pg/mL vs C: 5.35 ±1.65 pg/mL), receptor activator of nuclear factor kappa B ligand (F: 0.65 ±0.85 pg/mL vs C: 0.56 ±0.86 pg/mL), parathormone (F: 237 ±182 pg/mL vs C: 289 ±200 pg/mL), total calcium (F: 6.38 ±1.50 mg/dL vs C: 6.83 ±1.71 mg/dL), or inorganic phosphorus (F: 5. 19 ±1.76 mg/dL vs C: 5.50 ±1.32 mg/dL). Conclusions.Long-term administration of fenspiride has no negative impact on BMD and bone metabolism in young growing rats.

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“…Antihistamines [28] Blocks H 1 receptors on osteoblasts, leading to alterations in matrix remodelling and differentiation of osteoclasts…”

Section: Decrease In Tooth Movementmentioning

confidence: 99%

Adverse drug reactions in the oral cavity

Sivaramakrishnan

Sridharan

2016

Drugs Ther Perspect

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Drugs prescribed for various systemic disorders have become a boon in increasing life span over the recent years, but are not without adverse effects. As regards to the oral cavity, the drug-related adverse effects include hard and soft tissue alterations, such as tooth or soft tissue discolouration, abnormal tooth movement, gingival overgrowth, oral ulceration, halitosis, abnormal salivary flow, etc. The use of alternative medications or temporarily avoiding the use of the drug might cause regression or stop the progression of the adverse effects. This narrative review aims to identify all the major hard and soft tissue manifestations produced by drugs in the oral cavity, the drugs causing them and their prevention and treatment.

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Effect of cetirizine, a histamine (H1) receptor antagonist, on bone modeling during orthodontic tooth movement in rats

Cited by 33 publications

References 21 publications

The ability ofH₁orH₂receptor antagonists or their combination in counteracting the glucocorticoid‐induced alveolar bone loss in rats

The ability ofH₁orH₂receptor antagonists or their combination in counteracting the glucocorticoid‐induced alveolar bone loss in rats

Long-term administration of fenspiride has no negative impact on bone mineral density and bone turnover in young growing rats

Adverse drug reactions in the oral cavity

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Effect of cetirizine, a histamine (H1) receptor antagonist, on bone modeling during orthodontic tooth movement in rats

Cited by 33 publications

References 21 publications

The ability ofH1orH2receptor antagonists or their combination in counteracting the glucocorticoid‐induced alveolar bone loss in rats

The ability ofH1orH2receptor antagonists or their combination in counteracting the glucocorticoid‐induced alveolar bone loss in rats

Long-term administration of fenspiride has no negative impact on bone mineral density and bone turnover in young growing rats

Adverse drug reactions in the oral cavity

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The ability ofH₁orH₂receptor antagonists or their combination in counteracting the glucocorticoid‐induced alveolar bone loss in rats

The ability ofH₁orH₂receptor antagonists or their combination in counteracting the glucocorticoid‐induced alveolar bone loss in rats