Effect of Chamomile Oil as a Percutaneous Absorption Enhancer

Abstract

The aim of this study was to investigate the ability of Chamomile oil as absorption enhancers for cutaneously administered Silver Sulfadiazine by comparing it with a penetration enhancer Dimethyl Sulfoxide. Silver sulfadiazine is used in burn infection. Gel was selected as the vehicle for Silver Rat’ skin samples were placed in a continuous flow diffusion cell, with Silver Sulfadiazine gel on top. Receptor fluid samples were analyzed using high-performance liquid chromatography. The quantity of gel remaining on the skin surface after completion of each test was weighed and the amount of drug in the skin was analyzed. Addition of chamomile oil or Dimethyl Sulfoxide to the gel increased the percutaneous absorption of the drug. 5 % Chamomile oil was found to be the most efficient absorption enhancer in this comparison