2004
DOI: 10.1152/ajplung.00331.2003
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Effect of changes in pH on wall tension in isolated rat pulmonary artery: role of the RhoA/Rho-kinase pathway

Abstract: Hyvelin, Jean-Marc, Clare O'Connor, and Paul McLoughlin. Effect of changes in pH on wall tension in isolated rat pulmonary artery: role of the RhoA/Rho-kinase pathway. Am J Physiol Lung Cell Mol Physiol 287: L673-L684, 2004. First published February 6, 2004 10.1152/ajplung.00331.2003 are resistant to the vasodilator effects of extracellular acidosis in systemic vessels; the mechanism underlying this difference between systemic and pulmonary circulations has not been elucidated. We hypothesized that RhoA/Rho-k… Show more

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Cited by 34 publications
(35 citation statements)
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“…More experiments are needed to clarify the intracellular signaling pathways involved in the acid-induced PG synthesis in AoSMCs. It is well known that acidosis may cause vasodilation of systemic circulation, while pulmonary arteries are resistant to the vasodilator effect of extracellular acidosis (15). Both extracellular pH and intracellular pH seem to be responsible for acid-induced vasodilation of systemic circulation (15,39).…”
Section: Discussionmentioning
confidence: 99%
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“…More experiments are needed to clarify the intracellular signaling pathways involved in the acid-induced PG synthesis in AoSMCs. It is well known that acidosis may cause vasodilation of systemic circulation, while pulmonary arteries are resistant to the vasodilator effect of extracellular acidosis (15). Both extracellular pH and intracellular pH seem to be responsible for acid-induced vasodilation of systemic circulation (15,39).…”
Section: Discussionmentioning
confidence: 99%
“…Acidosis has been shown to induce a variety of responses at whole animal, tissues, and cellular levels. In vascular systems, for example, acidosis causes vasodilation of systemic circulation at whole animal levels (14), relaxation in isolated vessels (15)(16)(17)(18)(19), and alteration of a variety of cellular activities at the cell levels, including cAMP accumulation (20) and changes in intracellular Ca 2ϩ concentration ([Ca 2ϩ ] i ) (21,22). Cyclic AMP accumulation and changes in [Ca 2ϩ ] i have been shown to regulate a variety of cellular responses.…”
mentioning
confidence: 99%
“…Acidification induces a variety of responses in the vascular system. Thus, acidification causes vasodilatation (16,17,19,49,56,58) and inhibition of proliferation and migration of vascular SMCs (15,39); however, the molecular mechanisms underlying these responses have not been fully elucidated (55). As for the lipid mediators (LPA and PGs), their roles in atherogenesis seem to be different.…”
mentioning
confidence: 99%
“…Moreover, cor pulmonale is an independent predictor of increased mortality, suggesting that pulmonary hypertension contributes directly to reduced survival (1,2). The increased pulmonary vascular resistance underlying chronic hypoxic pulmonary hypertension is accompanied by characteristic changes in the blood vessels, which include remodeling and thickening of the walls of precapillary vessels and sustained vasoconstriction (3)(4)(5)(6)(7)(8). These long-term structural and functional changes in the pulmonary vessels in response to hypoxia are unique to this circulation, and are not observed in the vasculature of other organs of the body.…”
mentioning
confidence: 99%