Effect of Changes in Arterial pH on the Action of Adrenalin in Acute Adrenalin-Fast Asthmatics

Pressure-controlled ventilation in children with severe status asthmaticus*

“…However, there are no controlled studies demonstrating benefits of permissive hypercapnia compared with normocapnia. Moreover, hypercapnia and the resultant respiratory acidosis may be associated with undesirable consequences such as decreased catecholamine responsiveness, blunting of the effects of bronchodilators (22,23), and increased intracranial pressure. We aimed at achieving normocapnia in our patients using the pressure control, respiratory rate, inspiratory time, and expiratory time required to deliver the necessary tidal volume and minute alveolar ventilation.…”

Metabolic Acidosis in Status Asthmaticus

“…Correction of acid pH with sodium bi carbonate [3] or Tham [20] infusion may be followed by decrease in bron chial obstruction. This effect has been attributed to decreased response to catecholamines when the pH is low [36].…”

2 Methodological Considerations in Psychoendocrine Research

“…Such an increased tissue sensitivity may be caused by hyperventilatory alkalosis (Nash and Heath, 1961;Baisset and Montastruc, 1960; The age of the subjects must be taken into ac- Campbell et al, 1958;Blumenthal et al, 1961). count in comparing the results of various in-This alkalosis may in turn be suspected to in-vestigators.…”

“…Some of these studies do not entail any discernible harm to the subject, while others involve pain and still others possible hazards to health and well-being. Here, a cost-benefit analysis must be made, balancing possible unpleasantness and risk against the knowledge gained, knowledge that may eventually benefit society and ultimately, perhaps, the subject himself (Blumgart, 1969).…”